Feasibility of hand-assisted laparoscopic sentinel node biopsy in open endometrial cancer surgery

Paucity of data evaluating patient centred outcomes following sentinel lymph node dissection in endometrial cancer: A systematic review

“…Of the 21 studies, five studies were prospective observational ( Mereu et al, 2018 , Mereu et al, 2020 , Buda et al, 2016 , Hagen et al, 2016 , Geppert et al, 2018 ), one was using a historical control ( Liu et al, 2017 ), eleven were retrospective observational studies ( Accorsi et al, 2020 , Casarin et al, 2020 , Stewart et al, 2020 , Leitao et al, 2020 , Uccella et al, 2018 , Moukarzel et al, 2017 , St Clair et al, 2016 , Goebel et al, 2020 , Peiretti et al, 2019 , Buda et al, 2017 , Imboden et al, 2019 ), three were retrospective database reviews, ( Wright et al, 2017 , Polan et al, 2019 , Gomez-Hidalgo et al, 2018 ) and one used a decision analysis model ( Suidan et al, 2018 ). There were no prospective randomized trials.…”

“…Four studies compared SLND between different surgical techniques; between single site versus multiport ( Mereu et al, 2020 , Moukarzel et al, 2017 ), mini laparoscopy versus standard laparoscopy ( Uccella et al, 2018 ) and different tracers ( Buda et al, 2016 ). Five studies had no comparison groups ( Mereu et al, 2018 , Hagen et al, 2016 , St Clair et al, 2016 , Goebel et al, 2020 , Peiretti et al, 2019 ).…”

“…Four studies reported ASA scores. One study ( Peiretti et al, 2019 ) reported a median ASA score of 2, while another ( Casarin et al, 2020 ) reported ASA scores of ≥3 (n = 63). The remaining two studies reported median ASA scores of 2 (range 1–3).…”

“…These studies included a total of 5922 patients, with 1164 patients receiving SLND. Of the 13 studies, four were prospective ( Mereu et al, 2018 , Mereu et al, 2020 , Hagen et al, 2016 , Geppert et al, 2018 ), two included retrospective and prospective cohorts ( Liu et al, 2017 , Imboden et al, 2019 ) and seven were retrospective studies ( Accorsi et al, 2020 , Casarin et al, 2020 , Stewart et al, 2020 , Uccella et al, 2018 , Moukarzel et al, 2017 , Peiretti et al, 2019 , Polan et al, 2019 ). There was considerable heterogeneity within the group of publications with regards to inclusion and exclusion criteria for histopathology, stage, grade and surgical management, and some studies also included patients with complex atypical hyperplasia (n = 3).…”

“…Estimated blood loss was reported in eleven studies, with some reporting mean or median, and one study reporting the proportion of patients with less than 100 mL estimated blood loss ( Mereu et al, 2020 ). Estimated blood loss (mean or median) ranged from 20 mL ( Accorsi et al, 2020 ) to 160 mL ( Peiretti et al, 2019 ) in SLND groups. In studies comparing SLND with systematic LND (n = 6) ( Accorsi et al, 2020 , Imboden et al, 2019 , Geppert et al, 2018 , Liu et al, 2017 , Casarin et al, 2020 , Stewart et al, 2020 ), all but one ( Geppert et al, 2018 ) reported a lower mean/median blood loss with SLND compared to systematic LND, and four ( Accorsi et al, 2020 , Liu et al, 2017 , Casarin et al, 2020 , Imboden et al, 2019 ) demonstrated a statistically significant reduction.…”