Feasibility of Including Green Tea Products for an Analytically Verified Dietary Supplement Database

Saldanha, Leila; Dwyer, Johanna T.; Andrews, Kathleen; Betz, Joseph M.; Harnly, James M.; Pehrsson, Pamela R.; Rimmer, Catherine A.; Savarala, Sushma

doi:10.1111/1750-3841.12838

Cited by 14 publications

(13 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The value of this review is that it highlights the challenges researchers face in working with information on botanicals declared on DS labels and in clinical trials. As previous reviews on caffeine and green tea have demonstrated, this review again shows that the amounts of botanical or botanical constituent, form (or composition), and identity of ingredients in botanical DSs were difficult to ascertain even on labels that complied with the DS label regulations (23,24). These challenges make estimating intakes and exposures to herbs and botanicals difficult for epidemiological studies that use data solely from DS labels.…”

Section: Discussionmentioning

confidence: 68%

Culinary Spice Plants in Dietary Supplement Products and Tested in Clinical Trials

Saldanha

Dwyer

Betz

2016

Advances in Nutrition

View full text Add to dashboard Cite

Dried plant parts used as culinary spices (CSs) in food are permitted as dietary ingredients in dietary supplements (DSs) within certain constraints in the United States. We reviewed the amounts, forms, and nutritional support (structure/function) claims of DSs that contain CS plants listed in the Dietary Supplement Label Database (DSLD) and compared this label information with trial doses and health endpoints for CS plants that were the subject of clinical trials listed in clinicaltrials.gov. According to the DSLD, the CS plants occurring most frequently in DSs were cayenne, cinnamon, garlic, ginger, pepper, rosemary, and turmeric. Identifying the botanical species, categorizing the forms used, and determining the amounts from the information provided on DS labels was challenging. CS plants were typically added as a component of a blend, as the powered biomass, dried extracts, and isolated phytochemicals. The amounts added were declared on about 55% of the labels, rendering it difficult to determine the amount of the CS plant used in many DSs. Clinicaltrials.gov provided little information about the composition of test articles in the intervention studies. When plant names were listed on DS labels and in clinical trials, generally the common name and not the Latin binomial name was given. In order to arrive at exposure estimates and enable researchers to reproduce clinical trials, the Latin binomial name, form, and amount of the CS plant used in DSs and tested in clinical trials must be specified.

show abstract

Section: Discussionmentioning

confidence: 68%

Culinary Spice Plants in Dietary Supplement Products and Tested in Clinical Trials

Saldanha

Dwyer

Betz

2016

Advances in Nutrition

View full text Add to dashboard Cite

show abstract

“…Extracts that are used in bodybuilding and weight loss have also been linked to liver injury. This has led to studies of the composition of different supplements [ 50 , 51 ]. Causes of liver toxicity from supplements appear to be due to insufficient regulatory authority, inaccurate product labeling, adulterants and inconsistent sourcing of ingredients [ 52 ].…”

Section: Challenges: Scientific Perspectivesmentioning

confidence: 99%

Dietary Supplements: Regulatory Challenges and Research Resources

2018

Self Cite

View full text Add to dashboard Cite

Many of the scientific and regulatory challenges that exist in research on the safety, quality and efficacy of dietary supplements are common to all countries as the marketplace for them becomes increasingly global. This article summarizes some of the challenges in supplement science and provides a case study of research at the Office of Dietary Supplements at the National Institutes of Health, USA, along with some resources it has developed that are available to all scientists. It includes examples of some of the regulatory challenges faced and some resources for those who wish to learn more about them.

show abstract

“…Researchers often are interested in whether a single ingredient or multiple ingredients of dietary supplements are responsible for the biological effects observed. Such questions were important in assessing the ill effects of ephedra supplements, which were banned from the market in 2004, and more recently of caffeineand green tea-containing dietary supplements and energy drinks that appeared to be associated with cardiovascular abnormalities in some users (13,17,18). Additional codes were also created in DSLD for product categories/types commonly reported in NHANES such as single vitamin and single mineral (e.g., calcium and vitamin D) product, multivitamin and mineral with botanicals, and omega-3 supplements (15).…”

Section: Descriptionmentioning

confidence: 99%

Characteristics and Challenges of Dietary Supplement Databases Derived from Label Information

Saldanha

Dwyer

Bailen

et al. 2018

The Journal of Nutrition

View full text Add to dashboard Cite

Launched in 2008, the Dietary Supplement Label Database (DSLD) permits the search of any term that appears anywhere on product labels. Since then, the database's search and download features have been periodically improved to enhance use for researchers and consumers. In this review, we describe how to customize searches and identify products and ingredients of interest to users in the DSLD, and provide the limitations of working with information derived from dietary supplement product labels. This article describes how data derived from information printed on product labels are entered and organized in the DSLD. Among the challenges are determining the chemical forms, types of extract, and amounts of dietary ingredients, especially when these are components of proprietary blends. The FDA announced new dietary supplement labeling regulations in May 2016. The 2017 DSLD has been updated to reflect them. These new regulations and examples cited in this article refer to this redesigned version of the DSLD. Search selection characteristics such as for product type and intended user group are as described in FDA guidance and regulations for dietary supplements. For this reason, some age groups (such as teens and seniors) and marketing recommendations for use (e.g., weight loss, performance, and other disease- or condition-specific claims) are not included in the search selections. The DSLD user interface features will be revised periodically to reflect regulatory and technologic developments to enhance user experience. A comprehensive database derived from analytically verified data on composition would be preferable to label data, but is not feasible for technical, logistic, and financial reasons. Therefore, a database derived from information printed on product labels is the only practical option at present for researchers, clinicians, and consumers interested in the composition of these products.

show abstract

Feasibility of Including Green Tea Products for an Analytically Verified Dietary Supplement Database

Cited by 14 publications

References 17 publications

Culinary Spice Plants in Dietary Supplement Products and Tested in Clinical Trials

Culinary Spice Plants in Dietary Supplement Products and Tested in Clinical Trials

Dietary Supplements: Regulatory Challenges and Research Resources

Characteristics and Challenges of Dietary Supplement Databases Derived from Label Information

Contact Info

Product

Resources

About