Feasibility study of oral cyclophosphamide salvage therapy for the treatment of heavily pretreated patients with recurrent epithelial ovarian cancer

Watanabe, Yoh; Etoh, Tomomaro; Koike, Eiji; Mizuno, Y; Wang, Weimin; Hoshiai, Hiroshi

doi:10.1007/s10147-010-0094-1

Cited by 21 publications

(19 citation statements)

References 20 publications

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“…Watanabe et al 21 conducted a feasibility study of 14 heavily pretreated patients with ovarian cancer, using oral cyclophosphamide 50 mg b.i.d. for 21 days every 28 days.…”

Section: Discussionmentioning

confidence: 99%

Oral cyclophosphamide in recurrent ovarian cancer

Handolias

Quinn

Foo

et al. 2013

Asia-Pac J Clncl Oncology

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“…Watanabe et al 21 conducted a feasibility study of 14 heavily pretreated patients with ovarian cancer, using oral cyclophosphamide 50 mg b.i.d. for 21 days every 28 days.…”

Section: Discussionmentioning

confidence: 99%

Oral cyclophosphamide in recurrent ovarian cancer

Handolias

Quinn

Foo

et al. 2013

Asia-Pac J Clncl Oncology

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“…[22][23][24][25] Although Cy is a widely used antineoplastic agent, its cytotoxicity is not limited to tumor tissue.…”

Section: Discussionmentioning

confidence: 99%

Dietary squid ink polysaccharide could enhance SIgA secretion in chemotherapeutic mice

et al. 2014

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Secretory immunoglobulin A (SIgA) is a non-inflammatory antibody that shields internal body surfaces, such as in the intestine to neutralize pathogens in the lumen of the intestine. As chemotherapy seriously damages the mucosal immune system, we herein demonstrated that polysaccharide from the squid ink of Ommastrephes bartrami (OBP) activated intestinal SIgA secretion to prevent chemotherapeutic injury. Using a mouse model of chemotherapy induced intestinal injury by intraperitoneal injection of 50 mg kg(-1) cyclophosphamide, our results showed an enhanced SIgA concentration in intestinal mucosa by OBP administration and the higher production of SIgA relied on the greater expression of IgA, J chain and pIgR. Furthermore, the higher expressions of IL-6, IL-10 and TNF-α increased by OBP treatment contributed to enhanced IgA and J chain synthesis in IgA(+) plasma cells, and pIgR expression in epithelial cells. It also triggered a prompt immunoglobulin secretory pathway confirmed by enhanced UPR (unfolded protein response) effectors XBP-1s and Bip expression. Our results have important implications for the mucosal immunity enhancement effects of OBP as a functional food component for chemotherapeutic patients.

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“…Cy is one of the most common agents in the treatment of cancer [23] [24]. It has higher lethality towards rapidly proliferating cells, and this is not limited to tumor tissue.…”

Section: Discussionmentioning

confidence: 99%

The Preventative Effect of Dietary <i>Apostichopus japonicus</i> on Intestinal Microflora Dysregulation in Immunosuppressive Mice Induced by Cyclophosphamide

Shi¹,

Zheng²,

Wu³

et al. 2016

JBM

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Sea cucumbers are recognized as food and drug resources with many nutritional benefits, and Apostichopus japonicus is a kind of sea cucumber with good quality.Processing methods have some effect on its quality. This study aimed to explore the effects of Apostichopus japonicus with three different processing methods (dried, instant, and enzymatic sea cucummbers) on intestinal microflora dysregulation using a cyclophosphamide (cy) induced immunosuppressive mouse model. The expression of lysozyme, immunoglobulin A (IgA), and polymeric immunoglobulin receptor (pIgR) in the intestine and gut microbiota were investigated. The results showed that three types of A. japonicus could improve mucosal immunity and regulate gut microbiota. Dietary A. japonicus could reverse microbial imbalance, including increasing the bacterial diversity, enhancing the number of Bifidobacterium, and changing the bacterial composition. The most effect was observed with dried A. japonicus. Expression of lysozyme and IgA in the intestine was significantly increased. This study identified positive effects of dietary A. japonicus on mucosal immunity, particularly on gut microbiota, suggesting that dietary A. japonicus may aid in improving mucosal immunity and preventing exogenous infection. Additionally, the processing method has some effect on immunomodulatory function.

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Feasibility study of oral cyclophosphamide salvage therapy for the treatment of heavily pretreated patients with recurrent epithelial ovarian cancer

Abstract: Although moderate gastrointestinal toxicity was observed, oral CPA therapy contributed to improving the survival of heavily pretreated patients with recurrent epithelial ovarian cancer. A well-designed phase II trial in this regard is awaited.

Cited by 21 publications

References 20 publications

Oral cyclophosphamide in recurrent ovarian cancer

Oral cyclophosphamide in recurrent ovarian cancer

Dietary squid ink polysaccharide could enhance SIgA secretion in chemotherapeutic mice

The Preventative Effect of Dietary <i>Apostichopus japonicus</i> on Intestinal Microflora Dysregulation in Immunosuppressive Mice Induced by Cyclophosphamide

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Feasibility study of oral cyclophosphamide salvage therapy for the treatment of heavily pretreated patients with recurrent epithelial ovarian cancer

Abstract: Although moderate gastrointestinal toxicity was observed, oral CPA therapy contributed to improving the survival of heavily pretreated patients with recurrent epithelial ovarian cancer. A well-designed phase II trial in this regard is awaited.

Cited by 21 publications

References 20 publications

Oral cyclophosphamide in recurrent ovarian cancer

Oral cyclophosphamide in recurrent ovarian cancer

Dietary squid ink polysaccharide could enhance SIgA secretion in chemotherapeutic mice

The Preventative Effect of Dietary &lt;i&gt;Apostichopus japonicus&lt;/i&gt; on Intestinal Microflora Dysregulation in Immunosuppressive Mice Induced by Cyclophosphamide

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The Preventative Effect of Dietary <i>Apostichopus japonicus</i> on Intestinal Microflora Dysregulation in Immunosuppressive Mice Induced by Cyclophosphamide