2015
DOI: 10.2334/josnusd.57.55
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Feasibility study of a salivary occult blood test to correlate with periodontal measures as indicators of periodontal inflammation in a population of pregnant women

Abstract: The purpose of this feasibility study was to investigate the correlation of a salivary occult blood test (SOBT) with traditional periodontal measures to assess the feasibility of the SOBT as a measure of periodontal inflammation in a population of women during pregnancy. Recognizing previous SOBT studies’ limitations, this study evaluated correlation of the Perioscreen® Sunstar SOBT with traditional measures from a full mouth periodontal examination. Data were collected at 3 times during pregnancy (12–14, 24–2… Show more

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Cited by 11 publications
(11 citation statements)
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“…Thus, various substances in GCF have been suggested as useful biomarkers for detecting periodontitis such as: host-derived enzymes and their inhibitors, inflammatory mediators and host-response modifiers, and byproducts of tissue breakdown [31]. However, most of them have not seen clinical application except for a few systems such as aspartate aminotransferase enzyme kit (Periogard) [32], neutral proteases detection kit (Periocheck) [33], and occult blood test paper (Perioscreen) [10][11][12].…”
Section: Discussionmentioning
confidence: 99%
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“…Thus, various substances in GCF have been suggested as useful biomarkers for detecting periodontitis such as: host-derived enzymes and their inhibitors, inflammatory mediators and host-response modifiers, and byproducts of tissue breakdown [31]. However, most of them have not seen clinical application except for a few systems such as aspartate aminotransferase enzyme kit (Periogard) [32], neutral proteases detection kit (Periocheck) [33], and occult blood test paper (Perioscreen) [10][11][12].…”
Section: Discussionmentioning
confidence: 99%
“…With a positive specimen, the conjugate bound to the anti-human hemoglobin antibody as a captured regent on the test band area and produced a red-violet colored band (positive line). Absence of a colored test band indicated a negative result [10][11][12]. After 5 min of reaction, visual evalu-ation of the test paper was distinguished as positive (++++, +++, ++, +) or negative (±, −) by 3 blinded examiners (AA, SK, and SM).…”
Section: Hb Detection By Immunochromatographic Paper Test Stripmentioning
confidence: 99%
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“…However, in terms of predicting the prevalence of periodontal disease, the cut-off points of 1.0 and 2.0 μg/mL need to be supported by more evidence before adoption. Furthermore, various other techniques have been reported to be more sensitive in the detection of haemoglobin in saliva, 21,45 including a commercially available kit that has been developed as a screening tool for the determination of periodontal status that correlates well to bleeding on probing. 45 Although our results and that of others [20][21][22][23]45 suggest that salivary haemoglobin testing may be appropriate for periodontal disease screening, further research is necessary in this area to determine appropriate cut-off points and protocols.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, we investigated hemoglobin positivity using a salivary occult blood test (SOBT) to screen for periodontal disease. An SOBT using monoclonal antibody against human hemoglobin has been used in investigating periodontal health, and it may be useful as a screening method for periodontal disease [7, 8]. An SOBT using anti-human hemoglobin monoclonal antibody has been used to reliably assess periodontal inflammation in pregnant women [7].…”
Section: Introductionmentioning
confidence: 99%