Feasibility, safety, and efficacy of ultrasound-guided transperineal laser ablation for the treatment of benign prostatic hyperplasia: a single institutional experience

Frego, Nicola; Saita, Alberto; Casale, Paolo; Diana, Pietro; Contieri, Roberto; Avolio, Pier Paolo; Lazzeri, Massimo; Hurle, Rodolfo; Buffi, Nicolò Maria; Guazzoni, Giorgio; Lughezzani, Giovanni

doi:10.1007/s00345-021-03685-7

Cited by 30 publications

(93 citation statements)

References 40 publications

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“…Soractelite™ transperineal focal laser ablation (TPLA) using the Echolaser® system is a novel minimally invasive thermoablative technique based on laser-tissue interaction that induces cell death. It has already been shown that this technique can be performed safely in treating patients with lower urinary tract symptoms due to benign prostatic obstruction [11] , [12] . Moreover, several pilot studies showed that the procedure is feasible using single fiber focal laser ablation (FLA) systems for the treatment of PCa under general anesthesia [13] , [14] , [15] .…”

Section: Introductionmentioning

confidence: 99%

Safety and Feasibility of Soractelite Transperineal Focal Laser Ablation for Prostate Cancer and Short-term Quality of Life Analysis from a Multicenter Pilot Study

Riel

Kollenburg

Vis

et al. 2022

European Urology Open Science

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Section: Introductionmentioning

confidence: 99%

Safety and Feasibility of Soractelite Transperineal Focal Laser Ablation for Prostate Cancer and Short-term Quality of Life Analysis from a Multicenter Pilot Study

Riel

Kollenburg

Vis

et al. 2022

European Urology Open Science

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“…Of note, none of the available systematic reviews in this field included data from TPLA, though different authors have already described its feasibility and safety in real-life settings (7)(8)(9)(10)(11)(12).…”

Section: Discussionmentioning

confidence: 99%

“…In this scenario, transperineal interstitial laser ablation of the prostate (TPLA) represents a novel option for minimally invasive treatment of BPO; although it is still not recommended by the latest European Association of Urology (EAU) Guidelines, it has shown promising results in terms of feasibility and safety (7)(8)(9)(10)(11)(12). Nevertheless, data in literature are still scarce regarding the best indications, functional outcomes and patient-reported outcomes after TPLA.…”

Section: Introductionmentioning

confidence: 99%

Transperineal laser ablation of the prostate with EchoLaser™ system: perioperative and short-term functional and sexual outcomes

et al. 2022

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ObjectiveTo date, several ultra-minimally-invasive surgical techniques are available for the treatment of male LUTS due to benign prostatic obstruction (BPO). Herein we report our preliminary experience with SoracteLite™ TPLA for the treatment of carefully selected patients with LUTS due to BPO.MethodsData from all consecutive patients undergoing TPLA at our institution between April 2021 and February 2022 were prospectively collected in a specific database. Data regarding functional and sexual outcomes evaluated by validated questionnaires and uroflowmetry were analyzed. All the procedure were performed in an outpatient setting, under local anesthesia and conscious sedation, using EchoLaser device, a multisource diode laser generator.ResultsOverall, 38 patients underwent TPLA at our institution during the study period. The median prostate volume was 46 ml (IQR 38-71). The median time to complete the procedure was 31 min (IQR 28-37). All patients but one were discharged within 8 hours of hospital stay. No perioperative Clavien-Dindo grade ≥2 complications were recorded. Median improvement in Qmax was 17%, 24% and 32% at 1 month, 3 months and last follow-up after surgery; as a result, the median postoperative IPSS at 1 month, 3 months and at last follow-up decreased by -14%, -36% and -35%, respectively. All patients preserved ejaculatory and sexual function. Two patients (5%), catheter carriers before the procedure, experienced acute urinary retention after TPLA treatment and required replacement of an indwelling catheter.ConclusionsTPLA can be a feasible, safe and effective ultra-minimally-invasive procedure for carefully selected patients with LUTS due to BPO.

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“…Somit ist die TPLA kein unmittelbar ablatives Verfahren, sondern führt im Verlauf zu einer Volumenreduktion der Prostata. Der Eingriff wird unter Sedierung, Lokalanästhesie der perinealen Region und transrektalem Prostatablock durchgeführt [49]. In der prospektiven, monozentrischen Studie von…”

Section: Intraprostatische Injektion Von Fexapotid-triflurtatunclassified

Minimal-invasive Therapie: Wie ist der Stand im Jahre 2021 – was kommt, was geht

2022

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ZusammenfassungDie Volkskrankheit „benignes Prostatasyndrom“ erfordert mit der Vielzahl an betroffenen Männern und einer variablen klinischen Präsentation individuelle Therapieoptionen, die auf die jeweiligen klinischen Charakteristika und Wünsche des Patienten zugeschnitten werden. Ist eine operative Therapie indiziert, steht ein großes Spektrum an invasiven Verfahren zur Verfügung. Als Goldstandard galten lange Zeit die transurethrale Resektion der Prostata und die offene Adenomenukleation, die jedoch mit erhöhter Morbidität und Einschränkungen der Sexualfunktion einhergehen. Daher wird zunehmend nach minimal-invasiven Therapieoptionen gefordert, die eine effektive und sichere Therapie im ambulanten Setting ermöglichen sollen. Über die letzten Jahre wurde eine Vielzahl an Technologien und Verfahren entwickelt und getestet, von denen nur wenige in der klinischen Praxis etabliert werden konnten, meist aufgrund unzureichender funktioneller Ergebnisse. Nicht mehr empfohlen werden daher die transurethrale Nadelablation, transurethrale Mikrowellentherapie, intraprostatische Botulinumtoxin-A- oder PRX302-Injektionen und prostatische Stents. Demgegenüber spricht die Europäische Gesellschaft für Urologie derzeit Empfehlungen für den UroLift, die Aquablation und die Prostataarterienembolisation aus, die langfristig signifikante Verbesserungen der funktionellen Parameter erreichen und dabei mit einem guten Sicherheitsprofil und erhaltener Sexualfunktion überzeugen. Vielversprechende Daten liegen auch für das temporär implantierte Nitinoldevice (iTIND), Rezūm, intraprostatische Injektionen von Fexapotid-Triflurtat und die transperineale Laserablation der Prostata vor, deren Effektivität und Sicherheit jedoch noch in weiteren Studien bestätigt werden müssen.

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Feasibility, safety, and efficacy of ultrasound-guided transperineal laser ablation for the treatment of benign prostatic hyperplasia: a single institutional experience

Cited by 30 publications

References 40 publications

Safety and Feasibility of Soractelite Transperineal Focal Laser Ablation for Prostate Cancer and Short-term Quality of Life Analysis from a Multicenter Pilot Study

Safety and Feasibility of Soractelite Transperineal Focal Laser Ablation for Prostate Cancer and Short-term Quality of Life Analysis from a Multicenter Pilot Study

Transperineal laser ablation of the prostate with EchoLaser™ system: perioperative and short-term functional and sexual outcomes

Minimal-invasive Therapie: Wie ist der Stand im Jahre 2021 – was kommt, was geht

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