Feature information extraction from dynamic biospeckle

Zheng, Bin; Pleass, Charles M.; Ih, Charles S.

doi:10.1364/ao.33.000231

Cited by 28 publications

(2 citation statements)

References 7 publications

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“…The principle of phase contrast, discovered for visible light in the 1930s [13], had been successfully translated to the X-ray regime in 1965 [14], but received increased attention only with the advent of third-generation synchrotrons providing wider access to highly brilliant, coherent and monochromatic X-rays. Since then, X-ray phase-contrast imaging has seen numerous developments and found a large range of applications, e.g., for biomedical, for stress, strain and vibration measurements of rough surfaces [104][105][106][107][108] and dynamic speckle for the investigation of biological processes [109][110][111][112][113][114]. Even the use of laser speckle for eye testing has been demonstrated [115].…”

Section: Introductionmentioning

confidence: 99%

State of the Art of X-ray Speckle-Based Phase-Contrast and Dark-Field Imaging

Zdora

2018

J. Imaging

106

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Abstract:In the past few years, X-ray phase-contrast and dark-field imaging have evolved to be invaluable tools for non-destructive sample visualisation, delivering information inaccessible by conventional absorption imaging. X-ray phase-sensing techniques are furthermore increasingly used for at-wavelength metrology and optics characterisation. One of the latest additions to the group of differential phase-contrast methods is the X-ray speckle-based technique. It has drawn significant attention due to its simple and flexible experimental arrangement, cost-effectiveness and multimodal character, amongst others. Since its first demonstration at highly brilliant synchrotron sources, the method has seen rapid development, including the translation to polychromatic laboratory sources and extension to higher-energy X-rays. Recently, different advanced acquisition schemes have been proposed to tackle some of the main limitations of previous implementations. Current applications of the speckle-based method range from optics characterisation and wavefront measurement to biomedical imaging and materials science. This review provides an overview of the state of the art of the X-ray speckle-based technique. Its basic principles and different experimental implementations as well as the the latest advances and applications are illustrated. In the end, an outlook for anticipated future developments of this promising technique is given.

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Section: Introductionmentioning

confidence: 99%

State of the Art of X-ray Speckle-Based Phase-Contrast and Dark-Field Imaging

Zdora

2018

J. Imaging

106

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“…for laser-based displays [Chellappan et al, 2010;Kuratomi et al, 2010;Pan and Shih, 2014] and in coherent optical imaging [Liba et al, 2017;Schmitt et al, 1999]. On the other hand, it has found many applications such as speckle imaging in astronomy [Bates, 1982;Horch, 1995;Dainty, 1984b], electronic speckle pattern interferometry for stress, strain and vibration measurements of rough surfaces [Jones and Wykes, 1989;Høgmoen and Pedersen, 1977;Ennos, 1975;Sharp, 1989; and dynamic speckle for the investigation of biological processes Asakura, 1996, 1991;Fujii et al, 1985;Zheng et al, 1994;Rabal and Braga, 2008;Boas and Dunn, 2010]. Even the use of laser speckle for eye testing has been demonstrated [Mohon and Rodemann, 1973].…”

Section: Background and Introductionmentioning

confidence: 99%

X-ray Phase-Contrast Imaging Using Near-Field Speckles

Zdora¹

2021

Springer Theses

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In the last decades, X-ray phase-contrast imaging has proven to be a powerful method for unveiling the inner structure of samples and is capable of visualising even minute density differences. Recently, speckle-based imaging (SBI), the youngest X-ray phase-sensitive technique, has received great interest due to its high sensitivity, quantitative character and relaxed requirements on the setup components and beam properties. This thesis is focussed on the development, experimental optimisation and applications of SBI, with the aim of simplifying its implementation, increasing its flexibility and expanding its potential.For this, a robust, flexible data acquisition and reconstruction approach, the unified modulated pattern analysis (UMPA), was developed, which lifts previous constraints of SBI. UMPA allows for tuning of the sensitivity and spatial resolution by adjusting the scan and reconstruction parameters. It is applicable not only to random speckle, but also periodic interference patterns, bridging the gap and improving the performance of both speckle-and single-grating-based techniques.Following the first demonstration of UMPA, its potential for a range of applications is illustrated in this thesis. It is shown that UMPA can be employed for X-ray optics characterisation to quantify aberrations in the focussing behaviour of X-ray refractive lenses with high precision and accuracy. UMPA phase tomography is applied to the field of biomedical imaging for high-sensitivity three-dimensional (3D) virtual histology of unstained, hydrated soft tissue, giving unprecedented structural and quantitative density information.Further developments of SBI explored in this thesis include the testing of novel customisable speckle diffusers, the extension of SBI to higher X-ray energies for geology and materials science applications, and the demonstration of UMPA at a laboratory X-ray source. These progresses promise new possibilities of SBI for high-sensitivity, robust and high-throughput imaging in previously inaccessible fields and make SBI accessible to a wider range of users in research and industry.

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Speckle techniques

Briers¹

1997

Optical Measurement Methods in Biomechanics

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Feature information extraction from dynamic biospeckle

Cited by 28 publications

References 7 publications

State of the Art of X-ray Speckle-Based Phase-Contrast and Dark-Field Imaging

State of the Art of X-ray Speckle-Based Phase-Contrast and Dark-Field Imaging

X-ray Phase-Contrast Imaging Using Near-Field Speckles

Speckle techniques

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