2022
DOI: 10.3390/brainsci12070904
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Feasibility of Canine Adenovirus Type 2 (CAV2) Based Vector for the Locus Coeruleus Optogenetic Activation in Non-Transgenic Rats: Implications for Functional Studies

Abstract: The locus coeruleus norepinephrine (LC-NE) system modulates many visceral and cognitive functions, while LC-NE dysfunction leads to neurological and neurodegenerative conditions such as sleep disorders, depression, ADHD, or Alzheimer’s disease. Innovative viral-vector and gene-engineering technology combined with the availability of cell-specific promoters enabled regional targeting and selective control over phenotypically specific populations of neurons. We transduced the LC-NE neurons in adult male rats by … Show more

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Cited by 2 publications
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“…The precise pathogenesis of FAdV-induced diseases remains elusive, as different strains pathogenicity may vary within the same serotype. Furthermore, the immune system status of avian, along with concurrent infections by other immunosuppressive agents, can significantly impact the occurrence and progression of viral infection ( Kabanova et al, 2022 ; Abdel-Alim et al, 2023 ).…”
Section: Introductionmentioning
confidence: 99%
“…The precise pathogenesis of FAdV-induced diseases remains elusive, as different strains pathogenicity may vary within the same serotype. Furthermore, the immune system status of avian, along with concurrent infections by other immunosuppressive agents, can significantly impact the occurrence and progression of viral infection ( Kabanova et al, 2022 ; Abdel-Alim et al, 2023 ).…”
Section: Introductionmentioning
confidence: 99%