Feasibility study of 3-T MR imaging of the skin

Aubry, S.; Casile, C.; Humbert, Philippe; Jehl, J.; Vidal, Chrystelle; Kastler, B.

doi:10.1007/s00330-009-1348-z

Cited by 25 publications

(43 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…MRI characterization of the skin has been performed in various studies, including skin morphology , biochemical properties and structure of the different layers , water mobility , Na + content , properties of inflammatory lesions and skin tumors , skin microvasculature and aging effects . However, the clinical usefulness of skin measurements with conventional MRI remains to be proven as a few main drawbacks severely limit the use of MRI as a skin imaging tool: (i) MRI equipment is expensive and its availability for skin examination is limited; (ii) skin MRI requires a high spatial resolution that demands high magnetic field gradients and sensitive (small) surface coils confined to the volume of interest ; (iii) the NMR signal from the skin consists of short relaxation times that require the use of short TEs .…”

Section: Introductionmentioning

confidence: 99%

In vivo assessment of aged human skin with a unilateral NMR scanner

et al. 2015

View full text Add to dashboard Cite

Human skin undergoes morphological and biochemical changes as a result of chronological aging and exposure to solar ultraviolet irradiation (photoaging). Noninvasive detection of these changes may aid in the prevention and treatment of both types of aging. This article presents a noninvasive method for the evaluation of aging skin with a unilateral stray field NMR scanner. These portable and inexpensive scanners may be suitable for in-depth skin characterization. In vivo profiles of sun-protected and sun-exposed skin from the forearms of female subjects of different ages (n = 9) were measured. Skin biopsies for histopathological examination were used as reference. T2 analysis with a bi-exponential decay model was applied and the extracted parameters were examined as markers for dermal aging. In the upper reticular dermis, a significant increase in the fraction of the slow T2 component and in the T2 value itself was found to correlate with chronological aging. For most subjects, there was an additional increase in the values of the slow T2 component and the T2 values from the sun-exposed forearm, superimposed on that measured for the sun-protected forearm. These results are in agreement with the decline in collagen content and the increase in free water content with aging. The results suggest that such a technique can be used as a tool for the assessment of aging, and that bi-exponential fitting can produce sensitive fingerprint parameters for the dermal alterations that occur during aging.

show abstract

Section: Introductionmentioning

confidence: 99%

In vivo assessment of aged human skin with a unilateral NMR scanner

et al. 2015

View full text Add to dashboard Cite

show abstract

“…In vivo skin imaging has been investigated at 0.5 T (2), 1.5 T (1, 3–12), 2 T (13), and 2.4 T (14). One feasibility study (36 volunteers) at 3 T has been recently published (15). To achieve high resolution, small (typically 1‐inch‐diameter) surface receiver coils are used.…”

mentioning

confidence: 99%

In vivo high-resolution magnetic resonance skin imaging at 1.5 T and 3 T

Barral

Bangerter

et al. 2010

Magn. Reson. Med.

View full text Add to dashboard Cite

1As a noninvasive modality, MR is attractive for in vivo skin imaging. Its unique soft tissue contrast makes it an ideal imaging modality to study the skin water content and to resolve the different skin layers. In this work, the challenges of in vivo high-resolution skin imaging are addressed. Three 3D Cartesian sequences are customized to achieve high-resolution imaging and their respective performance is evaluated. The balanced steady-state free precession (bSSFP) and gradient echo (GRE) sequences are fast but can be sensitive to off-resonance artifacts. The fast large-angle spin echo (FLASE) sequence provides a sharp depiction of the hypodermis structures but results in more specific absorption rate (SAR). The effect of increasing the field strength is assessed. As compared to 1.5 T, signalto-noise ratio at 3 T slightly increases in the hypodermis and almost doubles in the dermis. The need for fat/water separation is acknowledged and a solution using an interleaved three-point Dixon method and an iterative reconstruction is shown to be effective. The effects of motion are analyzed and two techniques to prevent motion and correct for it are evaluated. Images with 117 × 117 × 500 µm 3 resolution are obtained in imaging times under 6 min. Magn Reson Med 63:790-796, 2010.

show abstract

“…Epidermis (white arrow), dermis (white curly bracket), hypodermis (black curly bracket), an interlobular septum (black arrow) and a septal vessel (white arrowhead) are visible. Reprinted with permission 22 …”

Section: Clinical and Experimental Applications Of Mri In Skin Analysismentioning

confidence: 99%

“…Superficial (white arrow) and deep dermis (white arrowhead) are well distinguished. Reprinted with permission 22 …”

Section: Clinical and Experimental Applications Of Mri In Skin Analysismentioning

confidence: 99%

Magnetic resonance imaging of the skin

Stefanowska

Żakowiecki

Cal

2010

Acad Dermatol Venereol

View full text Add to dashboard Cite

A thorough examination of the skin is essential to screen various diseases accurately, evaluate the effectiveness of topically applied drugs and assess the results of dermatological surgeries such as skin grafts. The assessment of skin properties is also crucial in the cosmetics industry, where it is important to evaluate the effects skin care products have on these properties. The simplest and most widely used method of skin evaluation, the 'naked eye' assessment, enables researchers to assess only the skin surface and involves a large amount of inter-observer variability. Thanks to a great progress that has been made in physics, electronics and computer engineering in recent years, sophisticated imaging methods are increasingly available in day-to-day studies. The aim of this review was to present one of these techniques, namely the magnetic resonance imaging (MRI), and to discuss its possible use in skin examination and analysis. We present basic principles of MRI, as well as several interesting applications in the field of dermatology, and discuss the advantages and limitations of this method.

show abstract

Feasibility study of 3-T MR imaging of the skin

Cited by 25 publications

References 20 publications

In vivo assessment of aged human skin with a unilateral NMR scanner

In vivo assessment of aged human skin with a unilateral NMR scanner

In vivo high-resolution magnetic resonance skin imaging at 1.5 T and 3 T

Magnetic resonance imaging of the skin

Contact Info

Product

Resources

About