Objective: To quantify long term effects of cardiac resynchronisation therapy (CRT) by biventricular pacing in patients with heart failure (HF). Methods: Regional changes in left ventricular (LV) contraction patterns effected by CRT in 19 patients with HF (12 with ischaemia; mean (SD) age 66 (9) years) with bundle branch block were examined by colour Doppler tissue velocity imaging (c-TVI). Time differences during main systolic tissue velocity peak (SYS) were compared in the basal and mid LV interventricular septum and in the corresponding LV free wall segments. Results: From baseline to long term (9.8 (3.0) months) CRT, ejection fraction increased from 21.8 (5.4)% to 30.8 (7.6)%, LV end diastolic diameter decreased from 7.6 (0.9) cm to 7.1 (0.8) cm, and end systolic diameter decreased from 6.4 (1.2) cm to 6.0 (1.2) cm (p , 0.05). LV peak tissue velocities were unchanged during follow up. At baseline, SYS in LV free wall was typically delayed by an average of 29 ms in the basal LV site and by 18 ms in the mid LV site. The regional movements of the LV free wall and interventricular septum were separated by an average of only 14 ms and 24 ms (p , 0.05) at the basal site and by 221 ms and 216 ms at the mid LV site during short term and long term CRT, respectively. Conclusions: The improved haemodynamic functions observed during CRT may be explained by a significant resynchronisation of the regional LV movement pattern during long term follow up.T he introduction of cardiac resynchronisation therapy (CRT) by biventricular pacing in patients with severe treatment refractory heart failure (HF) and bundle branch block has resulted in improvements in clinical symptoms, left ventricular (LV) function, and oxygen uptake even during long term follow up.1 Evidence for resynchronisation of the LV has been obtained by various imaging techniques. A recent echocardiographic study showed a radial endocardial wall motion resynchronisation of the LV by short term CRT and a direct relation with invasive haemodynamic variables.2 Colour Doppler tissue velocity imaging (c-TVI) provides better temporal and spatial resolution than other non-invasive techniques such as gated blood pool scintigraphy, which also has been used to show acute resynchronisation by CRT. Recently, c-TVI has shown an immediate effect of CRT by reducing the extent of myocardium at the LV base that displays delayed longitudinal contraction (that is, contraction in diastole after closure of the aortic valve), as well as a reduction in the number of segments displaying delayed contraction during long term CRT.6 Even during short term CRT, LV resynchronisation has recently been shown by comparing c-TVI with the QRS complex.
7In our studies, we have been able to show and for the first time quantify significant resynchronisation of the LV by using c-TVI at baseline and during short term CRT in patients with severe HF. 8 The objective of the present study was to measure and quantify the potential effects of long term CRT on reverse LV remodelling produced by changes in ...