Feasibility of interstitial diffuse optical tomography using cylindrical diffusing fibers for prostate PDT

Lü, Xing; Wang, Ken Kang Hsin; Zhu, Timothy C.

doi:10.1088/0031-9155/58/10/3461

Cited by 14 publications

(11 citation statements)

References 38 publications

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“…In this report, the absence of recorded PpIX fluorescence correlated with unfavorable clinical outcome. From the laser light transmission between fibers, one can calculate optical tissue parameters as demonstrated for iPDT of the prostate by Liang et al .…”

Section: ‐Ala Based Photodynamic Therapy Of Malignant Gliomamentioning

confidence: 99%

5‐ALA in the management of malignant glioma

Stepp¹,

2018

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Background: Patients suffering from malignant gliomas have a poor prognosis. For the surgical treatment of these tumors, 5-aminolevulinic acid (5-ALA) has become a new standard. Aims: This review intends to provide an overview over current status, significance, limitations, and future perspectives of 5-ALA based fluorescence guided surgery and photodynamic therapy for brain tumor patients. Materials and Methods: From peer reviewed publications on the many aspects connected with this topic, those with potential clinical relevance were selected and put in the context of our own experience. Results and Discussion: The high tumor selectivity of accumulation of fluorescent protoporphyrin IX (PpIX) after systemic administration of 5-ALA enables intra-operative fluorescence guidance, which is unimpaired by brainshift and does not require expensive equipment. The neurosurgical aim of complete resection of enhancing tumor can now more easily be achieved, which improves prognosis in these patients. Nevertheless, despite better surgery tumors will inevitably recur. In order to further prolong survival, the phototoxic properties of PpIX are presently being exploited in clinical trials of post-operative or interstitial photodynamic therapy (PDT). Conclusion: 5-ALA based fluorescence guidance and PDT offer an intriguing new option for the management of malignant gliomas. Lasers Surg. Med. 50:399-419, 2018.

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Section: ‐Ala Based Photodynamic Therapy Of Malignant Gliomamentioning

confidence: 99%

5‐ALA in the management of malignant glioma

Stepp¹,

2018

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“…The second algorithm (2), the so‐called continuous method , considers the whole fiber as a line light source with 2D cylindrical light emission characteristics . It computes the fluence rate values using the minimal distance d from the fiber.…”

Section: Methodsmentioning

confidence: 99%

“…However, implementing such a model in a Treatment Planning System (TPS) remains complicated since it requires many preliminary steps (optimized meshes, light source areas definition) to obtain significant results. Another model of light transport, known as the analytics methods, stems from the steady‐state solution of the wave propagation equation . The simplicity of implementation and short time computing make them particularly interesting for routine clinical applications and TPS implementation.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic therapy for glioblastoma: A preliminary approach for practical application of light propagation models

et al. 2017

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Abstract:Purpose Photodynamic therapy (PDT) is a promising treatment modality to be added in the management of glioblastoma multiforme (GBM). Light distribution modeling is required for planning and optimizing PDT. Several models have been developed to predict the light propagation inside biological tissues. In the present study, two analytical methods of light propagation emitted from a cylindrical fiber source were evaluated: a discrete and a continuous method. MethodsThe two analytical approaches were compared according to their fluence rate results. Several cylindrical diffuse lengths were evaluated, and the relative deviation in the fluence rates was estimated. Moreover, a sensitivity analysis was conducted to compute the variance of each analytical model. ResultsThe discrete method provided fluence rate estimations closer to the Monte-Carlo simulations than the continuous method. The sensitivity study results did not reveal significant differences between the variance of the two analytical models.Conclusions Although the discrete model provides relevant light distribution, the heterogeneity of GBM tissues was not considered. With the improvement in parallel computing that drastically decreased the computing time, replacing the analytical model by a Monte-Carlo GPU-accelerated code appeared relevant to the GBM case. Nonetheless, the analytical modeling may still function in the optimization algorithms, which might be used in the Photodynamic treatment planning system.

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“…One example of this is the use by Liang et al (2013) of existing cylindrical diffusing fibers (currently used for diffuse optical tomography) as a light source for PDT inside a phantom prostate. The study does mostly focus on the use of PDT for anticancer purposes, but the use of such techniques to deliver light to otherwise difficult to illuminate tissues is intriguing.…”

Section: Interstitial Fibersmentioning

confidence: 99%