Feasibility of Clinoptilolite Application as a Microporous Carrier for Ph-Controlled Oral Delivery of Metronidazole

Tondar, Mahdi; Nooshin, Bahram Jambar; Shetab-Boushehri, Seyed Farid; Shetab-Boushehri, Seyed Vahid

doi:10.1615/specialtopicsrevporousmedia.v5.i4.70

Cited by 12 publications

(11 citation statements)

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“…The influence of pH on the desorption process of the vitamins was studied through QCM-D by desorbing B complex vitamins (B1, B2, B3, and B12) from the BNC surfaces using two different pH values (2 and 6.5) and a phosphate buffer at 100 mM concentration ( Figure 4 ) [ 33 , 34 ]. Those pH values were selected aiming to simulate the changes in pH experienced in the human digestive system.…”

Section: Resultsmentioning

confidence: 99%

Surface Interactions between Bacterial Nanocellulose and B-Complex Vitamins

et al. 2020

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The interactions between films of bacterial nanocellulose (BNC) and B complex vitamins were studied using a Quartz Crystal Microbalance with Dissipation monitoring (QCM-D). Thin films of BNC were generated in situ by QCM-D, followed by real-time measurements of the vitamin adsorption. The desorption of vitamins was induced by rinsing the system using phosphate buffers at a pH of 2 and 6.5, emulating gastric conditions. Changes in frequency (which are proportional to changes in adsorbed mass, ∆m) detected by QCM-D were used to determine the amounts of vitamin adsorbed and released from the BNC film. Additionally, changes in dissipation (∆D) were proven to be useful in identifying the effects of the pH in both pristine cellulose films and films with vitamin pre-adsorbed, following its changes during release. The effects of pH on the morphology of the vitamin-BNC surfaces were also monitored by changes in rugosity from images obtained by atomic force microscopy (AFM). Based on this data, we propose a model for the binding phenomena, with the contraction on the relaxation of the cellulose film depending on pH, resulting in an efficient vitamin delivery process.

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Section: Resultsmentioning

confidence: 99%

Surface Interactions between Bacterial Nanocellulose and B-Complex Vitamins

et al. 2020

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“… Literature review on the ( A ) encapsulation and ( B ) in vitro release efficiency of synthetic/natural bioactive substances-zeolite carrier systems [ 13 , 15 , 22 , 26 , 27 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 ]. …”

Section: Figurementioning

confidence: 99%

Clinoptilolite Microparticles as Carriers of Catechin-Rich Acacia catechu Extracts: Microencapsulation and In Vitro Release Study

Yaneva

Ivanova

Popov³

2021

Molecules

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The main goal of the present study was to investigate the microencapsulation, in vitro release capacity and efficiency of catechin-rich Acacia catechu extract by Clinosorbent-5 (CLS-5) microparticles by in-depth detailed analyses and mathematical modelling of the encapsulation and in vitro release kinetics behaviour of the polyphenol-mineral composite system. The bioflavanol encapsulation and release efficiency on/from the mineral matrix were assessed by sorption experiments and interpretative modelling of the experimental data. The surface and spectral characteristics of the natural bioactive substance and the inorganic microcarrier were determined by Fourier Transform Infrared Spectroscopy (FTIR) and Ultraviolet/Visible (UV/Vis) spectrophotometric analyses. The maximum extent of catechin microencapsulation in acidic medium was 32%. The in vitro release kinetics study in simulated enzyme-free gastric medium (pH = 1.2) approved 88% maximum release efficiency achieved after 24 h. The in vitro release profile displayed that the developed bioflavanol/clinoptilolite microcarrier system provided sustained catechin in vitro release behaviour without an initial burst effect. Thus, the results from the present study are essential for the design and development of innovative catechin-CLS-5 microcarrier systems for application in human and veterinary medicine.

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“…Zeolite, a microporous mineral, is utilized as an additive in the fodder of livestock and poultry, owing to its ability to improve the absorptivity and bioavailability of some minerals and vitamins (Katsoulos et al., 2009; Li, Li, et al., 2015). Zeolite has been used in industries and medical field for its cation exchange property (Tondar et al., 2014). Recently, zeolite has garnered increasing attention, especially in the field of human health, owing to its anticancer and antioxidative effects (Pavelic et al., 2001; Zarkovic et al., 2003), sustained drug‐release property (Vilaca et al., 2013), and ethanol‐absorption capacity (Federico et al., 2015).…”

Section: Introductionmentioning

confidence: 99%

Zeolite‐containing mixture alleviates microbial dysbiosis in dextran sodium sulfate‐induced colitis in mice

Lyu

Jia

Deng

et al. 2020

Food Science & Nutrition

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Inflammatory bowel disease (IBD) is a multifactorial immunomodulatory disorder. In relative nosogenesis, gut microbiota has been the focus of research on IBD. In our previous study, we demonstrated the ameliorating effect of zeolite‐containing mixture (Hydryeast®, HY) on dextran sodium sulfate (DSS)‐induced colitis, through transcriptomics and proteomics. In the present study, we performed further investigation from the perspective of metagenomics using the gut microbiota. C57BL6 mice were provided an AIN‐93G basal diet or a 0.8% HY‐containing diet, and sterilized tap water for 11 days. Thereafter, colitis was induced by providing 1.5% (w/v) DSS‐containing water for 9 days. DNA was extracted from the cecal contents and pooled into libraries in a single Illumina MiSeq run. The resulting sequences were analyzed using Quantitative Insights Into Microbial Ecology (QIIME) software. According to the alterations in the relative abundance of certain bacteria, and the related gene and protein expressions, HY supplementation could improve the gut microbiota composition, ameliorate the degree of inflammation, inhibit the colonic mucosal microbial growth, and, to some extent, promote energy metabolism in the colon compared with the DSS treatment. Thus, we believe that HY may be a candidate to prevent and treat IBD.

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Feasibility of Clinoptilolite Application as a Microporous Carrier for Ph-Controlled Oral Delivery of Metronidazole

Cited by 12 publications

References 0 publications

Surface Interactions between Bacterial Nanocellulose and B-Complex Vitamins

Surface Interactions between Bacterial Nanocellulose and B-Complex Vitamins

Clinoptilolite Microparticles as Carriers of Catechin-Rich Acacia catechu Extracts: Microencapsulation and In Vitro Release Study

Zeolite‐containing mixture alleviates microbial dysbiosis in dextran sodium sulfate‐induced colitis in mice

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