-In this paper, we present the implementation of an integrated time-series data mining environment. Time-series data mining is one of key issues to get useful knowledge from data bases. To execute time-series data mining smoothly, we have designed an environment which integrates time-series pattern extraction methods, rule induction methods and rule evaluation methods with active human-system interaction. After implementing this environment, we have done a case study to mine time-series rules from blood/urine biochemical test data base on chronic hepatitis patients. Then a physician has evaluated and refined his hypothesis on this environment. We discuss the availability of how much support to mine interesting knowledge for an expert.