Feasibility of semiquantitative liver perfusion assessment by ferucarbotran bolus injection in double‐contrast hepatic MRI

Abstract

Purpose: To evaluate the feasibility of semiquantitative measurement of liver perfusion from analysis of ferucarbotran induced signal-dynamics in double-contrast liver MR-imaging (DC-MRI). Materials and Methods:In total 31 patients (21 men; 58 6 10 years) including 18 patients with biopsy proven liver cirrhosis prospectively underwent clinically indicated DC-MRI at 1.5 Tesla (T) with dynamic T2*-weighted gradientecho imaging after ferucarbotran bolus injection. Breathing artefacts in tissue and input time curves were reduced by Savitzky-Golay-filtering and semiquantitative perfusion maps were calculated using a model free approach. Hepatic blood flow index (HBFI) and splenic blood flow index (SBFI) were determined by normalization of arbitrary perfusion values to the perfusion of the erector spinae muscle resulting in a semiquantitative perfusion measure.Results: In 30 of 31 patients the evaluated protocol could successfully be applied. Mean HBF was 7.7 6 2.46 (range, 4.6-12.8) and mean SBF was 13.20 6 2.57 (range, 8.5-17.8). A significantly lower total HBF was seen in patients with cirrhotic livers as compared to patients with noncirrhotic livers (P < 0.05). In contrast, similar SBF was observed in cirrhotic and noncirrhotic patients (P ¼ 0.11).Conclusion: Capturing the signal dynamics during bolus injection of ferucarbotran in DC-MRI of the liver allows for semiquantitative assessment of hepatic perfusion that may be helpful for a more precise characterisation of liver cirrhosis and focal liver lesions.

Liver fibrosis and Gd-EOB-DTPA-enhanced MRI: A histopathologic correlation

“…However, based on various clinical and biochemical parameters, the uptake of Gd-EOB-DTPA depends on liver function16171819202122. The underlying liver pathology that causes the delayed uptake of Gd-EOB-DTPA has not been thoroughly examined.…”

The correlation between magnetic resonance diffusion parameters and Ki-67 and PCNA in hepatic fibrosis and cirrhosis rats

“…According to the results, the ADC value, which was used to diagnose and evaluate hepatic fibrosis, exhibited the highest accuracy when the b parameter was set at 400 s/mm 2 . However, Fischer et al (12) found that MR-DWI contributed to the early diagnosis of rat hepatic fibrosis, and the desirable b value should be 600 or 800 s/mm 2 . In this study, when the b parameter was set at 600 s/mm 2 , there was a better correlation between the pathological grade of liver fibrosis and the ADC value.…”

“…PCNA and Ki-67 are mature markers indicating cell proliferation, and in recent years they have been mainly utilized in various kinds of cancer research (4,5,8,12). High expression of PCNA reveals abundant synthesis of DNA in cells, which makes PCNA an excellent biomarker in the synthesis phase.…”

A Fast Nonlinear Regression Method for Estimating Permeability in CT Perfusion Imaging

“…8 A gamma variate fit gives a robust estimate of the area under the curve (AUC) and TTP of the first-pass bolus in the attenuation-time curve. [14][15][16] Subsequently, the CBV can be estimated by dividing the AUC of the tissue curve by the AUC of the AIF. 10 The bolus arrival time (BAT), which is in this study used to define the start of contrast enhancement, is defined as the 0.05% quantile of the gamma variate fit ( Figure 1B).…”