2018
DOI: 10.1016/j.phro.2018.09.002
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Feasibility of magnetic resonance imaging-only rectum radiotherapy with a commercial synthetic computed tomography generation solution

Abstract: A B S T R A C TBackground and purpose: Synthetic computed tomography (sCT) images enable magnetic resonance (MR)-based dose calculations. This work investigated whether a commercially available sCT generation solution was suitable for accurate dose calculations and position verification on patients with rectal cancer. Material and methods: For twenty rectal cancer patients computed tomography (CT) images were rigidly registered to sCT images. Clinical volumetric modulated arc therapy plans were recalculated on… Show more

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Cited by 24 publications
(34 citation statements)
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“…Wang et al [21] obtained median gamma-index pass-rate of 99.9% (99.4–100.0%) and medians of the dose difference averages were 0.21 Gy (0.2–0.3 Gy). In addition, Maspero et al [20] evaluated the feasibility of the same method used in this study (sCTb) for rectal cancer patients obtaining the mean gamma-index pass-rate of 95.2 (4.0)% and mean dose deviation of −0.3 (0.2)% of prescription dose. Liu et al [22] evaluated the sCT method for gynecological cancer patients obtaining the PTV dose deviation of 0.2 (0.4) Gy for D 0.5cc and 0.3 (0.3) Gy for D 99% .…”
Section: Discussionmentioning
confidence: 99%
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“…Wang et al [21] obtained median gamma-index pass-rate of 99.9% (99.4–100.0%) and medians of the dose difference averages were 0.21 Gy (0.2–0.3 Gy). In addition, Maspero et al [20] evaluated the feasibility of the same method used in this study (sCTb) for rectal cancer patients obtaining the mean gamma-index pass-rate of 95.2 (4.0)% and mean dose deviation of −0.3 (0.2)% of prescription dose. Liu et al [22] evaluated the sCT method for gynecological cancer patients obtaining the PTV dose deviation of 0.2 (0.4) Gy for D 0.5cc and 0.3 (0.3) Gy for D 99% .…”
Section: Discussionmentioning
confidence: 99%
“…The filling was equivalent to density override by water in the treatment planning system (TPS) corresponding to a clinical practice used with patients encompassing large air volumes at our institution. The same approach was used [20] or suggested to be used [29] in the dosimetric evaluations of MRI-only methods in order to avoid confounding dosimetric differences not related to the sCT methods.…”
Section: Methodsmentioning
confidence: 99%
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“…Dixon images were generated as part of a proprietary solution (MRCAT, rev. 257, Philips Healthcare, Finland) that enabled MR-based dose calculation for patients with prostate cancer [36,37]. The imaging parameters, reported in Table 1, were locked by the vendor; therefore, they were stable through the whole study.…”
Section: Patient Data Collectionmentioning
confidence: 99%
“…MRI offers higher soft tissue contrast for tumor and organ definition but lacks information about electron density, which is a prerequisite for accurate dose calculation. To overcome this, several groups have proposed strategies to generate synthetic CT data sets derived solely from MRI data [53] , [54] , [55] , [56] . First dosimetric analysis of such MR-only workflow showed quite promising results for tumors in the pelvic region [57] .…”
Section: Mri-guided Rtmentioning
confidence: 99%