Due to its good versatility and independence, intelligent optimization algorithm has largely shortened the time of decision-making in large-scale optimization problems of manufacture. However, lower searching time often conflicts with the searching accuracy in most cases. To improve the problem solving capability, research in intelligent optimization algorithm based on different domain characteristics never stopped. From the view of manufacturing, this chapter classified and comprehensively analyzed all kinds of manufacturing optimization problems and their general methods, illustrated the application features and challenges of intelligent optimization algorithm in manufacturing, and summarized the development needs and trends of intelligent optimization algorithm in the field of manufacturing system.