IoT-based EHRs use machine learning technology to automate real-time patient-centered records more securely for authorized users. (1) Background: In this era of pandemics, predictive healthcare systems are necessary for private and public healthcare delivery to predict early cancer, COVID-19, hypertension, and fever in Educational Institutions and Elderly Homes. IoT-Based EHRs bring healthcare delivery to the doorsteps of educational home facilities users, thereby reducing the time required to access healthcare and minimizing direct physical interaction between individuals seeking healthcare and their providers. (2) Method: This research work proposed a real-time intelligent IoT-based EHR system that generates vital signs of students within the educational environment using contactless sensors (Raspberry Pi Noir Camera, rPPG camera) and contacted wearable sensors composed of enzymatic sensor, immunogens, and nanosensors to detect cancer (Leukaemia). AFTER CAPTURING THE PHYSIOLOGICAL DATA, THE in-build EWS plots system determines the condition and further triggers the criticality (abnormality) in health status. (3) Discussion: For effective health status prediction by the proposed plan, the vital sign dataset was used to train a model for the proposed method. Among the best-performing models, the random forest algorithm proved a better model, with an accuracy of 99.66% and an error rate of 0.34%. (4) Conclusion: The Home HMS seeks to improve health prediction in institutional homes for users' overall well-being.