2024
DOI: 10.7554/elife.96719
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Feature sequence-based genome mining uncovers the hidden diversity of bacterial siderophore pathways

Shaohua Gu,
Yuanzhe Shao,
Karoline Rehm
et al.

Abstract: Microbial secondary metabolites are a rich source for pharmaceutical discoveries and play crucial ecological functions. While tools exist to identify secondary metabolite clusters in genomes, precise sequence-to-function mapping remains challenging because neither function nor substrate specificity of synthesis enzymes can accurately be predicted. Here we developed a knowledge-guided bioinformatic pipeline to solve these issues. We analyzed 1928 genomes of Pseudomonas bacteria and focused on iron-scavenging … Show more

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