Feasibility study on equine acellular pericardium matrix (APM): A new tool for breast reconstruction

Berna, Giorgio; Cagli, Barbara; Persichetti, Paolo; Cogliandro, Annalisa; Silan, Francesco; Maritan, Monia; Dell’Antonia, Francesco

doi:10.1016/j.bjps.2020.05.013

Cited by 3 publications

(19 citation statements)

References 23 publications

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“…Chest wall defects are frequently caused by tumor herniation and resection (1,2,21,29,30,(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91). Defects in the chest wall impair the strong framework that supports breathing and safeguards the viscera (92).…”

Section: Chestmentioning

confidence: 99%

“…Consequently, it is essential to repair the chest wall properly (50). The material typically employed in chest wall repair is synthetic mesh (1,2,21,29,30,(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91). It does, however, have drawbacks (for example, infection) (93).…”

Section: Chestmentioning

confidence: 99%

“…It does, however, have drawbacks (for example, infection) (93). ADM has so been the subject of investigations to replace the mesh in these operations (Figure 1D) (1,2,21,29,30,33,36,68,(81)(82)(83)(84)(85)(86)(87)(88)(89)(90)(91)(94)(95)(96)(97)(98)(99)(100)(101).…”

Section: Chestmentioning

confidence: 99%

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Acellular dermal matrix in reconstructive surgery: Applications, benefits, and cost

Mohammadyari

Parvin²,

Khorvash³

et al. 2023

Front. Transplant.

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Modern tissue engineering has made substantial advancements that have revolutionized plastic surgery. Acellular dermal matrix (ADM) is an example that has gained considerable attention recently. ADM can be made from humans, bovines, or porcine tissues. ADM acts as a scaffold that incorporates into the recipient tissue. It is gradually infiltrated by fibroblasts and vascularized. Fortunately, many techniques have been used to remove cellular and antigenic components from ADM to minimize immune system rejection. ADM is made of collagen, fibronectin, elastin, laminin, glycosaminoglycans, and hyaluronic acid. It is used in critical wounds (e.g., diabetic wounds) to protect soft tissue and accelerate wound healing. It is also used in implant-based breast reconstruction surgery to improve aesthetic outcomes and reduce capsule contracture risk. ADM has also gained attention in abdominal and chest wall defects. Some studies have shown that ADM is associated with less erosion and infection in abdominal hernias than synthetic meshes. However, its higher cost prevents it from being commonly used in hernia repair. Also, using ADM in tendon repair (e.g., Achilles tendon) has been associated with increased stability and reduced rejection rate. Despite its advantages, ADM might result in complications such as hematoma, seroma, necrosis, and infection. Moreover, ADM is expensive, making it an unsuitable option for many patients. Finally, the literature on ADM is insufficient, and more research on the results of ADM usage in surgeries is needed. This article aims to review the literature regarding the application, Benefits, and costs of ADM in reconstructive surgery.

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Section: Chestmentioning

confidence: 99%

Section: Chestmentioning

confidence: 99%

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Acellular dermal matrix in reconstructive surgery: Applications, benefits, and cost

Mohammadyari

Parvin²,

Khorvash³

et al. 2023

Front. Transplant.

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“…that are involved in the regulation of cell adhesion, migration, proliferation and differentiation to guide the repairing process and functional reconstruction of defective, diseased or traumatized tissues and organs 1–6 . As a class of regenerative biomaterials, regenerative bio‐scaffolds have been increasingly used in a wide range of clinical applications, including dermal replacement, 1 vascular surgery, 2,3 abdominal wall reconstruction 7 and hernia repair, 8,9 breast reconstruction, 10 and myocardial repair 11 …”

Section: Introductionmentioning

confidence: 99%

“…reconstruction of defective, diseased or traumatized tissues and organs. [1][2][3][4][5][6] As a class of regenerative biomaterials, regenerative bioscaffolds have been increasingly used in a wide range of clinical applications, including dermal replacement, 1 vascular surgery, 2,3 abdominal wall reconstruction 7 and hernia repair, 8,9 breast reconstruction, 10 and myocardial repair. 11 However, the identification and quantification of various bioactive and functional peptide molecules are still challenging for process optimization, product characterization, and rational design of better bio-scaffolds.…”

mentioning

confidence: 99%

Complete proteomic profiling of regenerative bio‐scaffolds with a two‐step trypsinization method

2022

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Regenerative bio-scaffolds, widely used for clinical tissue reconstruction and tissue repairs, are functionally diversified and structurally complex decellularized tissue materials (e.g., extracellular matrix, ECM). ECM is naturally cross-linked and can be further selectively cross-linked upon processing. Identification, quantification and bioinformatics functional comparison of all ECM proteins are challenging for regenerative bio-scaffolds. In this study, we have applied proteomic profiling with a two-step sequential trypsinization method, and identified and quantified 300-400 constituent proteins in three commercially available regenerative bio-scaffolds (BioDesign Surgisis, ReGen tissue matrix, and ThormalGEN mesh). These proteins were classified into four categories and 14 subcategories based on their mainly biological function. The main components of regenerative bio-scaffolds were highly abundant ECM structural proteins, and the minor parts of bio-scaffolds were lowly abundant, less cross-linked, functionally more diversified proteins, especially extracellular fluid proteins that were easily solubilized by trypsin. The comparative analysis has revealed large differences in the number, type, abundance and function of identified proteins, as well as the extent of decellularization and cross-linking among regenerative bio-scaffolds. So, the proteomic profiling with a two-step sequential trypsinization method could not only provide the molecular basis to better understand the degradation process of regenerative bio-scaffolds in vivo and different clinical outcomes among various regenerative bio-scaffolds, facilitate the exploration of the response mechanisms in the host's early clinical stages of ECM-induced tissue regeneration that is still poorly understood, but also can be used for optimization of the decellularization and crosslinking process, product characterization and rational design of new ECM products.decellularization, extracellular matrix protein, proteomic analysis, regenerative bio-scaffold | INTRODUCTIONRegenerative bio-scaffolds, now widely used for human soft tissue repair and regeneration, are the acellular extracellular matrices (ECM) of allogeneic and xenogeneic tissues or organs. These bio-scaffolds are naturally cross-linked, and can be further selectively cross-linked during processing to reduce immunogenicity, enhance stability and improve mechanical strength. The functionally diversified and structurally complex ECM protein networks in regenerative bio-scaffolds not only have excellent structural properties, but also contain many bio-active substances (such as collagen, elastin, proteoglycan, fibronectin, laminin, and a variety of cell growth factors, cytokines, etc.) that are involved in the regulation of cell adhesion, migration, proliferation and differentiation to guide the repairing process and functional

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A High-biocompatibility Interface for the Breast Implant: First Report of a Novel Biological Matrix–assisted Technique in Aesthetic Revision Surgery

Muccioli Casadei,

Corezzola,

Monticelli

2024

Plastic and Reconstructive Surgery - Global Open

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Summary: Development of human-compatible tissues is an active field of research that is leading to the production of optimized biological scaffolds to support regenerative medicine. Xenogenic acellular matrices are known to have strongly influenced the field of breast surgery, playing an integral role in wound healing and in preventing the foreign body reaction to silicone implants. Here, we present our experience in using a biological matrix for aesthetic revision surgery with malposition and severe capsular contracture. Revisions were performed using the new MASQUE equine acellular-pericardium-matrix (APM) as an anterior cover for the synthetic prosthesis. Acting as an internal support, the thin APM layer provides a biological and biocompatible interface between the synthetic implant and living tissues, exerting a protective function against fibrotic responses and capsular contracture. The role of an APM in matrix-assisted mammoplasty has yet to be fully established. Our early experience of APM-assisted aesthetic revision surgery shows promising results, laying the foundations for equine biological matrices as a valid tool for the management of capsular contracture-susceptible patients.

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Feasibility study on equine acellular pericardium matrix (APM): A new tool for breast reconstruction

Cited by 3 publications

References 23 publications

Acellular dermal matrix in reconstructive surgery: Applications, benefits, and cost

Acellular dermal matrix in reconstructive surgery: Applications, benefits, and cost

Complete proteomic profiling of regenerative bio‐scaffolds with a two‐step trypsinization method

A High-biocompatibility Interface for the Breast Implant: First Report of a Novel Biological Matrix–assisted Technique in Aesthetic Revision Surgery

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