This paper proposes a gearbox fault diagnosis method with HMSDE, DANCo-DDMA and AOA-KELM. Firstly, the raw HMSDE features are extracted from the raw time domain signals, then, the intrinsic dimension of the HMSDE features is estimated by DANCo, and the extracted HMSDE features are dimensionality reduction by DDMA for eliminating the redundant information. Finally, AOA-KELM is used to classify the reduced HMSDE features. Two experiments are used for verifying the effectiveness and practicality of the proposed gearbox fault diagnosis method, and the results showed that the HMSDE feature has exhibited better characterization performance for the operating state and real behavior of the mechanical system compared with MMSDE, HSDE, and RCMSDE. The AOA-KELM classifier has reached 100% classification accuracy by inputting the reduced HMSDE features, and has achieved a maximum classification accuracy with a minimum fluctuation among LSSVM, RF, KNN, and SOF classifiers, indicating that the proposed method is effectively realized the gearbox fault diagnosis under different working conditions.