Feasibility of state of the art PET/CT systems performance harmonisation

Kaalep, Andres; Séra, Teréz; Rijnsdorp, Sjoerd; Yaqub, Maqsood; Talsma, Anne; Lodge, Martin A.; Boellaard, Ronald

doi:10.1007/s00259-018-3977-4

Cited by 124 publications

(152 citation statements)

References 48 publications

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“…Therefore, we expect in the coming years that, besides hardware developments like digital TOF, postprocessing developments like the implementation of BPL algorithms will enhance the performance of PET at a similar pace as we have seen the last decade. Likely, the EANM will have to continue updating the EARL min-max accreditation limits to keep up with these developments, as they did over the last decade [8,9].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, initiatives like the European EARL accreditation system help to set up a methodology to compare results of different institutes and PET/CT scanners by narrowing the SUV results and making them reproducible over time [3,8]. New developments in the hardware of PET/CT scanners and reconstruction methods available force these EARL criteria to be updated frequently [9]. Most modern PET/CT scanners have implemented reconstruction algorithms that were developed over the last decades, applying time of flight (TOF) information and point spread function (PSF) modelling [10].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of a Bayesian penalized likelihood reconstruction algorithm for low-count clinical 18F-FDG PET/CT

et al. 2019

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Background: Recently, a Bayesian penalized likelihood (BPL) reconstruction algorithm was introduced for a commercial PET/CT with the potential to improve image quality. We compared the performance of this BPL algorithm with conventional reconstruction algorithms under realistic clinical conditions such as daily practiced at many European sites, i.e. low 18 F-FDG dose and short acquisition times. Results: To study the performance of the BPL algorithm, regular clinical 18 F-FDG whole body PET scans were made. In addition, two types of phantoms were scanned with 4-37 mm sized spheres filled with 18 F-FDG at sphere-to-background ratios of 10-to-1, 4-to-1, and 2-to-1. Images were reconstructed using standard ordered-subset expectation maximization (OSEM), OSEM with point spread function (PSF), and the BPL algorithm using β-values of 450, 550 and 700. To quantify the image quality, the lesion detectability, activity recovery, and the coefficient of variation (COV) within a single bed position (BP) were determined. We found that when applying the BPL algorithm both smaller lesions in clinical studies as well as spheres in phantom studies can be detected more easily due to a higher SUV recovery, especially for higher contrast ratios. Under standard clinical scanning conditions, i.e. low number of counts, the COV is higher for the BPL (β=450) than the OSEM+PSF algorithm. Increase of the β-value to 550 or 700 results in a COV comparable to OSEM+PSF, however, at the cost of contrast, though still better than OSEM+PSF. At the edges of the axial field of view (FOV) where BPs overlap, COV can increase to levels at which bands become visible in clinical images, related to the lower local axial sensitivity of the PET/CT, which is due to the limited bed overlap of 23% such as advised by the manufacturer. Conclusions:The BPL algorithm performs better than the standard OSEM+PSF algorithm on small lesion detectability, SUV recovery, and noise suppression. Increase of the percentage of bed overlap, time per BP, administered activity, or the β-value, all have a direct positive impact on image quality, though the latter with some loss of small lesion detectability. Thus, BPL algorithms are very interesting for improving image quality, especially in small lesion detectability.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of a Bayesian penalized likelihood reconstruction algorithm for low-count clinical 18F-FDG PET/CT

et al. 2019

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“…A limitation of both the qPET method and the DS is their sensitivity to differences in scan reconstructions and voxel sizes [5]. Efforts are currently being made to update harmonizing standards that will allow the impact of newer reconstruction methods on image interpretation to be assessed [34,35]. Standardisation of patient preparation, scan acquisition and reconstruction parameters is required but this applies to both visual and quantitative assessment of response [36].…”

Section: Discussionmentioning

confidence: 99%

“…Recent data suggest that advanced image reconstructions (e.g. PSF, qCLEAR) over-estimate maximum SUV values compared to peak and mean SUV values [35]. Hence peak SUV has recently been proposed instead of maximum SUV for assessing tumour activity.…”

Section: Discussionmentioning

confidence: 99%

Quantitative assessment of interim PET in Hodgkin lymphoma: An evaluation of the qPET method in adult patients in the RAPID trial

et al. 2020

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AimqPET is a quantitative method used to assess FDG-PET response in lymphoma. qPET was developed using 898 scans from children with Hodgkin Lymphoma (HL) in the EuroNet-PHL-C1 (C1) trial. The aim of this study was to determine if qPET could be applied as an alternative response method in adults in the RAPID trial. MethodsPET-CT scans performed after 3 cycles of ABVD in RAPID were re-evaluated by an independent reader, blinded to PET results and outcome in RAPID. All initially involved regions were assessed visually and by qPET. The distribution of qPET measurements was compared for RAPID and C1 patients. Previously published qPET thresholds corresponding to visual DS (vDS) of 1-5 in C1 were used to derive quantitative DS (qDS) for RAPID patients. ResultsPET-CT scans were available for 450 patients from RAPID. vDS were 1 (171 scans), 2 (153 scans), 3 (72 scans), 4 (31 scans) and 5 (23 scans) respectively. The distribution of qPET values was similar to C1 patients, with a unimodal 'normal' distribution and a long tail to the right, suggestive of favorable response in the majority and less favorable response in the minority with outlying values. qPET thresholds from C1 applied in RAPID patients gave 86% concordance for vDS and qDS. There was 97% concordance for complete metabolic response (CMR; DS 1-3) vs. no-CMR using the Lugano classification. ConclusionqPET which was developed in pediatric patients receiving more intensive OEPA chemotherapy, was a suitable quantitative method for assessing response in adult patients treated with ABVD in a response-adapted setting in the RAPID trial. PLOS ONEqPET in RAPID trial patients PLOS ONE | https://doi.

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“…One important topic is to harmonize readouts to establish clinical standards in particular for the quantification of molecular processes, which is one of the advantages of nuclear imaging methods. Kaalep et al [3] (Tallinn, Estonia) presented a collaborative study (several European and one US centre) investigating the feasibility of harmonizing the performance of state-of-the-art PET/CT systems. They performed phantom studies on the newest time of flight (ToF) PET/CT systems available with resolution modelling/point spread function (PSF) technologies, and showed that it is possible to harmonize the systems’ retard, which may provide the basis for a wider study of system harmonization.…”

Section: Physics and Instrumentationmentioning

confidence: 99%

Highlights of the 30th Annual Congress of the EANM, Vienna 2017: “Yes we can – make nuclear medicine great again”

Fanti

Bonfiglioli

Decristoforo

2018

Eur J Nucl Med Mol Imaging

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The 30th Annual Congress of the European Association of Nuclear Medicine (EANM) was held in Vienna, Austria, from 21 to 25 October 2017 under the chairmanship of Professor Francesco Giammarile. As always, the Congress was a great success: more than 6,379 participants came from 90 countries from all continents. Participants were presented with an excellent programme consisting of symposia, and scientific and featured sessions, CME sessions, and plenary lectures. These lectures were devoted to nuclear medicine imaging and therapy, including hybrid imaging and molecular life sciences. Additionally, the latest technology and innovations in the field were presented, and added to the success of the Congress. This review summarizes the major scientific contributions which were selected from more than 1,900 submitted abstracts, and presented in the closing highlights session. They cover the diverse areas of nuclear medicine, with particular focus on oncology, cardiovascular science, neurology, technological innovation and novel tracers, and also other clinical sciences. A particular focus of the Congress was on targeted radionuclide-based therapies, which all show promising and great innovations. The Congress was a unique opportunity to be thoroughly updated on this research. This Highlights Lecture could only be a brief summary of the large amount of data presented and discussed during the meeting, which can be found in much greater detail in the Congress proceedings book, published as volume 44, supplement 2 of the European Journal of Nuclear Medicine and Molecular Imaging in October 2017.

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Feasibility of state of the art PET/CT systems performance harmonisation

Cited by 124 publications

References 48 publications

Evaluation of a Bayesian penalized likelihood reconstruction algorithm for low-count clinical 18F-FDG PET/CT

Evaluation of a Bayesian penalized likelihood reconstruction algorithm for low-count clinical 18F-FDG PET/CT

Quantitative assessment of interim PET in Hodgkin lymphoma: An evaluation of the qPET method in adult patients in the RAPID trial

Highlights of the 30th Annual Congress of the EANM, Vienna 2017: “Yes we can – make nuclear medicine great again”

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