Features and relationships of metabolic syndrome components in men with androgen deficiency. Part 2. Disorders of carbohydrate and purine metabolism. Retrospective study data

Abstract

Introduction. There are few epidemiological data on violations of purine and carbohydrate metabolism in association with testosterone deficiency in men with overweight due to adipose tissue and metabolic syndrome (MS).Aim: to study the relationships between disturbances in carbohydrate and purine metabolism and testosterone level in men with excess adipose tissue and MS.Materials and Мethods. There were enrolled 64 overweight men to the study. The patients were divided into 3 groups based on the body mass index (BMI): group 1 – with overweight (n = 24), group 2 – with the first degree of obesity (n = 21), group 3 – with the second and third degree of obesity (n = 19). A correlation analysis was carried out between the data of carbohydrate and purine metabolism in relation to testosterone level and body composition, as well as additionally assessing the level of inter-group difference.Results. The relationship between the parameters of carbohydrate and purine metabolism and the level of total testosterone has been identified, and it's formed against the background of overdeveloped adipose tissue. A weak negative correlation was found across the sample between testosterone and glucose, insulin, and the НОМА-IR (Homeostasis Model Assessment of Insulin Resistance) index. That is, the higher the level of glucose, the НОМА-IR index, the lower the testosterone level. In addition, it was noted that an increase in BMI caused higher insulin levels. The number of patients with fasting blood glucose levels above 5.6 mmol/L and insulin resistance also increased. In the group with I degree of obesity, a negative correlation was found between the levels of total testosterone and uric acid.Conclusion. Thus, the thesis is confirmed that the more significant the violation of carbohydrate and purine metabolism, the more significant androgenic deficiency. It is obvious that the most effective solution in choosing a strategy for treating androgen deficiency and disorders of carbohydrate and purine metabolism in overweight men is to normalize body composition and get rid of excess adipose tissue.