Feasibility of in vivo structural analysis of high-resolution magnetic resonance images of the proximal femur

Krug, Roland; Banerjee, Suchandrima; Han, E. T.; Newitt, David C.; Link, Thomas M.; Majumdar, S.

doi:10.1007/s00198-006-0194-y

Cited by 31 publications

(44 citation statements)

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“…Resolution of clinical CT and magnetic resonance imaging (MRI) has improved significantly in recent years, and the subchondral bone structure of OA patients can now be analyzed more finely and quantitatively. (11,12) Evaluating these bone changes with clinical CT and MRI might be useful for understanding pathophysiology, prognosis prediction, treatment selection, and therapy evaluation.…”

Section: Introductionmentioning

confidence: 99%

Relationship between microstructure and degree of mineralization in subchondral bone of osteoarthritis: A synchrotron radiation µCT study

Chiba

Nango²,

Kubota³

et al. 2012

Journal of Bone and Mineral Research

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We analyzed the microstructure and degree of mineralization of the subchondral trabecular bone in hip osteoarthritis (OA) using synchrotron radiation computed tomography (SRCT) to identify the relationship between bone structure and bone turnover. Subchondral bone samples were extracted from femoral heads of 10 terminal-staged hip OA patients. The SRCT scan was performed at 30 keV energy and 5.9 mm voxel size. Trabecular bone structure, bone cyst volume, and the degree of trabecular bone mineralization were measured, and correlations between bone structure and the degree of mineralization were analyzed. In addition, the trabecular bone was divided into the area immediately surrounding the bone cyst and the remaining area, and they were compared. The average cyst volume fraction in the whole region was 31.8%, and the bone volume fraction in the bone region was 55.6%. Cyst volume was the only structural parameter that had a significant correlation with the degree of mineralization. The degree of mineralization was diminished when the bone cyst was larger (r ¼ À0.81, p ¼ 0.004). The trabecular bone immediately surrounding the bone cyst had a lower degree of mineralization when compared with the remaining trabecular bone (p ¼ 0.008). In the bone sclerosis of OA subchondral bone, there are many large and small bone cysts, which are expected to play a significant part in the high bone turnover of OA. ß

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Section: Introductionmentioning

confidence: 99%

Relationship between microstructure and degree of mineralization in subchondral bone of osteoarthritis: A synchrotron radiation µCT study

Chiba

Nango²,

Kubota³

et al. 2012

Journal of Bone and Mineral Research

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“…Differences in diamagnetic susceptibility at the interfaces between BM and trabecular bone structure cause a reduction of marrow relaxation time T2*, and the extent of this decay depends on density and microarchitecture of the surrounding trabeculae (126) Today, high resolution MRI allows the depiction of trabecular bone density and structure in vitro and in vivo with a high spatial resolution (in-plane resolutions as high as 78 μm; slice thickness of approximately 300 μm) (8,102,128,129). If at the beginning, the study of trabecular microarchitecture and cortical bone was limited to peripheral sites (like the radius, tibia and calcaneus), the use of optimized pulse sequences, high magnetic field systems (3 Tesla) and phased array coils led to enhanced SNR, allowing the investigation of deep-seated skeletal sites, such as the proximal femur (130). The potential of MRI as a diagnostic modality for the assessment of trabecular bone without the use of ionizing radiation has to be considered, however some limitations must be taken into account.…”

Section: Mri In Osteoporosismentioning

confidence: 99%

Quantitative imaging techniques for the assessment of osteoporosis and sarcopenia

Guerri

Mercatelli

Gómez

et al. 2018

Quant. Imaging Med. Surg.

117

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Bone and muscle are two deeply interconnected organs and a strong relationship between them exists in their development and maintenance. The peak of both bone and muscle mass is achieved in early adulthood, followed by a progressive decline after the age of 40. The increase in life expectancy in developed countries resulted in an increase of degenerative diseases affecting the musculoskeletal system. Osteoporosis and sarcopenia represent a major cause of morbidity and mortality in the elderly population and are associated with a significant increase in healthcare costs. Several imaging techniques are currently available for the non-invasive investigation of bone and muscle mass and quality. Conventional radiology, dual energy X-ray absorptiometry (DXA), computed tomography (CT), magnetic resonance imaging (MRI) and ultrasound often play a complementary role in the study of osteoporosis and sarcopenia, depicting different aspects of the same pathology. This paper presents the different imaging modalities currently used for the investigation of bone and muscle mass and quality in osteoporosis and sarcopenia with special emphasis on the clinical applications and limitations of each technique and with the intent to provide interesting insights into recent advances in the field of conventional imaging, novel high-resolution techniques and fracture risk.

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“…Moreover, due to newly developed surface coils and suitable acquisition pulse sequences, in vivo high-resolution trabecular bone images at the proximal femur, with a spatial resolution of 234 μm × 234 μm × 1500 μm, have recently been achieved 38) . Besides the gradient echo sequences obtained using the spin-echo sequence (3D FLASH: fast large-angle spin-echo), 3D high-resolution microstructure images of the distal radius are obtained in vivo, which is sometimes called a "virtual bone biopsy" 39) .…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Recent progress in bone imaging for osteoporosis research

Ito

2011

J Bone Miner Metab

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Advances in bone imaging techniques have provided tools for analyzing bone structure at the macro-, micro-and nano-level.Quantitative assessment of macrostructure can be achieved using dual X-ray absorptiometry (DXA) and quantitative computed tomography Further progress in bone imaging technology is promising to bring new aspects of bone structure in relation to bone strength to light, and to establish a means for analyzing bone structural properties in the every day clinical setting.

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Feasibility of in vivo structural analysis of high-resolution magnetic resonance images of the proximal femur

Cited by 31 publications

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Relationship between microstructure and degree of mineralization in subchondral bone of osteoarthritis: A synchrotron radiation µCT study

Relationship between microstructure and degree of mineralization in subchondral bone of osteoarthritis: A synchrotron radiation µCT study

Quantitative imaging techniques for the assessment of osteoporosis and sarcopenia

Recent progress in bone imaging for osteoporosis research

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