Feasibility of Online Neuromodulation Using Transcranial Alternating Current Stimulation in Schizophrenia

Sreeraj, Vanteemar S.; Shanbhag, Vandita; Nawani, Hema; Shivakumar, Venkataram; Dinakaran, Damodharan; Bose, Anushree; Narayanaswamy, Janardhanan C.; Venkatasubramanian, Ganesan

doi:10.4103/0253-7176.198937

Cited by 24 publications

(39 citation statements)

References 13 publications

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“…Finally, multicentre double-blind clinic trials could be fostered to investigate larger sample sizes. This may also facilitate the utility of different stimulation protocols in different patients or within the same individuals to rule out a stimulation effect per se [4,125,131,150] and to question the potential synergism of different stimulation parameters, respectively (for more technical guidance: [12,[205][206][207]).…”

Section: Discussionmentioning

confidence: 99%

“…First, in schizophrenia, frontal alpha tACS was promising as an add-on treatment for persistent delusions [ 128 ] and was capable of normalizing disturbed alpha oscillations correlated with a decrease in auditory hallucinations [ 4 , 131 ]. On the other hand, frontal gamma tACS has not shown effects so far [ 125 , 129 ]. Case reports revealed that frontal theta tACS could be helpful for improving clinical symptoms, even in schizophrenia with clozapine resistance [ 125 – 127 ].…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, frontal gamma tACS has not shown effects so far [ 125 , 129 ]. Case reports revealed that frontal theta tACS could be helpful for improving clinical symptoms, even in schizophrenia with clozapine resistance [ 125 – 127 ]. Second, in depression, bifrontal alpha tACS was able to normalize alpha oscillations and concurrently showed a higher response rate for at least two weeks [ 150 ].…”

Section: Discussionmentioning

confidence: 99%

“…Finally, frontal gamma tACS might support a potential role for tACS as a diagnostic or prognostic tool in MCI and AD [ 194 ]. All the studies reported neither serious side effects nor exacerbation of clinical symptoms (i.e., manic shift or worsening of the clinical phenotype) [ 3 , 4 , 125 – 129 , 131 , 150 – 152 , 185 ].…”

Section: Discussionmentioning

confidence: 99%

“…They were based on previous findings of reduced theta and gamma oscillation in relation to working memory, especially on the frontal region. One of them showed that one session of 20 min tACS applied to the left DLPFC (F3) and the left posterior parietal region (P3) in theta frequency (6 Hz), but not gamma (40 Hz), was able to improve performance in WM task [ 125 ]. The same tACS protocol was replicated in the other case report but for five consecutive days, resulting in improved working memory after 6 Hz-tACS, as well as an improvement in other cognitive domains.…”

Section: Altered Brain Oscillations and Tacs Applications In Psychiatmentioning

confidence: 99%

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Transcranial alternating current stimulation (tACS): from basic mechanisms towards first applications in psychiatry

Elyamany

Leicht

Herrmann

et al. 2020

Eur Arch Psychiatry Clin Neurosci

163

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Transcranial alternating current stimulation (tACS) is a unique form of non-invasive brain stimulation. Sinusoidal alternating electric currents are delivered to the scalp to affect mostly cortical neurons. tACS is supposed to modulate brain function and, in turn, cognitive processes by entraining brain oscillations and inducing long-term synaptic plasticity. Therefore, tACS has been investigated in cognitive neuroscience, but only recently, it has been also introduced in psychiatric clinical trials. This review describes current concepts and first findings of applying tACS as a potential therapeutic tool in the field of psychiatry. The current understanding of its mechanisms of action is explained, bridging cellular neuronal activity and the brain network mechanism. Revisiting the relevance of altered brain oscillations found in six major psychiatric disorders, putative targets for the management of mental disorders using tACS are discussed. A systematic literature search on PubMed was conducted to report findings of the clinical studies applying tACS in patients with psychiatric conditions. In conclusion, the initial results may support the feasibility of tACS in clinical psychiatric populations without serious adverse events. Moreover, these results showed the ability of tACS to reset disturbed brain oscillations, and thus to improve behavioural outcomes. In addition to its potential therapeutic role, the reactivity of the brain circuits to tACS could serve as a possible tool to determine the diagnosis, classification or prognosis of psychiatric disorders. Future double-blind randomised controlled trials are necessary to answer currently unresolved questions. They may aim to detect response predictors and control for various confounding factors.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Altered Brain Oscillations and Tacs Applications In Psychiatmentioning

confidence: 99%

See 3 more Smart Citations

Transcranial alternating current stimulation (tACS): from basic mechanisms towards first applications in psychiatry

Elyamany

Leicht

Herrmann

et al. 2020

Eur Arch Psychiatry Clin Neurosci

163

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Transkranielle elektrische Hirnstimulationsverfahren zur Behandlung der Negativsymptomatik bei Schizophrenie

Haller¹,

Hasan

Padberg³

et al. 2021

Nervenarzt

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ZusammenfassungÜber die letzten Jahre entwickelten sich Neuromodulationsverfahren zu einer dritten Säule neben Pharmakotherapie und Psychotherapie in der Behandlung psychischer Erkrankungen. Besonders in der Behandlung von Menschen mit einer Schizophrenie könnten Hirnstimulationsverfahren eine Alternative oder Ergänzung zu den etablierten Therapiestrategien darstellen. Die meist vorhandenen Positivsymptome können zumeist mit Antipsychotika adäquat behandelt werden. Gerade bei Patienten mit Schizophrenie besitzen jedoch Negativsymptome einen überdauernden Krankheitswert und beeinflussen den Verlauf durch globale Antriebsverarmung und beeinträchtigte Kognition im alltäglichen Leben negativ. Dieser Übersichtsartikel stellt eine Zusammenfassung über die verschiedenen nichtinvasiven Hirnstimulationsverfahren transkranielle Gleichstromstimulation (transcranial direct current stimulation, tDCS), Wechselstromstimulation (transcranial alternating current stimulation, tACS) sowie Rauschstromstimulation (transcranial random noise stimulation, tRNS) zur Behandlung der Negativsymptomatik bei Schizophrenie dar. Die neuen transkraniellen Hirnstimulationsverfahren könnten dabei helfen, gestörte neuronale Vernetzungen wieder herzustellen und die Konnektivität vor allem der dorsolateralen präfrontalen Anteile des Kortex zu verbessern. Einige Studien weisen auf eine Verbesserung der Negativsymptome durch Behandlung mit tDCS, tACS bzw. tRNS hin und könnten so neue Therapiemöglichkeiten in der Behandlung der Schizophrenie darstellen.

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Transcranial alternating current stimulation in affecting cognitive impairment in psychiatric disorders: a review

Biačková,

Adamová,

Klírová

2023

Eur Arch Psychiatry Clin Neurosci

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Transcranial alternating current stimulation (tACS) is a non-invasive brain stimulation method that, through its manipulation of endogenous oscillations, can affect cognition in healthy adults. Given the fact that both endogenous oscillations and cognition are impaired in various psychiatric diagnoses, tACS might represent a suitable intervention. We conducted a search of Pubmed and Web of Science databases and reviewed 27 studies where tACS is used in psychiatric diagnoses and cognition change is evaluated. TACS is a safe and well-tolerated intervention method, suitable for multiple-sessions protocols. It can be administered at home, individualized according to the patient'’s anatomical and functional characteristics, or used as a marker of disease progression. The results are varying across diagnoses and applied protocols, with some protocols showing a long-term effect. However, the overall number of studies is small with a great variety of diagnoses and tACS parameters, such as electrode montage or used frequency. Precise mechanisms of tACS interaction with pathophysiological processes are only partially described and need further research. Currently, tACS seems to be a feasible method to alleviate cognitive impairment in psychiatric patients; however, a more robust confirmation of efficacy of potential protocols is needed to introduce it into clinical practise.

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Feasibility of Online Neuromodulation Using Transcranial Alternating Current Stimulation in Schizophrenia

Cited by 24 publications

References 13 publications

Transcranial alternating current stimulation (tACS): from basic mechanisms towards first applications in psychiatry

Transcranial alternating current stimulation (tACS): from basic mechanisms towards first applications in psychiatry

Transkranielle elektrische Hirnstimulationsverfahren zur Behandlung der Negativsymptomatik bei Schizophrenie

Transcranial alternating current stimulation in affecting cognitive impairment in psychiatric disorders: a review

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