A new concept to concentrate seawater up to 200 g/kg for producing vacuum salt using a reverse osmosis (RO) system hybridized with an electrodialysis (ED) system is presented. The RO system operates up to pressures of 120 bar and concentrates seawater up to 120 g/kg with the ED system concentrating RO brine to 200 g/kg. A parametric analysis to minimize the specific cost of brine concentration was conducted. Parameters varied were: the degree of RO-ED hybridization, ED current density, electricity prices and water prices. Optimal hybrid RO-ED designs reduced brine concentration costs by 33-70 % over standalone ED systems, with revenue generated from water co-production further subsidizing costs by 1-6 %. Optimizing ED current density reduced costs the most. Including a crystallizer, the total reduction in production cost over a standalone ED-crystallizer system was 19-55 %, with the production cost for a typical case being $111/tonne-salt. The proposed RO-ED-crystallizer (REC) systems were found to be techno-economically feasible in Cyprus, Japan, Kuwait, Saudi Arabia, and the USA. At a road transportation distance of 735 km, REC based seawater vacuum salt was competitive with conventional vacuum salt. REC systems may open up the potential of small-scale decentralized salt production.