Feasibility of laparoscopic peritonectomy followed by intra-peritoneal chemohyperthermia: An experimental study

Ferron, Gwénaël; Gesson-Paute, Amélie; Classe, Jean‐Marc; Querleu, Denis

doi:10.1016/j.ygyno.2005.06.043

Cited by 36 publications

(26 citation statements)

References 15 publications

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“…In other pig model study by Ferron et al [2], a CRS (parietal and pelvic peritonectomy) plus HIPEC was performed by a laparoscopic approach, using a hand-assisted device. In our model, that of closed-abdomen laparoscopic HIPEC by CO 2 recirculation system, a turbulent flow is created into the abdominal cavity which is observed through the device placed in the middle of the abdominal cavity [4].…”

Section: Discussionmentioning

confidence: 99%

“…HIPEC management by laparoscopic approach after cytoreductive surgery (CRS) completed locoregional treatment of PM, and may be feasible and safe after appropriate patient selection. This treatment (CRS þ HIPEC laparoscopic) has been administered by other groups in animal models and patients [2,3], with no higher morbidity and mortality than other HIPEC approaches, in selected cases.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO₂ recirculation system and clinical translation in peritoneal carcinomatosis

Sánchez-García

Padilla

Campos

et al. 2017

International Journal of Hyperthermia

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Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO 2 recirculation system and clinical translation in peritoneal carcinomatosis Susana S anchez-Garc ıa, David Padilla-Valverde, Pedro Villarejo-Campos, Esther P. Garc ıa-Santos and Jes us Mart ın-Fern andez Department of General Surgery, University General Hospital, Medicine School, University of Castilla la Mancha, Ciudad Real, Spain ABSTRACT Introduction: Hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective treatment for peritoneal carcinomatosis (PC). Laparoscopic surgery is performed in the treatment of colorectal and appendiceal cancer, and PC from diverse origin in selected patients. HIPEC management by laparoscopic approach after cytoreductive surgery (CRS) completed locoregional treatment of PC, and may be feasible and safe after appropriate patient selection. Objective: Development of an experimental model of HIPEC by laparoscopic approach, with CO 2 recirculation. Clinical translation in two patients with PC and low peritoneal cancer index. Material and methods: We performed CRS in a porcine model of 5 pigs (35-38 kg) by laparoscopic approach. Laparoscopic HIPEC by CO 2 recirculation system was performed; laparoscopic access was used for catheter input and output placement (Paclitaxel 175 mg/m 2 for 60 min at 42 C). The experimental variables were: blood gases, haemodynamic and intra-abdominal and central temperature. Clinical model application was performed in three cases with PC from colorectal origin. Results: No statistically significant differences was found in blood gases, haemodynamic or temperature in the experimental study. In clinical study, there were no technical complications during laparoscopic-HIPEC approach, and we observed no changes in haemodynamic variables during the procedure. Conclusions: CRS and HIPEC laparoscopic model by CO 2 recirculation system is safe and feasible technique in selected patients, that include low PC index, local and accessible tumour recurrences or high-risk of PC tumours.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO₂ recirculation system and clinical translation in peritoneal carcinomatosis

Sánchez-García

Padilla

Campos

et al. 2017

International Journal of Hyperthermia

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“…In this context, a remarkable role was played by preoperative radiologic examination, and possibly IP laparoscopic evaluation, to better identify the appropriate subset of patients for this treatment regimen. Moreover, HIPEC can be safely administered in combination with minimally invasive surgical procedures, such as laparoscopic peritonectomy, both in animal models and patients with OC and platinum-sensitive recurrent disease [58,60]. Furthermore, it is plausible that a larger number of patients with recurrent disease will benefit in the future from minimally invasive techniques, greater accuracy in assessing disease extension, wider diffusion of robotic/laparoscopic approaches, and increased surgeon expertise.…”

Section: Futurementioning

confidence: 99%

New Trials

Costantini¹,

Fagotti²,

Montori³

et al. 2015

Treatment of Peritoneal Surface Malignancies

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“…Adhesiolysis, tumor resection, and chemotherapy distribution may be facilitated by use of a hand-assist port [45,46].…”

Section: Introductionmentioning

confidence: 99%

The Role of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer

Helm

2009

The Oncologist

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Overall outcomes for women with epithelial ovarian cancer (EOC) remain relatively poor, and superior methods of treatment are needed. EOC is a peritoneal surface malignancy that is relatively sensitive to chemotherapy agents, making it a good target for i.p. chemotherapy. Because there is strong laboratory data demonstrating the ability of hyperthermia to increase the efficacy of chemotherapeutic agents, the addition of hyperthermia to i.p. chemotherapy, hyperthermic intraperitoneal chemotherapy (HIPEC), makes theoretical sense. This article reviews the current literature and discusses the possible role for HIPEC in EOC at significant natural history time points: front line, at the time of interval debulking, in consolidation, and for recurrent disease. The conclusion is that much further research is needed but that HIPEC could sensibly be researched at all the natural history time points in EOC. The Oncologist 2009;14:683-694

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Feasibility of laparoscopic peritonectomy followed by intra-peritoneal chemohyperthermia: An experimental study

Cited by 36 publications

References 15 publications

Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO₂ recirculation system and clinical translation in peritoneal carcinomatosis

Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO₂ recirculation system and clinical translation in peritoneal carcinomatosis

New Trials

The Role of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer

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Feasibility of laparoscopic peritonectomy followed by intra-peritoneal chemohyperthermia: An experimental study

Cited by 36 publications

References 15 publications

Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO2 recirculation system and clinical translation in peritoneal carcinomatosis

Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO2 recirculation system and clinical translation in peritoneal carcinomatosis

New Trials

The Role of Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Ovarian Cancer

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Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO₂ recirculation system and clinical translation in peritoneal carcinomatosis

Hyperthermic chemotherapy intra-abdominal laparoscopic approach: development of a laparoscopic model using CO₂ recirculation system and clinical translation in peritoneal carcinomatosis