Feasibility of human lung ventilation imaging using highly polarized naturally abundant xenon and optimized three‐dimensional steady‐state free precession

Stewart, Neil J.; Norquay, Graham; Griffiths, Paul D.; Wild, Jim M.

doi:10.1002/mrm.25732

Cited by 65 publications

(58 citation statements)

References 32 publications

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“…The superior sensitivity and detail of information provided by ventilation-MRI also offers the prospect that this measurement will allow an earlier or more detailed radiation-free appreciation of the response to novel therapies than even LCI 9. The advent of high-quality HP gas ventilation-MRI using the cheaper and readily available 129 Xe isotope means that the technology is now much more readily clinically deployed 10. The ventilation-MRI presented here are thus exemplars of what may become routine assessments in detecting early disease and treatment effects.…”

Section: Discussionmentioning

confidence: 99%

Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI

Marshall

Horsley

Taylor

et al. 2017

Thorax

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Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI ABSTRACT Hyperpolarised 3 He ventilation-MRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6-16 years) with clinically stable mild cystic fibrosis (CF) (FEV 1 > −1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ventilation-MRI was the most sensitive method of detecting abnormalities, present in 89% of patients with CF, compared with CT abnormalities in 68%, LCI 47% and conventional MRI 22%. Ventilation defects were present in the absence of CT abnormalities and in patients with normal physiology, including LCI. Ventilation-MRI is thus feasible in young children, highly sensitive and provides additional information about lung structure-function relationships.

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Section: Discussionmentioning

confidence: 99%

Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI

Marshall

Horsley

Taylor

et al. 2017

Thorax

Self Cite

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“…Enrichment of the 129 Xe isotope has enabled robust replication of the major types of contrast-weighting demonstrated for 3 He MRI [27, 28]. Moreover, improved polarization methods for 129 Xe [10, 279] may make imaging of natural abundance HP 129 Xe feasible [280], thereby significantly reducing cost. Lastly, a recently introduced open source 129 Xe polarizer system offers a means to improve the availability of polarizer technology via local manufacturing using 3D printing technology [279, 281].…”

Section: Future Workmentioning

confidence: 99%

Magnetic resonance imaging with hyperpolarized agents: methods and applications

et al. 2017

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In the past decade, hyperpolarized (HP) contrast agents have been under active development for MRI applications to address the twin challenges of functional and quantitative imaging. Both HP helium (3He) and xenon (129Xe) gases have reached the stage where they are under study in clinical research. HP 129Xe, in particular, is poised for larger scale clinical research to investigate asthma, chronic obstructive pulmonary disease, and fibrotic lung diseases. With advances in polarizer technology and unique capabilities for imaging of 129Xe gas exchange into lung tissue and blood, HP 129Xe MRI is attracting new attention. In parallel, HP 13C and 15N MRI methods have steadily advanced in a wide range of pre-clinical research applications for imaging metabolism in various cancers and cardiac disease. The HP [1-13C] pyruvate MRI technique, in particular, has undergone phase I trials in prostate cancer and is poised for investigational new drug trials at multiple institutions in cancer and cardiac applications. This review treats the methodology behind both HP gases and HP 13C and 15N liquid state agents. Gas and liquid phase HP agents share similar technologies for achieving non-equilibrium polarization outside the field of the MRI scanner, strategies for image data acquisition, and translational challenges in moving from pre-clinical to clinical research. To cover the wide array of methods and applications, this review is organized by numerical section into 1) a brief introduction, 2) the physical and biological properties of the most common polarized agents with a brief summary of applications and methods of polarization, 3) methods for image acquisition and reconstruction specific to improving data acquisition efficiency for HP MRI, 4) the main physical properties that enable unique measures of physiology or metabolic pathways, followed by a more detailed review of the literature describing the use of HP agents to study 5) metabolic pathways in cancer and cardiac disease and 6) lung function in both pre-clinical and clinical research studies, 7) some future directions and challenges, and 8) an overall summary.

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“…HP 3 He MRI readily depicts regional ventilation heterogeneity in patients with pulmonary obstructive diseases (23). More recently, 129 Xe gas has emerged as the most promising alternative to address dwindling supplies of 3 He (24–26). 129 Xe MRI appears to more readily detect ventilation defects than 3 He MRI (21, 27) and has been used to visualize elimination of ventilation defects after bronchodilator administration (28).…”

Section: Introductionmentioning

confidence: 99%

Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution

Driehuys

Que

et al. 2016

Academic Radiology

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Background-Ventilation heterogeneity is impossible to detect with spirometry. Alternatively, pulmonary ventilation can be imaged 3-dimensionally using inhaled 129 Xe MRI. To date such images have been quantified primarily based on ventilation defects. Here, we introduce a robust means to transform 129 Xe MRI scans such that the underlying ventilation distribution and its heterogeneity can be quantified.

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Feasibility of human lung ventilation imaging using highly polarized naturally abundant xenon and optimized three‐dimensional steady‐state free precession

Cited by 65 publications

References 32 publications

Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI

Detection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI

Magnetic resonance imaging with hyperpolarized agents: methods and applications

Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution

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