Feasibility of Assessing Prognostic Nutrition Index in Patients With Rectal Cancer Who Receive Preoperative Chemoradiotherapy

Okugawa, Yoshinaga; Toiyama, Yuji; Oki, Satoshi; Ide, Shozo; Yamamoto, Akira; Ichikawa, Takashi; Kitajima, Takahito; Fujikawa, Hiroyuki; Yasuda, Hiromi; Saigusa, Susumu; Hiro, Junichiro; Yoshiyama, Shigeyuki; Kobayashi, Minàko; Araki, Toshimitsu; Kusunoki, Masato

doi:10.1002/jpen.1041

Cited by 36 publications

(21 citation statements)

References 37 publications

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“…Low PNI has been found to be associated with a poor prognosis of some solid cancers. [7][8][9][10][11][12] However, the role of PNI in initially diagnosed NSCLC patients with bone metastasis remains unclear. Our retrospective study aims to evaluate the prognostic role of PNI in initially diagnosed NSCLC patients with bone metastasis.…”

Section: Introductionmentioning

confidence: 99%

High prognostic nutritional index (PNI) as a positive prognostic indicator for non‐small cell lung cancer patients with bone metastasis

Cao

Geng

et al. 2020

Clinical Respiratory J

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Introduction: Increasing evidence shows the close association between prognostic nutritional index (PNI) and overall survival (OS) of solid cancers including lung cancer. However, the role of PNI in non-small cell lung cancer patients (NSCLC) with bone metastasis remains unclear. Objective: To explore the prognostic role of PNI in NSCLC patients with bone metastasis. Methods: A retrospective analysis of 259 initially diagnosed NSCLC with bone metastasis was conducted. Univariate and multivariate analysis were used to assess the potential prognostic roles of parameters. Results: The most common symptoms initially presented were cough and chest pain. Two hundred patients (77.2%) received the treatment of bisphosphonates. Patients with low PNI were found in 154 (59.5%) patients. Median survival time for all cases was 286 days. The median OS for patients with low and high PNI was 227 and 389 days, respectively. The 6-month, 1-year and 2-year survival rates for patients with low PNI were 66.2%, 29.9% and 10.4% compared to 79.0%, 52.4% and 26.7% in patients with high PNI level. On univariate analysis, female patients, non-smokers, high PNI and systematic chemotherapy (P < 0.05) were shown to be closely correlated with a better prognosis of NSCLC patients with bone metastasis. Only PNI (P = 0.002), systematic chemotherapy (P = 0.026) and distant metastasis number (P = 0.044) held statistical significance on multivariate analysis. Conclusions: PNI represents a non-invasive, efficiency and convenient biomarker of NSCLC patients with bone metastasis. High PNI, systematic chemotherapy and distant metastasis number <2 are independent positive prognostic factors of NSCLC patients with bone metastasis.

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Section: Introductionmentioning

confidence: 99%

High prognostic nutritional index (PNI) as a positive prognostic indicator for non‐small cell lung cancer patients with bone metastasis

Cao

Geng

et al. 2020

Clinical Respiratory J

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“…Therefore, the identi cation of a novel biomarker that could predict prognosis and tumor response is vital. Recently, studies have shown that CEA [7], FARI [20], and PNI [21] are practical predictors of survival and tumor response in LARC patients who underwent radical surgery after NCRT. Hence, we veri ed the prognostic role of these parameters and established a CFP scoring system.…”

Section: Discussionmentioning

confidence: 99%

“…The prognostic nutritional index (PNI), based on the albumin level and lymphocyte count, is another widely used biomarker that combines in ammatory and nutritional parameters. Okugawa et al [21] analyzed rectal cancer patients who underwent NCRT and demonstrated that PNI could predict survival and tumor response.…”

Section: Introductionmentioning

confidence: 99%

“…Since CEA [7], FARI [20] and PNI [21] have all been found to serve as indicators of the prognosis and tumor response of LARC patients, we wanted to explore whether a combination of tumor, in ammation, and nutrition markers could more accurately predict patient prognosis and response. Hence, this study aimed to investigate the role of a novel CFP scoring system (a combination of CEA, FARI, and PNI) on the prognosis and chemoradiotherapy response of LARC patients undergoing radical surgery following NCRT.…”

Section: Introductionmentioning

confidence: 99%

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The Novel CFP Scoring System is a Reliable Marker in Predicting Response and Prognosis in Patients with Locally Advanced Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy

Liu

Wang

et al. 2020

Preprint

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Background: Preoperative tumor markers, inflammation, and nutritional status are considered important predictors of prognosis and tumor response in locally advanced rectal cancer (LARC) patients. This study aims to explore the prognostic value of carcinoembryonic antigen (CEA), the Fibrinogen-Albumin Ratio Index (FARI), the Prognostic Nutritional Index (PNI) and a combined scoring system in LARC patients.Methods: A total of 138 LARC patients undergoing radical surgery following neoadjuvant chemoradiotherapy (NCRT) between January 2012 and March 2019 were enrolled. The X-tile program was used to determine the optimal cutoff values of CEA, FARI, and PNI. A novel combined scoring system, CEA-FARI-PNI (CFP), was constructed. The prognostic ability of these factors was assessed by the time-dependent receiver operating characteristic (ROC) curve, Kaplan-Meier, Cox regression, and logistic regression. A nomogram was established to evaluate the predictive role of CFP in tumor response.Results: The optimal cutoff values of CEA, FARI, and PNI were 5.15 ng/l, 10.56%, and 42.25 g/L, respectively. The time-dependent ROC curve showed that compared to CEA, FARI, and PNI, CFP showed stable predictive efficacy for overall survival (OS) and disease-free survival (DFS). In multivariate analysis, CFP was the only factor that could independently predict OS (HR=8.117, p=0.001) and DFS (HR=4.994, p<0.001). Moreover, high CFP (OR=3.693, p=0.002) was also an independent risk factor of poor response. The area under the ROC curve (AUC) of the nomogram for predicting TRG (tumor regression grade) was better with CFP (0.717) than without (0.656) (p<0.05).Conclusions: The CFP score is an independent prognostic factor of OS, DFS, and tumor response in LARC patients. It might be a more reliable marker for predicting the prognosis of LARC patients.

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“…Our research group has previously demonstrated that various preoperative biomarkers reflecting host nutrition status, such as prognostic nutrition index (PNI), lymphocyte-C-reactive protein ratio, albumin-globulin ratio and psoas muscle index (PMI), could be used as predictive indicators for postoperative recurrence, especially in malignancies [11][12][13][14][15][16][17][18]. In addition, the advanced lung cancer inflammation index (ALI) is a newly proposed nutrition marker, and is defined by the combination of body mass index (BMI) and the level of preoperative serum albumin (Alb) and neutrophil-tolymphocyte ratio (NLR) [19,20].…”

Section: Introductionmentioning

confidence: 99%

The advanced lung cancer inflammation index predicts outcomes in patients with Crohn’s disease after surgical resection

et al. 2020

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Aim Precise biomarkers for predicting prognosis could help to identify high‐risk Crohn's disease (CD) patients to facilitate better follow‐up during the postoperative course. In this study, the primary aim is the identification of the most reliable nutrition marker that predicts surgical relapse in CD patients. Method We first evaluated the predictive value of various nutrition markers for postoperative surgical relapse in CD patients and identified the advanced lung cancer inflammation index (ALI) as a promising biomarker. Then, we assessed the clinical significance of preoperative ALI in CD patients using two cohorts. Results Preoperative ALI showed the highest correlation with reoperation rate compared with other nutritional parameters in CD patients receiving surgical resection (sensitivity 53%, specificity 86%, area under the curve 0.71). Lower levels of preoperative ALI were significantly correlated with the presence of perianal disease. A lower level of preoperative ALI was an independent prognostic factor for reoperation rate after an intestinal resection (hazard ratio 3.37, 95% CI 1.38–10.12, P = 0.006), and the prognostic impact of preoperative ALI was successfully validated in an independent cohort using the same cut‐off value. Conclusion Preoperative ALI might be useful for postoperative management of CD patients.

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Feasibility of Assessing Prognostic Nutrition Index in Patients With Rectal Cancer Who Receive Preoperative Chemoradiotherapy

Abstract: Pretreatment PNI could be useful in evaluating and managing patients with rectal cancer who undergo CRT followed by curative resection.

Cited by 36 publications

References 37 publications

High prognostic nutritional index (PNI) as a positive prognostic indicator for non‐small cell lung cancer patients with bone metastasis

High prognostic nutritional index (PNI) as a positive prognostic indicator for non‐small cell lung cancer patients with bone metastasis

The Novel CFP Scoring System is a Reliable Marker in Predicting Response and Prognosis in Patients with Locally Advanced Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy

The advanced lung cancer inflammation index predicts outcomes in patients with Crohn’s disease after surgical resection

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