Feasibility of Different Capillaroscopic Measures for Identifying Nailfold Microvascular Alterations

Ingegnoli, Francesca; Gualtierotti, Roberta; Lubatti, C.; Zahalkova, Lenka; Meani, Laura; Boracchi, Patrizia; Zeni, S.; Fantini, F

doi:10.1016/j.semarthrit.2007.10.008

Cited by 70 publications

(63 citation statements)

References 17 publications

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“…Minor abnormalities are commonly found even in healthy individuals, consisting of tortuous, crossing, and enlarged capillaries. Major abnormalities that are rarely found in normal persons and considered pathological in nature are giant, bushy, meandering, and branching capillaries [14]. However, one major difference from the results of the present study compared to those of previous studies is that branching capillaries were significantly more common in the control group than the exposed group, and the minor nonpathological abnormality such as the crossing capillary was significantly more common in the exposed group than the control group.…”

Section: Discussioncontrasting

confidence: 98%

“…Two sections of the fourth finger on each hand were marked and spanned 5 mm. Then, immersion oil or liquid paraffin was applied onto the skin to maximize the transparency of the keratin layer of the epithelial cells [14]. All subjects underwent high-(×200) and low-power (×100) microscopic examinations, with the total examination time ranging from 15 to 30 minutes.…”

Section: Nailfold Capillary Microscopy and Stockholm Stagingmentioning

confidence: 99%

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Nailfold capillary microscopy for evaluating hand-arm vibration syndrome

Lee

Sung

Park

et al. 2014

Ann of Occup and Environ Med

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Objectives: We evaluated nailfold capillary abnormalities in patients with hand-arm vibration syndrome using nailfold capillary microscopy.Methods: Fifty workers who underwent a special health examination because of exposure to hand-arm vibration at Ulsan University Hospital in 2012 (exposed group) and a control group of 50 white-collar employees were evaluated through a questionnaire survey regarding their present tasks, types of tools used, vibration exposure duration, use of protective wear, and medical history. Then, an occupational physician performed a physical examination for any hand deformities, skin problems, or motor and sensory dysfunctions of the upper extremities. The nailfold capillary morphologies (tortuous, crossing, bushy, meandering, branching, hemorrhage, avascular area, enlarged, and giant), capillary dimensions (afferent, top, venous, total width, and length), and specific counts (crossing and branching) on both fourth fingers were determined by a rheumatologist. Thereafter, the exposed subjects were assessed according to the Stockholm workshop classification scale. In total, 8 and 6 subjects in the exposed and control groups, respectively, were excluded from the study because of poor capillary microscopic image quality. In addition, 24 subjects in the exposed group with Stockholm vascular stage 0 were excluded. Finally, capillary morphology, dimensions, and specific counting were compared between the exposed (n = 18) and control groups (n = 44).Results: The exposed group had significantly greater crossing capillaries and abnormal capillary numbers that included crossing capillaries (crossing, branching, bushy, and meandering) but smaller branching and abnormal capillary numbers that excluded crossing capillaries (branching, bushy, and meandering) than the control group did. No significant difference in capillary dimensions was observed between the two groups. Despite the adjustment for age, smoking status, and underlying diseases, the statistical significance was unchanged. In the specific counting of the type of capillaries, the exposed group had a significantly higher total crossing count but fewer total branching count than the control group did. However, no statistical significance resulted after adjustment for age, smoking status, and underlying diseases. Conclusions:In this study, the exposed group had significantly more crossing capillaries and a higher crossing count than the control group did.

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Section: Discussioncontrasting

confidence: 98%

Section: Nailfold Capillary Microscopy and Stockholm Stagingmentioning

confidence: 99%

Nailfold capillary microscopy for evaluating hand-arm vibration syndrome

Lee

Sung

Park

et al. 2014

Ann of Occup and Environ Med

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“…Various previous studies report reliability of high magnification nailfold capillaroscopy, highlighting the implied need for standardisation [12,13,[16][17][18][19][20][21][22][23][24]. Some included only two observers [12,16,17,20,21].…”

Section: Discussionmentioning

confidence: 99%

“…Some included only two observers [12,16,17,20,21]. A small number of these studies included assessment of reliability of capillary density and/or apical width.…”

Section: Discussionmentioning

confidence: 99%

Intra-and inter-observer reliability of nailfold videocapillaroscopy — A possible outcome measure for systemic sclerosis-related microangiopathy

Dinsdale

Moore

O’Leary

et al. 2017

Microvascular Research

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“…A widened capillary was defined as having a total loop width of 490 mm, but o150 mm. 32 A giant capillary was defined as having a total loop width of 4150 mm. 32 Capillary density (number of loops per millimetre) was calculated by computer from the manually marked loops in the distal row, where a capillary loop was considered to be a distal loop if the apex of the capillary made an angle of 4901 with the apex of its adjacent capillaries.…”

Section: Quantitative Assessmentmentioning

confidence: 99%

Nailfold capillary abnormalities in sclerodermatous chronic GVHD

Hofstee

Waal

Voskuyl

et al. 2013

Bone Marrow Transplant

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Chronic GVHD (cGVHD) complicating allo-SCT commonly presents as sclerotic skin changes resembling systemic sclerosis (SSc), suggesting a common pathophysiological pathway. Damage to capillaries is considered an early event in the pathogenesis of SSc, and is associated with characteristic nailfold capillary abnormalities. Whether such nailfold capillary abnormalities occur in sclerodermatous cGVHD is unknown. Nailfold videocapillaroscopy (NVC) was used to evaluate capillary morphology, density and loop dimensions in 14 patients with sclerodermatous cGVHD, 14 sex-and age-matched SSc patients, and 14 healthy controls. It was shown that none of the cGVHD patients and controls, whereas all SSc patients showed severe capillary abnormalities. cGVHD patients and controls showed no differences in capillary density (9.05 vs 9.16 loops/mm, respectively, P ¼ 0.84), and capillary loop dimensions (total loop width 44.36 vs 45.56 mm, respectively, P ¼ 0.84). Compared with cGVHD patients, SSc patients had a reduced capillary density (9.05 vs 5.25 loops/mm, respectively, Po0.001), and an increase in capillary loop dimensions (total loop width 44.36 vs 99.97 mm, respectively, P ¼ o0.001). In conclusion sclerodermatous cGVHD patients do not show the characteristic microvascular abnormalities seen in SSc, suggesting that capillary damage does not contribute to the pathophysiology of sclerodermatous cGVHD, and making NVC unsuitable for early identification.

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Feasibility of Different Capillaroscopic Measures for Identifying Nailfold Microvascular Alterations

Cited by 70 publications

References 17 publications

Nailfold capillary microscopy for evaluating hand-arm vibration syndrome

Nailfold capillary microscopy for evaluating hand-arm vibration syndrome

Intra-and inter-observer reliability of nailfold videocapillaroscopy — A possible outcome measure for systemic sclerosis-related microangiopathy

Nailfold capillary abnormalities in sclerodermatous chronic GVHD

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