Feasibility study of hydrophilic and hydrophobic silica aerogels as drug delivery systems

Смирнова, Ирина; Suttiruengwong, Supakij; Arlt, Wolfgang

doi:10.1016/j.jnoncrysol.2004.06.031

Cited by 284 publications

(129 citation statements)

References 11 publications

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“…For the ibuprofen@H3 system 287 studied in this work, the release of 80 % was attained after 10 min in neutral pH and retarded to more than 300 min at acid pH. For the ketoprofen@silica 288 aerogel system, it has been shown that 60 min are necessary to release 80 % of the drug at acid pH (Smirnova et al 2004), similar to the value found in this 289 work for the ketoprofen@H3 system. For the TRF@silica aerogel system, previous studies showed that 80 % of the drug was released after 20 min in both 290 acid and basic pH (Murillo-Cremaes et al 2013).…”

Section: Drug Dissolution and Release Profiles 252supporting

confidence: 79%

“…Moreover, matrix systems with a more retarded profile can be used to maintain the therapeutic 64 dosage for a long period of time, thus, reducing the necessity of frequent dosage and increasing patient compliance. 65 Due to the highly porous structure of hybrid aerogels, they have been proposed as carrier matrixes for the molecular dispersion of poorly water-66 soluble drugs (Smirnova et al, 2004; Ulker and Erkey, 2014, García-González et al, 2011; Alnaief and Smirnova, 2010). In this study, drugs chosen for 67 analysis are class II weak acids, namely ibuprofen (Ibu), ketoprofen (Ket), and triflusal (Trf).…”

Section: Introduction 28mentioning

confidence: 99%

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Hybrid aerogel preparations as drug delivery matrices for low water-solubility drugs

Veres

López‐Periago

Lázár

et al. 2015

International Journal of Pharmaceutics

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Section: Drug Dissolution and Release Profiles 252supporting

confidence: 79%

Section: Introduction 28mentioning

confidence: 99%

Hybrid aerogel preparations as drug delivery matrices for low water-solubility drugs

Veres

López‐Periago

Lázár

et al. 2015

International Journal of Pharmaceutics

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“…These properties allow them to be used as a host matrix for drug delivery. Silica aerogels were recently shown to be a potential candidate for oral drug delivery systems [11][12][13]. A promising method to adsorb a drug into porous substrates is supercritical (SC) deposition or adsorption [11,12,[14][15][16].…”

Section: Introductionmentioning

confidence: 99%

Supercritical Fluid Adsorption of Domperidone on Silica Aerogel

Caputo¹

2013

ACES

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Silica aerogel (SA) was loaded with domperidone to demonstrate the potentiality of adsorption processes based on the usage of supercritical carbon dioxide to treat poorly water-soluble drugs, forming new kinds of drug delivery systems. The effects of pressure, temperature and solution concentration on loaded SA were studied. Adsorption isotherms were measured at 35˚C and 45˚C and fitted with Langmuir model. Release kinetics of the adsorbed drug were also evaluated by in vitro dissolution tests. Results showed that domperidone can be uniformly dispersed into the aerogel and that the release rate of domperidone from the composite, constituted by drug and silica aerogel, is much faster than that of the crystalline drug. The proposed adsorption method is suitable for the production of domperidone fast release tablets.

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“…Gelation is followed by the drying of the wet gel in an autoclave under supercritical conditions for CO 2 , a process that leads to a pure, homogeneous product with low density, high specific surface area, and high porosity [7,8]. This potentially allows them to be used in numerous applications, such as catalysis, fuel storage tanks, low dielectric constant materials, and fine particle collection [9,10].…”

Section: Introductionmentioning

confidence: 99%

Tuned optical transmittance in single-step-derived silica aerogels through pH-controlled microstructure

et al. 2017

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We have systematically studied the relationship between synthesis pH and morphological and optical properties of silica aerogels. We have determined through SEM and BET that there is a systematic correlation between the pH of the initial silica solution and the surface area, porosity, and pore size of the resulting aerogel. We find that optical transmittance, particularly its wavelength dependence (dispersion), is strongly governed by the microstructure and, therefore, synthesis pH. We have determined that the microstructure of the aerogels fall into three broad categories: monostructural, which is characterized by repeating elongated microstructural features; fractal, which shows a distinctive structure that is emulated on multiple length scales; and isotropic, which is characterized by having no distinct features in its microstructure. Simply by controlling the pH of the synthesis environment, we can tune the optical properties of silica aerogels through pH controlled the microstructural modification. We have found that pH = 1-5 gives high dispersion, pH = 6-7 results in low transmittance and low dispersion, pH = 8 shows the highest transmittance with the lowest dispersion, and pH = 9-10 transitions back to lower transmittance and higher dispersion.

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Feasibility study of hydrophilic and hydrophobic silica aerogels as drug delivery systems

Cited by 284 publications

References 11 publications

Hybrid aerogel preparations as drug delivery matrices for low water-solubility drugs

Hybrid aerogel preparations as drug delivery matrices for low water-solubility drugs

Supercritical Fluid Adsorption of Domperidone on Silica Aerogel

Tuned optical transmittance in single-step-derived silica aerogels through pH-controlled microstructure

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