Feasibility of Pediatric Plasma Apheresis in Intensive Care Settings

Abstract

Therapeutic plasma apheresis or exchange (TPE) in the pediatric population is technically challenging. Moreover, there is generally an apprehension in using TPE in children compared to adults. Recently, usage of TPE has evolved and is now being used in heterogenous clinical conditions. Its usefulness is classified by the American Society for Apheresis (ASFA) into various categories ranging from I to IV. The objective of this paper was to review the procedure in context of clinical indications, complications and outcomes in children. For this purpose, we retrospectively reviewed all TPE procedures performed on inpatients of 3 to 16 years of age during a 6-year period (2007-2012). A total of 130 procedures were performed on 28 patients (M : F ratio of 1:1) with median age (range) of 8.8 (4-16) years. All procedures were done using the continuous cell-separator centrifugal method. Due to organ dysfunctions, the majority of procedures (N = 26 of 28 or 92% patients) were performed in the pediatric intensive care unit. Twenty-three, four and one patient belonged to ASFA categories I, II and III, respectively. The most common indications were neurological disorders (N = 13 or 46.4%), comprised of Guillain-Barré syndrome (N = 10) and myasthenia gravis (N = 3). Hematological disorders (N = 10 or 35.7%) including thrombotic thrombocytopenic purpura-hemolytic uremic syndrome were a close second. Complete recovery was seen in 23 patients (84%). Trivial adverse effects were observed in 18/130 (13.8%) procedures. Major complications including cardiac arrest, hypotension and transfusion-related acute lung injury were observed in 5/130 or 3.8% of procedures. However, there was no procedure-related death though five patients died during treatment due to underlying pathology. In conclusion, TPE is a safe and effective option in sick children for appropriate indications. An experienced staff with sound procedural skills is imperative for successful therapy.

Therapeutic plasma exchange in paediatric neurology: a critical review and proposed treatment algorithm

“…7,32,66 Citrate is generally preferred to heparin, which confers a greater risk of bleeding. Citrate produces its anticoagulant effect by chelation of ionized calcium; it is rapidly cleared in the body in patients with normal hepatic and renal function and causes minimal systemic anticoagulation, but commonly causes hypocalcaemia.…”

Plasmapheresis; An Experience in Blood Bank of a Tertiary Care Hospital in Peshawar

“…9 Another study reported that the most common indications for plasmaphersis in their study were neurological disorders (n = 13), comprised of Guillain-Barré syndrome GBS (n= 10) and myasthenia gravis MG (N = 3), ten cases of Hematological disorders where plasmapheresis conducted for therapeutic purposes were thrombotic thrombocytopenic purpura (TTP)-hemolytic uremic syndrome (HUS) etc. 10 Mysthenia gravis was main disease noted in our study. These were the patients who were admitted for thymectomy in the cardiothoracic unit.…”

Flebogamma® 5 % DIF Intravenous Immunoglobulin for Replacement Therapy in Children with Primary Immunodeficiency Diseases

“…Of note, these AEs occurred during or within 1 h of infusion suggesting that the difference might be attributed to activities children carry out during infusion that adults would not (i.e., playing video games) [23,24]. Another possibility could be that children vital signs fluctuate more than adults as a consequence of apprehension brought on by being in the infusion center or hospital or as a result of the presence of nurses frequently taking their vital signs [25,26]. In addition, the difference may be due to a possibly higher likelihood that AEs are reported in a pediatric population as a result of parents being more cautious and attentive with their children than adults are with themselves [27,28].…”