Feasibility of transrib focused ultrasound thermal ablation for liver tumors using a spherically curved 2D array: A numerical study

Liu, Hao-Li; Chang, Hsiu‐Hua; Chen, Wen-Shiang; Shih, Tien‐Tsorng; Hsiao, Jong‐Kai; Lin, Win-Li

doi:10.1118/1.2759888

Cited by 61 publications

(68 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar to Civale et al [23] but using 2D phased array, selective deactivation of emitting elements that fall in the shadow (conical projection) of the ribs has been investigated [24,25]. Adaptive focusing using multi-element transducer devices capable of working in both transmit and receive mode [26,27].…”

Section: Introductionmentioning

confidence: 99%

Spatio-temporal quantitative thermography of pre-focal interactions between high intensity focused ultrasound and the rib cage

Petrusca

Salomir

Manasseh

et al. 2015

International Journal of Hyperthermia

View full text Add to dashboard Cite

Objective: The aim of this paper is to quantitatively investigate the thermal effects generated by the pre-focal interactions of a HIFU beam with a rib cage, in the context of minimally invasive transcostal therapy of liver malignancies. Materials and methods: HIFU sonications were produced by a phased-array MR-compatible transducer on Turkey muscle placed on a sheep thoracic cage specimen. The thoracic wall was positioned in the pre-focal zone 3.5 to 6.5 cm below the focus. Thermal monitoring was simultaneously performed using fluoroptic sensors inserted into the medullar cavity of the ribs and high resolution MR-thermometry (voxel: 1 Â 1 Â 5 mm 3 , four multi-planar slices). Results: MR-thermometry data indicated nearly isotropic distribution of the thermal energy at the ribs' surface. The temperature elevation at the focus was comparable with the pericostal temperature elevation around unprotected ribs, while being systematically inferior, by more than a factor of four on average, to the intra-medullar values. The spatial profiles of the pericostal and intra-medullar thermal build-up measurements could be smoothly connected using a Gaussian function. The dynamics of the post-sonication thermal relaxation as determined by fluoroptic measurements was demonstrated to be theoretically coherent with the experimental observations. Conclusion: The experimental findings motivate further efforts for the transfer towards clinical routine of effective rib-sparing strategies for hepatic HIFU.

show abstract

Section: Introductionmentioning

confidence: 99%

Spatio-temporal quantitative thermography of pre-focal interactions between high intensity focused ultrasound and the rib cage

Petrusca

Salomir

Manasseh

et al. 2015

International Journal of Hyperthermia

View full text Add to dashboard Cite

show abstract

“…The maximum temperature reached by the tumour is 105. 17 C, while the maximum temperature reached by the …”

Section: Hifu Ablation Without Protectionmentioning

confidence: 99%

“…Bobkova et al [15] compared rib-sparing HIFU approaches to 'geometric' and 'diffraction' approaches. The earlier 'geometric' approaches switch off the transducers that are 'geometrically' obstructed by the ribs [16][17][18][19]. To account for the scattering, 'diffraction' approaches make use of the wave characteristics to further enhance focusing.…”

Section: Introductionmentioning

confidence: 99%

“…Bobkova et al took into account the diffraction effects and used a phase conjugation method to improve focusing and provide better protection of the ribs [15]. Simulation of transcostal HIFU involves the solution of the RayleighSommerfeld integral [17]. Gelat et al proposed the use of the boundary element approach, which is based on a generalised minimal residual implementation of the Burton-Miller formulation, to address the scattering and diffraction effects [22].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A novel sound-blocking structure based on the muffler principle for rib-sparing transcostal high-intensity focused ultrasound treatment

Chao

Hsu

et al. 2015

International Journal of Hyperthermia

View full text Add to dashboard Cite

(2015) A novel sound-blocking structure based on the muffler principle for rib-sparing transcostal high-intensity focused ultrasound treatment, International Journal of Hyperthermia, 31:5, 507-527, DOI: 10.3109/02656736.2015 AbstractThe main challenge in transcostal high-intensity focused ultrasound therapy is minimising heat deposition in the ribs while ensuring that a sufficient dose is delivered to the target region. Current approaches rely on expensive multichannel phased-array systems to turn the individual transducer on and off according to either geometrical arrangements or complicated wave calculations. To protect the ribs from heating, the ultrasound energy must not only not reach the ribs, but must also not accumulate in front of the ribs. The research in this paper proposes a different approach, of attaching a sound-blocking structure in front of the rib cage with similar effects to those of an engine exhaust muffler. The sound-blocking structure is based on the muffler principle to prevent ultrasound energy from reaching the ribs and reduce the amount of energy reflected back to the applicator. Finite element simulations with a 0.5-MHz transducer of the overall sound fields and temperature distribution showed that the ultrasound pressure and energy level would decrease behind the novel sound-blocking structures, thereby resulting in a lower temperature at the ribs than at the tumour. Without the protecting structure, the rib temperature reached 104.19 C whereas with the structure it reached only 37.86 C. An experimental set-up using porcine ribs with a phantom was also developed to validate the concept, which showed that the rib temperature reached 73 C without protection within 1 min of ablation time whereas it reached 36.5 C with the device. The tumour region in the tests reached 51C and 49 C with and without protection, respectively.

show abstract

“…In previous work, different methods have been suggested on how to determine such apodization laws, using CT or MRI-based identification of the thoracic cage. These methods include geometric raytracing [4,5], phase conjugation [6][7][8] and constrained optimization [9]. A major advantage of such methods is that they are in general very precise.…”

Section: Introductionmentioning

confidence: 99%

Cavitation-enhanced back projection for acoustic detection of attenuating structures

Ramaekers¹,

Greef²,

Moonen³

et al. 2017

AIP Conference Proceedings

View full text Add to dashboard Cite

Strategy of high efficiency and refined high-intensity focused ultrasound and ultrasound monitoring imaging of thermal lesion and cavitation AIP Conference Proceedings 1821, 060002 (2017) Abstract. Current methodology for the detection of attenuating structures in abdominal HIFU interventions requires lengthy, elaborate image analysis, which is undesired in a clinical setting. In this work, a method for the acoustic detection of attenuating structures in the beam path of the therapeutic HIFU array is described. The proposed method is used to determine binary apodizations that can be applied to the HIFU transducer for intercostal shot positions. Such a binary apodization was determined in vivo on an anesthetized pig under controlled breathing. Validation of the proposed method was done by comparing the binary apodization based on the proposed method to a binary apodization obtained using methodology based on MR image analysis and a collision detection algorithm. The proposed acoustical method provided a binary apodization that was over 90% similar to the apodization obtained using the image analysis-based method. Additionally, the proposed method can provide a measure of the amount of attenuation that each respective transducer element encounters in its beam path towards the focus.

show abstract

Feasibility of transrib focused ultrasound thermal ablation for liver tumors using a spherically curved 2D array: A numerical study

Cited by 61 publications

References 45 publications

Spatio-temporal quantitative thermography of pre-focal interactions between high intensity focused ultrasound and the rib cage

Spatio-temporal quantitative thermography of pre-focal interactions between high intensity focused ultrasound and the rib cage

A novel sound-blocking structure based on the muffler principle for rib-sparing transcostal high-intensity focused ultrasound treatment

Cavitation-enhanced back projection for acoustic detection of attenuating structures

Contact Info

Product

Resources

About