Feasibility study of silica sol as the carrier of a hydrophobic drug in aqueous solution using enrofloxacin as the model

Song, Meirong; Song, Jun‐Ling; Ning, Aimin; Bao-an, Cui; Cui, Shumin; Y, Zhou; An, Wan‐Kai; Dong, Xuesong; Zhang, Gege

doi:10.1016/j.msec.2009.08.008

Cited by 11 publications

(3 citation statements)

References 23 publications

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“…For free BZ3, n = 1.06 (R 2 = 0.98), which clearly shows a departure from both Fickian and non-Fickian mechanisms, probably due to the diffusion of the free BZ3 through the dialysis membrane. The release kinetics of all samples are also in agreement with a first order exponential decay (R 2 $ 0.99), which is a model commonly used to explain a release controlled by diffusion as well [35].…”

Section: In Vitro Release Of Benzophenone-3supporting

confidence: 73%

“…For spherical particles, n varies from 0.43 (Fickian model) to 0.85 (non-Fickian model), whereas a value of n = 1 describes a case-II release (diffusion through a plane sheet) [32,33]. Other mathematical models commonly encountered are zero-order, first order, as well as Higuchi [34,35]. All of them were tested in our samples and Table 6 presents the most meaningful fits with the associated correlation coefficients.…”

Section: In Vitro Release Of Benzophenone-3mentioning

confidence: 99%

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Retinyl palmitate polymeric nanocapsules as carriers of bioactives

Teixeira

Dreiss

Lawrence

et al. 2012

Journal of Colloid and Interface Science

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Nanocapsules containing poly(d,l-lactide) shell and retinyl palmitate core have been prepared by the pre-formed polymer interfacial deposition method. Dynamic light scattering measurements yielded an average hydrodynamic diameter of ∼220nm and a polydispersity index of ∼0.12. Small-angle neutron scattering experiments revealed the presence of two populations of nanocapsules of core diameters ∼192 and 65nm. Freeze fracture transmission electron microscopy showed a polydisperse population of nanocapsules (NC), with a poly(d,l-lactide) shell thickness between 11 and 3nm. For comparison purposes, nanoemulsions (NE, no polymer) and nanospheres (NS, polymer matrix) were also prepared. Each type of nanoparticles exhibited a different morphology (when examined by electron microscopy), in particular NC showed deformability by capillary adhesion. All three types of nanoparticles successfully encapsulated the poorly water-soluble molecules baicalein and benzophenone-3. The thermal behavior of the various nanoparticles was different to a physical mixture of its individual components. Cytotoxicity and phototoxicity assays, performed in human keratinocytes (HaCaT) and murine fibroblasts (BALB/c 3T3), showed that the NC were only cytotoxic at high concentrations. In vitro release studies of benzophenone-3, by the dialysis bag method using NC and NS, showed a sustained release; however, permeation studies using plastic surgery human abdominal skin in Franz diffusion cells showed that a higher amount of benzophenone-3 from NC penetrated into the skin, most probably due to the deformable nature of these nanoparticles.

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Section: In Vitro Release Of Benzophenone-3supporting

confidence: 73%

Section: In Vitro Release Of Benzophenone-3mentioning

confidence: 99%

Retinyl palmitate polymeric nanocapsules as carriers of bioactives

Teixeira

Dreiss

Lawrence

et al. 2012

Journal of Colloid and Interface Science

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“…Silica vehicles offer a number of advantages over organic polymers as silica is highly inert and stable, hydrophilic and therefore easy to disperse in aqueous media and suitable for many water insoluble therapeutic agents [27,28]. Unlike organic polymers, silica is not subjected to microbial attack and there is no porosity change occurring in these particles with media variations.…”

Section: Introductionmentioning

confidence: 99%

Recent Patents on the Synthesis and Application of Silica Nanoparticles for Drug Delivery

Foglia¹,

Álvarez²,

Catalano³

et al. 2011

BIOT

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Drug delivery systems are designed to improve therapy efficacy as well as patient compliance. This could be accomplished by specifically targeting a medication intact to its active site, therefore reducing side-effects and enabling high local drug concentrations. Silica nanoparticles have gained ground in the biomedical field for their biocompatibility and biodegradability, being themselves inert and stable, thus enabling a variety of formulation designs for application in the pharmaceutical industry. This paper is a review of the recent patents on the applications of silica nanoparticles for drug delivery and their preparation. The review will focus on the different techniques available to obtain silica nanoparticles with variable morphology and their drug targeting applications, providing an overview of silica particles synthesis described in the literature.

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Development of Novel Biodegradable Enrofloxacin–Silica Composite for In Vitro Drug Release Kinetic Studies

Ebadi

Rafati

2018

J Polym Environ

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Feasibility study of silica sol as the carrier of a hydrophobic drug in aqueous solution using enrofloxacin as the model

Cited by 11 publications

References 23 publications

Retinyl palmitate polymeric nanocapsules as carriers of bioactives

Retinyl palmitate polymeric nanocapsules as carriers of bioactives

Recent Patents on the Synthesis and Application of Silica Nanoparticles for Drug Delivery

Development of Novel Biodegradable Enrofloxacin–Silica Composite for In Vitro Drug Release Kinetic Studies

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