Feasibility of Patient Specific Aortic Blood Flow CFD Simulation

Svensson, Johan; Gårdhagen, Roland; Heiberg, Einar; Ebbers, Tino; Loyd, Dan; Länne, Toste; Karlsson, Matts

doi:10.1007/11866565_32

Cited by 15 publications

(10 citation statements)

References 15 publications

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“…In testing our hypothesis, we focused on the ascending aorta because it is the region of highest dynamic pressure. In comparison, there is relatively low pressure at the aortic valve (with some pressure being relieved by the branching of the coronary arteries at this level) (24). These differences in arterial pressure likely account for the most striking structural changes observed in our most distal segment because the first aortic segment analyzed was at the level of the aortic valves.…”

Section: Aortic Injurymentioning

confidence: 85%

Preterm birth with antenatal corticosteroid administration has injurious and persistent effects on the structure and composition of the aorta and pulmonary artery

et al. 2011

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INTRODUCTION:Preterm birth affects 8-12% of live births and is associated with the development of elevated arterial blood pressure and aortic narrowing in later life; this suggests that preterm birth may alter the development of arteries. Our objective was to determine the effects of preterm birth, accompanied by antenatal corticosteroid administration, on the structure of the aorta and pulmonary artery, which experience different alterations in pressure flow at birth. RESULTS: at 11 wk, preterm lambs had significantly thicker aortic walls and a smaller lumen, whereas the morphometry of the pulmonary artery was unaffected. elastin deposition was markedly increased in the aorta and pulmonary artery and smooth muscle content was reduced in the aorta only. In preterm lambs we found injury in the aorta only; controls were unaffected. DISCUSSION: We conclude that moderate preterm birth after antenatal betamethasone can cause injury and persistent alterations in the structure and composition of the aorta, with lesser effects in the pulmonary artery. Our findings suggest that preterm birth may increase the risk of atherosclerosis and aortic aneurysms in later life. METHODS:Using an established ovine model of preterm birth, lambs were born at 0.9 of gestation and underwent necropsy at 11 wk after birth; controls were born at term.

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Section: Aortic Injurymentioning

confidence: 85%

Preterm birth with antenatal corticosteroid administration has injurious and persistent effects on the structure and composition of the aorta and pulmonary artery

et al. 2011

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“…The algorithm was implemented into a cardiac image analysis software package [Heiberg et al, 2010]. The segmentation software gave a STL-representation of the inner aortic wall which set the boundary for the fluid domain [Svensson et al, 2006]. …”

Section: Mri Acquisition and Segmentationmentioning

confidence: 99%

Wall Shear Stress in a Subject Specific Human Aorta — Influence of Fluid-Structure Interaction

Lantz

Renner

Karlsson

2011

Int. J. Appl. Mechanics

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138

106

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shear stress (WSS) has been correlated to the development of atherosclerosis in arteries. As WSS depends on the blood flow dynamics, it is sensitive to pulsatile effects and local changes in geometry. The aim of this study is therefore to investigate if the effect of wall motion changes the WSS or if a rigid wall assumption is sufficient. Magnetic resonance imaging (MRI) was used to acquire subject specific geometry and flow rates in a human aorta, which were used as inputs in numerical models. Both rigid wall models and fluid-structure interaction (FSI) models were considered, and used to calculate the WSS on the aortic wall. A physiological range of different wall stiffnesses in the FSI simulations was used in order to investigate its effect on the flow dynamics. MRI measurements of velocity in the descending aorta were used as validation of the numerical models, and good agreement was achieved. It was found that the influence of wall motion was low on time-averaged WSS and oscillating shear index, but when regarding instantaneous WSS values the effect from the wall motion was clearly visible. Therefore, if instantaneous WSS is to be investigated, a FSI simulation should be considered.

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“…In the past, most patient-specific computational fluid dynamics (CFD) analyses of flow in the larger arteries, healthy aorta, aortic aneurysms, and carotid disease have been made under the laminar flow assumption (e.g., Leuprecht et al [11], Jin et al [12], and Svensson et al [13]) or, if turbulence is considered, with a turbulence model without explicit transition modeling (Khanafer and Berguer [14] and Benim et al [15]). However, from the experimental data above, it seems important to simulate transition to turbulence and its effects in such studies.…”

Section: Introductionmentioning

confidence: 99%

A Numerical Study of Aortic Flow Stability and Comparison With In Vivo Flow Measurements

Kousera

Wood

Seed

et al. 2012

Journal of Biomechanical Engineering

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The development of an engineering transitional turbulence model and its subsequent evaluation and validation for some diseased cardiovascular flows have been suggestive of its likely utility in normal aortas. The existence of experimental data from human aortas, acquired in the early 1970s with catheter-mounted hot film velocimeters, provided the opportunity to compare the performance of the model on such flows. A generic human aorta, derived from magnetic resonance anatomical and velocity images of a young volunteer, was used as the basis for varying both Reynolds number (Re) and Womersley parameter (α) to match four experimental data points from human ascending aortas, comprising two with disturbed flow and two with apparently undisturbed flow. Trials were made with three different levels of inflow turbulence intensity (Tu) to find if a single level could represent the four different cases with 4000 < Re < 10,000 and 17 < α < 26. A necessary boundary condition includes the inflow "turbulence" level, and convincing results were obtained for all four cases with inflow Tu = 1.0%, providing additional confidence in the application of the transitional model in flows in larger arteries. The Reynolds-averaged Navier-Stokes (RANS)-based shear stress transport (SST) transitional model is capable of capturing the correct flow state in the human aorta when low inflow turbulence intensity (1.0%) is specified.

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Feasibility of Patient Specific Aortic Blood Flow CFD Simulation

Cited by 15 publications

References 15 publications

Preterm birth with antenatal corticosteroid administration has injurious and persistent effects on the structure and composition of the aorta and pulmonary artery

Preterm birth with antenatal corticosteroid administration has injurious and persistent effects on the structure and composition of the aorta and pulmonary artery

Wall Shear Stress in a Subject Specific Human Aorta — Influence of Fluid-Structure Interaction

A Numerical Study of Aortic Flow Stability and Comparison With In Vivo Flow Measurements

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