Features of aggressive breast cancer

Arpino, Grazia; Milano, Monica; Placido, Sabino De

doi:10.1016/j.breast.2015.06.001

Cited by 56 publications

(43 citation statements)

References 60 publications

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“…30 Several studies have reported that presence of genetic factors as mutations and polymorphisms (BRCA1/2, TP53, PTEN and MIF) plays an important role in the development of BC, as well as proinflammatory cytokines, like MIF. 25,31 The human MIF gene is characterized by the presence of a single nucleotide polymorphism (-173 G > C) and a microsatellite repeat (-794 CATT) both in the promoter region. 11 The involvement of MIF alleles in the development of cancer was first associated and described in prostate cancer.…”

Section: Discussionmentioning

confidence: 99%

Association of the genetic variants (‐794 CATT5‐8 and ‐173 G > C) of macrophage migration inhibitory factor (MIF) with higher soluble levels of MIF and TNFα in women with breast cancer

Avalos‐Navarro

Toro-Arreola

Daneri-Navarro

et al. 2020

Clinical Laboratory Analysis

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Background: Functional variants -173 G > C (rs755622) and -794CATT 5-8 (rs5844572) MIF gene have been associated with the risk in several types of cancer, as well as with the increase of soluble levels of MIF and TNFα. However, in previous studies contradictory and uncertain results have been presented on the implication of MIF polymorphisms with the association in cancer, specifically in breast cancer (BC). We investigated whether the variants are associated with the susceptibility to develop BC and the soluble levels of MIF and TNFα in women with BC from western Mexico. Materials and methods:A total of 152 women with BC and 182 control subjects (CS) were enrolled in this study. The determination of genotypes -173 G > C and -794 CATT 5-8 MIF polymorphisms was performed by PCR-RFLP and PCR, respectively. In addition, the soluble levels of MIF and TNFα in both studied groups were quantified by ELISA and MILLIPLEX assay, respectively. Results:The most frequent allele found in BC was the G (74.3%) and 6 (54%) in the variants -173G > C and -794 CATT 5-8 , respectively, without significant differences in both groups. Nevertheless, the women with BC carriers -173*C and -794CATT 7 have higher levels of MIF in comparison with CS. An increase of MIF (BC: 11.1 ng/mL vs CS: 5.2 ng/mL, P < .001) and TNFα (BC: 24.9 ng/mL vs CS: 9.9 pg/mL, P < .001) was found. Conclusion:The functional variants of MIF are not genetic susceptibility markers for BC. Nevertheless, the alleles -173*C and -794CATT 7 are associated with the increase of MIF circulating in women with BC.

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Section: Discussionmentioning

confidence: 99%

Association of the genetic variants (‐794 CATT5‐8 and ‐173 G > C) of macrophage migration inhibitory factor (MIF) with higher soluble levels of MIF and TNFα in women with breast cancer

Avalos‐Navarro

Toro-Arreola

Daneri-Navarro

et al. 2020

Clinical Laboratory Analysis

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“…The microarray analyses identified the triple-negative breast cancer (ER-, PR- and HER2-negative) as a clinically heterogeneous malignancy and the most aggressive BCa subtype that is characterised by high rates of tumour recurrence and poor overall survival. Aggressive phenotype of TNBC defined by poor disease-free survival, high recurrence rate and shortened time of overall survival is connected with biological and clinical factors, including high nuclear grade, high histological grade, high genomic instability, loss of suppressor genes, as well as gain of migratory, invasive and stem cell-like properties of cancer cells (Arpino et al 2015). …”

Section: Triple-negative Breast Cancer—molecular Featuresmentioning

confidence: 99%

MicroRNAs in regulation of triple-negative breast cancer progression

Piasecka

Braun

Kordek

et al. 2018

J Cancer Res Clin Oncol

147

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PurposeDysregulation of miRNA profile has been associated with a broad spectrum of cellular processes underlying progression of various human malignancies. Increasing evidence suggests that specific microRNA clusters might be of clinical utility, especially in triple-negative breast carcinoma (TNBC), devoid of both predictive markers and potential therapeutic targets. Here we provide a comprehensive review of the existing data on microRNAs in TNBC, their molecular targets, a putative role in invasive progression with a particular emphasis on the epithelial-to-mesenchymal transition (EMT) and acquisition of stem-cell properties (CSC), regarded both as prerequisites for metastasis, and significance for therapy.MethodsPubMed and Medline databases were systematically searched for the relevant literature. 121 articles have been selected and thoroughly analysed.ResultsSeveral miRNAs associated with EMT/CSC and invasion were identified as significantly (1) upregulated: miR-10b, miR-21, miR-29, miR-9, miR-221/222, miR-373 or (2) downregulated: miR-145, miR-199a-5p, miR-200 family, miR-203, miR-205 in TNBC. Dysregulation of miR-10b, miR-21, miR-29, miR-145, miR-200 family, miR-203, miR-221/222 was reported of prognostic value in TNBC patients.ConclusionAvailable data suggest that specific microRNA clusters might play an important role in biology of TNBC, understanding of which should assist disease prognostication and therapy.

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“…In a survey, an estimated 232,670 women were expected to be diagnosed with breast cancer, and 40,000 deaths expected in 2014 [5]. In Europe in 2012, an estimated 463,800 new breast cancer cases and breast cancer-related deaths of 131,200 were recorded [6]. …”

Section: Introductionmentioning

confidence: 99%

Higher serum concentrations of vimentin and DAKP1 are associated with aggressive breast tumour phenotypes in Ghanaian women

et al. 2017

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BackgroundBreast cancer, the most commonly diagnosed cancer among women and leading cause of cancer-related deaths worldwide, exhibits aggressive behavior in indigenous African women evidenced by high histologic grade tumours with low hormone receptor positivity. Aggressive breast cancers grow quickly, easily metastasize and recur and often have unfavourable outcomes. The current study investigated candidate genes that may regulate tumour aggression in Ghanaian women. We hypothesize that increased expression and function of certain genes other than the widely-held view attributing breast cancer aggression in African populations to their younger population age may be responsible for the aggressive nature of tumours.MethodsEmploying ELISA, we assayed for vimentin and death-associated protein kinase 1 (DAPK1) from thawed archived (stored at -80 °C) serum samples obtained from 40 clinically confirmed Ghanaian breast cancer patients and 40 apparently healthy controls. Patients’ clinical records and tumour parameters matching the samples were retrieved from the database of the hospital. ANOVA was used to compare means of serum protein concentration among groups while Chi-square analysis was used for the categorical data sets with p-value ≤0.05 considered significant. Multiple logistic regression analysis was conducted to determine the association between protein concentration and tumour parameters.ResultsOf the 80 samples, 27 (33.8%) and 53 (66.2%) were from young (<35 years) and old (≥35 years), respectively. Vimentin and DAPK1 concentration were higher in patients than controls with higher levels in “young” age group than “old” age group. Vimentin concentration was highest in grade 3 tumours followed by grade 2 and 1 but that for DAPK1 was not significant. For vimentin, tumour area strongly correlated with tumour grade (r = 0.696, p < 0.05) but weakly correlated with tumour stage (r = 0.420, p < 0.05). Patient’s age correlated with DAPK1 concentration (r = 0.393, p < 0.05). DAPK1 serum levels weakly correlated with cancer duration (r = 0.098, p = 0.27) and tumour size (r = 0.40, p < 0.05).ConclusionSerum concentration of Vimentin and DAPK1 are elevated in Ghanaian breast cancer patients. This may be partly responsible for aggressive nature of the disease among the population. Vimentin and DAPK1 should be explored further as potential breast cancer biomarkers in Africans.

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Features of aggressive breast cancer

Abstract: Identification of these factors and understanding their contribution to the aggressiveness of MBC and disease progression may lead to more personalized treatment in this patient population.

Cited by 56 publications

References 60 publications

Association of the genetic variants (‐794 CATT5‐8 and ‐173 G > C) of macrophage migration inhibitory factor (MIF) with higher soluble levels of MIF and TNFα in women with breast cancer

Association of the genetic variants (‐794 CATT5‐8 and ‐173 G > C) of macrophage migration inhibitory factor (MIF) with higher soluble levels of MIF and TNFα in women with breast cancer

MicroRNAs in regulation of triple-negative breast cancer progression

Higher serum concentrations of vimentin and DAKP1 are associated with aggressive breast tumour phenotypes in Ghanaian women

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