Feasibility of Breast Cancer Screening by PIXE Analysis of Hair

Gholizadeh, Narges; Kabiri, Zeynab; Kakuee, O.; Salehkotahi, Mohsen; Changizi, Vahid; Fathollahi, V.; Oliaiy, P.; Omranipour, Ramesh

doi:10.1007/s12011-013-9671-2

Cited by 11 publications

(11 citation statements)

References 17 publications

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“…In this study, the average age of 43 women was 51.3 ± 11.5, which is less than screening populations (16) . Since in mammography there is radiation hazards to patients, and the sensitivity of …”

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confidence: 60%

“…In addition, comparing the results of pathology as gold standard and mammography in detecting mammography is decreases with increase of age (16) , the goal of this study was to determine if differences between XRD curve of healthy women and breast cancer patients can lead to early detection of breast cancer or prediction of disease without radiation hazards or not.…”

Section: Discussionmentioning

confidence: 99%

“…In order to cleaning of samples from any kind of external contamination, coded samples were taking washing method with ethanol and distilled water for three times and then dried in oven about 30 minutes at 80 o C temperature. Then, the samples were cut with surgical stainless steel scissors into *ine pieces about 2 mm and using a mortar the samples became powdered and drying in oven for about 10 hours at an 80 o C temperature (16) .…”

Section: Methodsmentioning

confidence: 99%

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Detection of breast cancer using non-invasive X-ray diffraction technique of hair: A preliminary study

Maziar¹,

Shahbazi‐Gahrouei²,

Tavakoli³

et al. 2016

IJRR

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Background: An early diagnosis of breast cancer relates directly to an accurate treatment plan and strategy. Early detec on of breast cancer before its development would be a significant reduc on of morbidity and mortality rates. The aim of this preliminary study is to inves gate the sensi vity of Wide Angle X-ray diffrac on (WAXRD) method on women hair samples of healthy and breast cancer pa ents in comparison with other modali es such as synchrotron based XRD beam and mammography. Materials and Methods: Hair samples were taken from occipital region of skull from healthy and breast cancer pa ents (43 women) were analyzed using X-ray diffrac on and the results were analyzed and compared with mammography and pathology reports. Results: The results of analyzed samples showed the sensi vity for purposed WAXRD method was 86% in comparison with synchrotron based XRD beam (64%) and also with mammography (70%). Conclusion: This non-invasive method is less harmful and is more sensi ve than the two other methods and help the physicians for choosing accurate treatment plan.

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confidence: 60%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Detection of breast cancer using non-invasive X-ray diffraction technique of hair: A preliminary study

Maziar¹,

Shahbazi‐Gahrouei²,

Tavakoli³

et al. 2016

IJRR

Self Cite

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“…A personal trace element profile for each patient that would include trace element measurements from tumor biopsies and serum may turn out helpful. For example, zinc/copper ratios and the estimation of trace element concentrations in hair samples may be of value 239 . Such trace element profiles and mutational analyses might also have prognostic value and guide treatment decisions for or against certain cancer therapies.…”

Section: Outlook and Possible Implications For Cancer Prevention Diamentioning

confidence: 99%

The disruption of trace element homeostasis due to aneuploidy as a unifying theme in the etiology of cancer

Engelken

Altmeyer

2014

Preprint

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Abstracts Abstract for ScientistsWhile decades of cancer research have firmly established multiple "hallmarks of cancer" 1,2 , cancer's genomic landscape remains to be fully understood. Particularly, the phenomenon of aneuploidy -gains and losses of large genomic regions, i.e. whole chromosomes or chromosome arms -and why most cancer cells are aneuploid remains enigmatic 3 . Another frequent observation in many different types of cancer is the deregulation of the homeostasis of the trace elements copper, zinc and iron. Concentrations of copper are markedly increased in cancer tissue and the blood plasma of cancer patients, while zinc levels are typically decreased [4][5][6][7][8][9] . Here we discuss the hypothesis that the disruption of trace element homeostasis and the phenomenon of aneuploidy might be linked. Our tentative analysis of genomic data from diverse tumor types mainly from The Cancer Genome Atlas (TCGA) project suggests that gains and losses of metal transporter genes occur frequently and correlate well with transporter gene expression levels. Hereby they may confer a cancer-driving selective growth advantage at early and possibly also later stages during cancer development. This idea is consistent with recent observations in yeast, which suggest that through chromosomal gains and losses cells can adapt quickly to new carbon sources 10 , nutrient starvation 11 as well as to copper toxicity 12 . In human cancer development, candidate driving events may include, among others, the gains of zinc transporter genes SLC39A1 and SLC39A4 on chromosome arms 1q and 8q, respectively, and the losses of zinc transporter genes SLC30A5, SLC39A14 and SLC39A6 on 5q, 8p and 18q. The recurrent gain of 3q might be associated with the iron transporter gene TFRC and the loss of 13q with the copper transporter gene ATP7B. By altering cellular trace element homeostasis such events might contribute to the initiation of the malignant transformation. Intriguingly, attenuation or overexpression of several of these metal transporter genes has been shown to lead to malignant cellular behavior in vitro. Consistently, it has been shown that zinc affects a number of the observed "hallmarks of cancer" characteristics including DNA repair, inflammation and apoptosis, e.g. through its effects on NF-kappa B signaling. We term this model the "aneuploidy metal transporter cancer" (AMTC) hypothesis and find it compatible with the cancer-promoting role of point mutations and focal copy number alterations in established tumor suppressor genes and oncogenes (e.g. MYC, MYCN, TP53, PIK3CA, BRCA1, ERBB2). We suggest a number of approaches for how this hypothesis could be tested experimentally and briefly touch on possible implications for cancer etiology, metastasis, drug resistance and therapy.. CC-BY-NC 4.0 International license not peer-reviewed) is the author/funder. It is made available under a The copyright holder for this preprint (which was . http://dx.doi.org/10.1101/002105 doi: bioRxiv preprint first posted online Jan. 29, 2014; [3...

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“…Other authors showed also that alterations in trace elements in plasma and cancer tissues were observed in patients with, for example, colorectal cancer [ 11 , 12 ], malignant breast tissues [ 13 ], malignant prostate [ 14 ], cancerous endometrial and ovarian tissues [ 14 ], and head and neck cancers [ 15 ]. Also, several studies have focused on the relationship between scalp hair trace element levels and cancer in patients from various geographical locations, that is, Turkey (Anatolia) [ 16 ], India (Malwa region, Punjab) [ 17 ], Pakistan (Rawalpindi district; Jamshoro) [ 6 , 18 – 21 ], Iran (Tehran) [ 22 ], Italy (Modena region) [ 23 ], and China (Guangdong Provence) [ 24 , 25 ] but not Poland. The role of trace elements in the development or inhibition of cancer remains to be fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Screening of Trace Elements in Hair of the Female Population with Different Types of Cancers in Wielkopolska Region of Poland

Czerny

Krupka

Ożarowski

et al. 2014

The Scientific World Journal

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Background. Cancer constitutes a major health problem worldwide. Thus, search for reliable and practical markers of the disease process remains the key issue of the diagnostic process. Objectives. The study aims at linking the trace element status of an organism, assessed by hair analysis, with the occurrence of cancer diseases. Material and Methods. Hair samples were collected from 299 patients with cancer diseases confirmed by a histopathological test and from 100 controls. Cancer patients were divided into three groups, depending on cancer type: hormone-dependent cancer, cancer of the alimentary tract, and cancer with high glycolytic activity. Mineral element analysis of hair was performed using an atomic emission spectrophotometer with inductively coupled plasma (ICP-OES) and inductively coupled plasma mass spectrometry (ICP-MS). Results. Statistically significantly lower concentrations of selenium, zinc, copper, germanium and boron, iron, and magnesium were observed in the three groups of cancer patients. Disturbance in the axis glucose-insulin and changes in concentrations of heavy metals and toxic elements were also noted. Conclusions. It seems safe to conclude that our results confirmed usefulness of hair element analysis in screening tests for the assessment of the biomarker of various cancer diseases in a female population.

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Feasibility of Breast Cancer Screening by PIXE Analysis of Hair

Cited by 11 publications

References 17 publications

Detection of breast cancer using non-invasive X-ray diffraction technique of hair: A preliminary study

Detection of breast cancer using non-invasive X-ray diffraction technique of hair: A preliminary study

The disruption of trace element homeostasis due to aneuploidy as a unifying theme in the etiology of cancer

Screening of Trace Elements in Hair of the Female Population with Different Types of Cancers in Wielkopolska Region of Poland

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