Feasibility of Pencil Beam Scanned Intensity Modulated Proton Therapy in Breath-hold for Locally Advanced Non-Small Cell Lung Cancer

Gorgisyan, Jenny; Rosenschöld, Per Munck af; Perrin, Rosalind; Persson, G.; Josipović, Mirjana; Belosi, M.F.; Engelholm, Svend Aage; Weber, Damien Charles; Lomax, Anthony

doi:10.1016/j.ijrobp.2017.08.023

Cited by 37 publications

(53 citation statements)

References 35 publications

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“…Treatment was deliverable in less than or equal to 3 breath holds in 9 patients. For larger tumors (>200 cm 3 ), treatment with BH was unfeasible due to long beam delivery times [80]. However, the beam delivery time varies according to PBS system design and accelerator type; therefore, the feasibility needs to be determined at each individual PTS system.…”

Section: ) Abdominal Compressionmentioning

confidence: 99%

Current status of proton therapy techniques for lung cancer

Han

2019

Radiat Oncol J

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Proton beams have been used for cancer treatment for more than 28 years, and several technological advancements have been made to achieve improved clinical outcomes by delivering more accurate and conformal doses to the target cancer cells while minimizing the dose to normal tissues. The state-of-the-art intensity modulated proton therapy is now prevailing as a major treatment technique in proton facilities worldwide, but still faces many challenges in being applied to the lung. Thus, in this article, the current status of proton therapy technique is reviewed and issues regarding the relevant uncertainty in proton therapy in the lung are summarized.

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Section: ) Abdominal Compressionmentioning

confidence: 99%

Current status of proton therapy techniques for lung cancer

Han

2019

Radiat Oncol J

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“…This is also true for breath hold techniques. However, breath hold has been suggested to provide an efficient way to deliver high‐quality plans, as long as the plans can be delivered within a few breath holds . Many of the mentioned techniques could be used in combination to provide a higher level of interplay effect mitigation.…”

Section: Introductionmentioning

confidence: 99%

4D robust optimization including uncertainties in time structures can reduce the interplay effect in proton pencil beam scanning radiation therapy

2018

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“…For instance, fast energy changes allow volumetric rescanning of moving targets to be applied in an efficient way (Klimpki et al 2018). Other motion mitigation techniques, such as breath-hold or gating, as well as their combinations, also become more efficient with increased treatment delivery speed (Gorgisyan et al 2017, Rietzel & Bert 2010.…”

Section: Introductionmentioning

confidence: 99%

Large energy acceptance gantry for proton therapy utilizing superconducting technology

et al. 2019

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When using superconducting (SC) magnets in a gantry for proton therapy, the gantry will benefit from some reduction in size and a large reduction in weight. In this contribution we show an important additional advantage of SC magnets in proton therapy treatments. We present the design of a gantry with a SC bending section and achromatic beam optics with a very large beam momentum acceptance of ±15%. Due to the related very large energy acceptance, approximately 70% of the treatments can be performed without changing the magnetic field for synchronization with energy modulation. In our design this is combined with a 2D lateral scanning system and a fast degrader mounted in the gantry, so that this gantry will be able to perform pencil beam scanning with very rapid energy variations at the patient, allowing a significant reduction of the irradiation time.We describe the iterative process we have applied to design the magnets and the beam transport, for which we have used different codes. COSY Infinity and OPAL have been used to design the beam transport optics and to track the particles in the magnetic fields, which are produced by the magnets designed in Opera. With beam optics calculations we have derived an optimal achromatic beam transport with the large momentum acceptance of the proton pencil beam and we show the agreement with particle tracking calculations in the 3D magnetic field map.A new cyclotron based facility with this gantry will have a significantly smaller footprint, since one can refrain from the degrader and energy selection system behind the cyclotron. In the treatments, this gantry will enable a very fast proton beam delivery sequence, which may be of advantage for treatments in moving tissue.

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Feasibility of Pencil Beam Scanned Intensity Modulated Proton Therapy in Breath-hold for Locally Advanced Non-Small Cell Lung Cancer

Cited by 37 publications

References 35 publications

Current status of proton therapy techniques for lung cancer

Current status of proton therapy techniques for lung cancer

4D robust optimization including uncertainties in time structures can reduce the interplay effect in proton pencil beam scanning radiation therapy

Large energy acceptance gantry for proton therapy utilizing superconducting technology

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