Features Associated with Recurrence Beyond 5 Years After Nephrectomy and Nephron-Sparing Surgery for Renal Cell Carcinoma: Development and Internal Validation of a Risk Model (PRELANE score) to Predict Late Recurrence Based on a Large Multicenter Database (CORONA/SATURN Project)

Surveillance Following Nephron-Sparing Surgery: An Assessment of Recurrence Patterns and Surveillance Costs

“…However, in the 29.7% of the entire cohort who had NSS, the recurrence rate was 3.4% compared to 7.9% in patients treated with radical nephrectomy (P <.001). 18 Therefore, it is possible that the rate of late recurrences in the patients with pT1a treated with NSS was lower than 2.6% reported for the entire pT1a cohort. It is conceivable that tumors selected for NSS may inherently have less aggressive biological features, which may make these lesions less susceptible to late relapse.…”

Post Partial Nephrectomy Surveillance Imaging: an Evidence-Based Approach

“…One study found that the development of late recurrence was associated with lymphovascular invasion, high Fuhrman grade (III-IV), and pathologic tumor stage >pT1 at primary diagnosis [34]. In a related report, Adamy et al [35] compared patients with late recurrence to those with early recurrence after nephrectomy.…”

Canadian Urological Association guideline for followup of patients after treatment of non-metastatic renal cell carcinoma

“…Most recurrences are distant rather than local. [82][83][84] The largest study evaluating relapse after 5 years following nephrectomy demonstrated lymphovascular invasion, Furhman grade 3 or 4, and pathologic tumour stage >pT1 as independent predictors of late recurrence. In addition, late recurrence was approximately 2.6%, 5%, 9%, 10%, 11% and 22% for T1a, T1b, T2a, T2b, T3a and T3b respectively.…”