2022
DOI: 10.1371/journal.pone.0276912
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Feasibility of flow-related enhancement brain perfusion MRI

Abstract: Purpose Brain perfusion imaging is of enormous importance for various neurological diseases. Fast gradient-echo sequences offering flow-related enhancement (FREE) could present a basis to generate perfusion-weighted maps. In this study, we obtained perfusion-weighted maps without contrast media by a previously described postprocessing algorithm from the field of functional lung MRI. At first, the perfusion signal was analyzed in fast low-angle shot (FLASH) and balanced steady-state free precession (bSSFP) sequ… Show more

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Cited by 2 publications
(1 citation statement)
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“…However, both techniques share signal variations due to the inflow of spins from the vasculature into the imaging plane using subtractions as their underlying mechanism for the generation of the perfusion-weighted maps. Furthermore, our results show a decent similarity indicating a weak degree of perfusion-weighting by flow-related enhancement which might be sensitive to pathologies 53 . The real value of pulse-wave amplitude maps in pathologies must be confirmed in further clinical studies.…”
Section: Discussionmentioning
confidence: 69%
“…However, both techniques share signal variations due to the inflow of spins from the vasculature into the imaging plane using subtractions as their underlying mechanism for the generation of the perfusion-weighted maps. Furthermore, our results show a decent similarity indicating a weak degree of perfusion-weighting by flow-related enhancement which might be sensitive to pathologies 53 . The real value of pulse-wave amplitude maps in pathologies must be confirmed in further clinical studies.…”
Section: Discussionmentioning
confidence: 69%