Feasibility of Intracoronary β-Irradiation to Reduce Restenosis After Balloon Angioplasty

Abstract

This early experience demonstrates that our approach is feasible, and no side effects attributable to radiation were noted during a 6-month period of follow-up. Whether higher doses of beta-irradiation will favorably affect post-PTCA restenosis in patients must await further evaluation.

Hotline Editorials

“…The results to date are conflicting [14] . Verin et al [15] treated 15 patients undergoing coronary angioplasty with 90 Y, a beta emitter. The results were disappointing due to a loss index of 50% and restenosis rate of 40% at 6 months.…”

New Frontiers in Interventional Cardiology

“…Assuming the target for radiotherapy is the adventitial border, a noncentered source will deliver a higher radiation dose to the adventitia closest to the catheter and a lower radiation dose to the adventitia furthest from the catheter. Alternatively, catheter centering systems, using either a segmented balloon 9 or a helical balloon 10 that allows perfusion during inflation have been developed to reduce dose heterogeneity by maintaining the source in the center of the lumen.…”

Radiation therapy to prevent coronary artery restenosis

“…39 In this study 18 Gy was delivered to the luminal surface with a 29 mm 90 Y coil inserted into a closed end segmented balloon catheter following PTCA. Due to decay of the source (T1/2=64 hours) the treatment time was variable but averaged 6-7 minutes.…”