Feasibility of Radiosurgery for Malignant Brain Tumors in Infants by Use of Image-guided Robotic Radiosurgery: Preliminary Report

Giller, Cole A.; Berger, Brian D.; Gilio, Joseph P.; Delp, Janice L.; Gall, Kenneth P.; Weprin, Bradley E.; Bowers, Daniel C.

doi:10.1227/01.neu.0000137332.03970.57

Cited by 24 publications

(13 citation statements)

References 39 publications

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“…A variety of fractionation schemes have been used in adult spinal stereotactic radiotherapy with fraction doses ranging from 6 to 30 Gy in 1 to 5 fractions, and rare severe radiation dose-related myelopathy was identified in this range1,5,6). Nevertheless, the tolerability and feasibility of hypofractionated radiotherapy in children is rarely reported and limited to pediatric CNS tumors7,8). To our knowledge, this is the first report of Cyberknife® stereotactic hypofractionated radiotherapy in childhood spinal metastasis.…”

Section: Discussionmentioning

confidence: 95%

Successful Treatment of Infantile Fibrosarcoma Spinal Metastasis by Chemotherapy and Stereotactic Hypofractionated Radiotherapy

Cheng

Lin

et al. 2013

J Korean Neurosurg Soc

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We report a case of infantile fibrosarcoma in an 8-month-old boy manifested as a right-sided lower leg mass. Repeated local recurrence and distant metastasis were noted during the following three-year period. Whole body fluoro-deoxyglucose positron emission tomography scan revealed an asymptomatic metastasis involving the fourth lumbar vertebrae. The patient received chemotherapy (VAC regimen) with Cyberknife® stereotactic hypofractionated radiotherapy (26 Gy; 4 fractions). This treatment reduced tumor size by 23% without acute radiation toxicity even after 33 months. This case suggests that combining chemotherapy and this form of radiotherapy may be safe and effective against childhood spinal metastasis.

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Section: Discussionmentioning

confidence: 95%

Successful Treatment of Infantile Fibrosarcoma Spinal Metastasis by Chemotherapy and Stereotactic Hypofractionated Radiotherapy

Cheng

Lin

et al. 2013

J Korean Neurosurg Soc

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“…More than 10,000 patients have been treated [19][20][21]. Currently, the most significant developments are in the field of extracranial stereotactic radiotherapy [22][23][24][25][26].…”

Section: Clinical Results With the Cyberknifementioning

confidence: 99%

Extracranial Stereotactic Radiotherapy: Preliminary Results with the CyberKnife®

et al. 2009

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In the field of radiation oncology, equipment for fractionated radiotherapy and single-dose radiosurgery has become increasingly accurate, together with the introduction of robotized treatments. A robot is a device that can be programmed to carry out accurate, repeated and ad-justed tasks in a given environment. Treatment of extracranial lesions involves taking into account organ mobility (tumor and healthy tissue) whilst retaining the ability to stereotactically locate the target. New imaging techniques (single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), positron emission tomography (PET)) provide further relevant information to slice images (computed tomography (CT) scans, MRI) for target definition. Hypo-fractionated treatments can only be used for curative treatment if the target is accurately defined and tracked during treatment. The CyberKnife^® is a non-invasive system of radiosurgery and fractionated stereotactic radiotherapy. For intracranial lesions treated by single-dose radiosurgery, it has been used to treat meningioma, acoustic neuromas, pituitary adenoma, metastases, arteriovenous malformations and refractory pain (trigeminal neuralgia). More than 10,000 patients have been treated worldwide. Currently, the most significant developments are in the field of extracranial stereotactic radiotherapy (lung, liver, reirradiation, prostate, etc.). Clinical results obtained in the Cyberknife Nord-Ouest program after 1 year of experience are presented.

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“…Les dé veloppements actuellement les plus significatifs se font dans le cadre de la sté ré otaxie extracrâ nienne [13,15,16,27,31,36].…”

Section: Ré Sultats Cliniquesunclassified

Extracranial stereotactic radiotherapy: the role of the CyberKnife®

et al. 2007

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Site internet : www.centreoscarlambret.fr, www.ckno.fr Ré sumé : En 2006, l'Institut national du cancer a lancé un appel d'offres portant sur la radiothé rapie sté ré otaxique extracrâ nienne. Trois sites (Lille, Nancy et Nice) ont é té sé lectionné s pour implanter et é valuer un robot de radiothé rapie, le CyberKnife ® . Cette machine capable de suivre des tumeurs mobiles en temps ré el ouvre de nouvelles perspectives dans le champ de la radiothé rapie sté ré otaxique, notamment dans sa composante extracrâ nienne. Les fonctionnalité s de cet é quipement et le coû t de sa mise en oeuvre vont ê tre é valué s sur une pé riode de deuxanssurlestroissitesconsidé ré s.Mots clé s : Radiothé rapie sté ré otaxique extracrâ nienne -RobotCyberKnife ® Extracranial stereotactic radiotherapy: the role of the CyberKnife ® Abstract: In 2006, three sites were selected by the French Institut national du cancer (Lille, Nancy and Nice) to evaluate the CyberKnife robotic radiotherapy system. This device, able to track mobile tumours in real time, offers new possibilities in the field of extracranial stereotactic radiotherapy. The device's functionalities, as well as medical and economical issues, will be evaluated for two years on the three sites.

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Feasibility of Radiosurgery for Malignant Brain Tumors in Infants by Use of Image-guided Robotic Radiosurgery: Preliminary Report

Abstract: Radiosurgery with minimal toxicity can be delivered to infants by use of a robotically controlled system that does not require rigid fixation. A formal dose-escalation trial is under way to address dose and toxicity for infants more thoroughly.

Cited by 24 publications

References 39 publications

Successful Treatment of Infantile Fibrosarcoma Spinal Metastasis by Chemotherapy and Stereotactic Hypofractionated Radiotherapy

Successful Treatment of Infantile Fibrosarcoma Spinal Metastasis by Chemotherapy and Stereotactic Hypofractionated Radiotherapy

Extracranial Stereotactic Radiotherapy: Preliminary Results with the CyberKnife®

Extracranial stereotactic radiotherapy: the role of the CyberKnife®

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