ABSTRACT:This paper investigates the adaptation of MFCCs to the diagnosis of Parkinson's disease (PD). The aim of this study is to provide a novel method, suitable for keeping track of the evolution of the patient's pathology: easy-to-use, fast, non-invasive for the patient, and affordable for the clinicians. This method will be complementary to the existing ones -the perceptual judgment and the usual objective measurement (jitter, airflows...) which remain time and human resource consuming. The system designed for this particular task relies on the Mel-Frequency Cepstral coefficients (MFCC) for feature extraction and Vector Quantization (VQ) for feature analysis which is the state-of-theart for speaker recognition.