Actuality. With the emergence and rapid spread of the new coronavirus SARS-CoV-2, unprecedented measures have been taken to combat the pandemic, which in many countries, including Ukraine, has led to severe restrictions with the transition of all levels to distance learning.The aim of the work is to study and compare the main indicators of social and psychological adaptation of domestic and foreign students to study under distance education during quarantine.Material and methods. The study of the main indicators of personal adaptation of 3rd-year students of medical faculties of BSMU during distance learning under quarantine conditions was conducted. The indicators were studied by surveying domestic and foreign students using Google Forms and Google Meet videoconferencing. The survey was conducted anonymously, under the same conditions, and to create a questionnaire in Google Forms used an adapted version of the questionnaire BOO "Adaptability" in Ukrainian and English, which is designed to assess the adaptive capacity of man. Results. According to the results of the survey, during distance learning, the level of neuropsychological stability of domestic students was probably higher than that of foreign citizens. Foreign students had a socialization rate 1.5 times lower than Ukrainian students did, and the vast majority of domestic students had a sufficient level of socialization. Communicative abilities of domestic students compared to foreign students were also significantly higher, but both Ukrainian and foreign students during quarantine and distance learning show almost no signs of behavioral disorders. In general, both domestic and foreign students during distance learning in quarantine have a low level of adaptation, and its success depends on external conditions (distance and isolation).Conclusion. Under the conditions of quarantine, students of medical faculties of BSMU, both domestic and foreign are characterized by a rather low level of socio-psychological adaptation to distance learning.