The main load-bearing structure of submarines is the pressure shell. Shell failures are usually caused by high hydrostatic pressure and its own potential geometric imperfections. This paper proposes a cylindrical shell with a strong corrugated stiffening structure. Two theoretically geometrically identical shells are fabricated using CNC machining to ensure the reproducibility and reasonableness of the results. Firstly, the point cloud data of all the geometric parameters of the corrugated pressure cylindrical shells were obtained using a 3D scanner. Geomagic Control X 3D inspection software was used to determine the geometric deviations of the shells. Geometric reconstruction was performed using Geomagic Design X reverse modeling software to capture potential imperfections of the shells. The aluminum shells were then welded and placed in the pressure chamber. Failure loads were obtained for all shells by constant water injection and pressurization. Considering the confined nature of the pressure chamber, a nonlinear finite element analysis of the corrugated pressure cylindrical shell was carried out using Abaqus/Riks, taking into account actual fabrication imperfections. Finally, the failure behavior of the shells under uniform external pressure was determined. The results show that both corrugated pressure cylindrical shells have high machining accuracy. The numerical simulation results of the critical buckling load of the corrugated pressure cylindrical shells were in good agreement with the test results. The corrugated structure has additional advantages in retarding the generation and expansion of shell surface defects. The equilibrium path of the corrugated pressure cylindrical shell can be maintained in a smooth and continuous state, showing stable buckling behavior. This study will provide new inspiration for the structural design and failure prediction of the submarine pressure shell.