Features of Asymptomatic Hyperuricemia in Patients With Diabetes Mellitus Type 2 and Concomitant Essential Arterial Hypertension

Virstyuk, N. G.; Ikwuka, Aloysius Obinna

doi:10.24061/1727-4338.xvii.1.63.2018.5

Cited by 13 publications

(14 citation statements)

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“…Metabolic disorders e.g. Hypertension, Adiposity, Diabetes mellitus and Dyslipidemia collectively known as Metabolic Syndrome Diseases (MSDs) are diseases related to one another and have very high morbidity and mortality rates [15,16,18,33,35,52]. Results obtained from different researches have shown that hypertension, diabetes mellitus, adiposity and dyslipidemia, asymptomatic hyperuricemia, systemic immune inflammation activation and fibrogenesis, can lead to kidney damage [19,20,21,23,24,25,30,32,34,53,54,55,56,60], and can also affect the brain blood supply leading to neuronal damage.…”

Section: Discussionmentioning

confidence: 99%

“…Dapagliflozin and Glucagon-like Peptide 1 Receptor Agonists (GLP-1 RAs) e.g. Liraglutide have been found to improve the efficacy of treatment and clinical course of type 2 diabetes mellitus and hypertension in patients with such comorbidities [17,22,26,31,57,58,59]. It has also been documented that coconut water has hepatorenal protective functions in alloxaninduced type 1 diabetes mellitus [13].…”

Section: Discussionmentioning

confidence: 99%

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Optimization of Delirium Care in Adult Patients with Cancer: A Comprehensive and Integrative Review of Efficacy and Patient Outcomes

Ojiaku,

Duru,

Ikwuka

et al. 2024

WJCMR

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Delirium is a major complication most commonly observed in patients with advanced cancer. However, despite its prevalence, the early diagnosis, management, and prevention of this condition have not seen significant progress. Aim of this research is to provide insights into the prevalence of delirium, the optimization of interventions for managing delirium symptoms, their effectiveness and the impact of underlying factors on the reversibility of delirium in advanced cancer patients receiving palliative care. The review involved systematic searches of relevant databases including MEDLINE, CINAHL, ProQuest Nursing and Allied Health, and PsychInfo using refined search terms. Eight publications out of 614 studies originally searched were selected and critically reviewed. Their quality was assessed using Joanna Briggs Institute's Critical Appraisal Tool for Case Series. Data abstraction and content analysis were performed to synthesize the findings. Delirium is prevalent among advanced cancer patients in palliative care, with rates ranging from 10.3% to 24.1%. Pharmacotherapy and non-pharmacological interventions showed effectiveness in reducing delirium symptoms. Delirium was found to be reversible through palliative care interventions, antipsychotic medications, and exercise therapy. Effective delirium management is crucial in improving the quality of life of cancer patients. This review emphasizes the importance of subtype-specific treatments, standardized guidelines, and long-term follow-up studies. Implementing evidence-based individualized approaches to delirium management can optimize treatment efficacy and clinical outcomes in patients as well as improve the quality of care. Tailored interventions, standardized protocols, and further research are hereby recommended.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Optimization of Delirium Care in Adult Patients with Cancer: A Comprehensive and Integrative Review of Efficacy and Patient Outcomes

Ojiaku,

Duru,

Ikwuka

et al. 2024

WJCMR

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“…In addition, the interplay, role and effects of metabolic syndrome diseases on male fertility are still being investigated by different researchers (Baysah, 2023). Metabolic syndrome diseases, MSDs (Hypertension, Adiposity, Diabetes mellitus and Dyslipidemia) are interrelated diseases with very high morbidity and mortality rates (Ikwuka, 2015;Ikwuka, 2017a;Ikwuka, 2017c;Ikwuka, 2023c;Ikwuka, 2023f;Virstyuk, 2016). Results from different studies have shown that high levels of blood pressure, glucose and lipid metabolic disorders, asymptomatic hyperuricemia, activation of systemic immune inflammation and fibrogenesis, contribute to kidney damage (Ikwuka, 2017d;Ikwuka, 2017e;Ikwuka, 2018a;Ikwuka, 2018c;Ikwuka, 2018d;Ikwuka, 2019a;Ikwuka, 2019c;Ikwuka, 2022;Ikwuka, 2023d;Virstyuk, 2017a;Virstyuk, 2018a;Virstyuk, 2021a;Virstyuk, 2021b).…”

Section: Introductionmentioning

confidence: 99%

Sperm Parameters and Testicular Histology of Male Wistar Rats Treated with Phoenix Dactylifera after Consumption of Local Mmahi Salt

Ama,

Ikwuka,

Udeh

et al. 2023

Am. J. Biosci. Bioinform.

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Phoenix dactylifera (date fruit) is one of the nutritious and healthiest fruits due to its excellent nutritional properties, and many beneficial health and medicinal properties. The aim of this study was to evaluate sperm parameters and testicular histology of male Wistar rats treated with Phoenix dactylifera after consumption of a dose of local Mmahi salt (local salt of Ebonyi State origin, in Nigeria). Fresh date fruits, Mmahi salt, rat feed, clean drinking water, and 24 male wistar rats were the main materials for this study. The rats were divided into 6 groups: Group 1 (negative control group with 0% Mmahi salt (MS) and date fruit exposure), Group 2 (positive control I that received 75mg/kg of MS for 4 weeks), Group 3 (positive control II that received 75mg/kg of MS for 4 weeks followed by 2 weeks of self-recovery), Group 4 (that received 75mg/kg of MS for 4 weeks followed by 2 weeks of 200mg/kg of date fruit), Group 5 (that received 75mg/kg of MS for 4 weeks followed by 2 weeks of 400mg/kg of date fruit), and Group 6 (that received 75mg/kg of MS for 4 weeks followed by 2 weeks of 600mg/kg of date fruit). Actively motile spermatozoa in this study had mean±SEM in G1 (65.00±2.89), G2 (55.00±0.00), G3 (45.00±2.89), G4 (63.75±2.39), G5 (55.50±2.04), and G6 (58.75±2.39). Sluggishly motile spermatozoa were low in the groups treated with higher doses of date fruit extract, but least in G1. Non-motile spermatozoa were high in G2 and G3, but lower in G1, G5, and G6. G4, G5, and G6 had higher sperm counts compared to G2 and G3, although not significant. Histological examination showed in G1 - normal histology, in G2 - moderate spermatogenic arrest, in G3 - severe distortion of testicular architecture, in G4 - enhanced spermatogenesis, in G5 - moderate distortion of the seminiferous tubules, and G6 - enhanced spermatogenesis. A high dose of Mmahi salt is detrimental to sperm parameters and testicular histology. However, this study has shown that date fruit extract can improve sperm parameters and testicular histology in male wistar rats fed with Mmahi salt.

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“…While the hallmark of T2DM is insulin resistance (IR), it is associated with other metabolic disorders such as dyslipidemia and obesity [8]. At the same time, the prevalence of essential arterial hypertension (AH) in diabetic patients is higher 2-3 times than in the general population; whilst 70% of patients with T2DM have elevated blood pressure, which significantly increases the risk of cardiovascular complications, that worsen prognosis and quality of the lives of the patients being one of the main causes of mortality [9][10][11]. It was found that elevation of systolic blood pressure for every 10 mmHg in patients with T2DM increases the risk of development of cardiovascular complications by 20% [12].…”

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confidence: 99%

“…Moreover, hyperuricemia is a well-known independent predictor of CKD development and progression [9]. Thus, the research of Okinawa General Health Maintenance Association, which included 6400 persons with baseline normal renal function, has shown that uricemia at the level of more than 8 mg/dl is associated with increased risk of renal impairment by 2.9 times in males and by 10.0 times in females within two years of observation [29].…”

mentioning

confidence: 99%

Association of serum uric acid with albuminuria in type 2 diabetic patients with comorbid obesity and/or essential arterial hypertension

Marushchak

Krynytska

Lepyavko

2022

Ukr. J. Nephrol. and Dial.

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Abstract. Decompensation of diabetes mellitus type 2 (T2DM), duration of the disease, level of proteinuria, obesity and essential arterial hypertension (AH) play the main role in the development and progress of diabetic nephropathy. The present study aimed to analyze the level of serum uric acid in type 2 diabetic patients with comorbid overweight/obesity and AH and to find its possible correlations with lipid panel data and urinary albumin excretion. Methods. 579 medical records of type 2 diabetic patients treated at the Endocrinological department of the municipal non-profit enterprise "Ternopil University Hospital" of Ternopil Regional Council (Ternopil) in 2018-2019 years were analyzed. Results. The analysis of renal panel data of type 2 diabetic patients with comorbid overweight/obesity and AH found out that only serum levels of urea and uric acid were statistically different in the patients with only T2DM and comorbid course of T2DM. Herewith the maximal changes were established for serum uric acid level, which in type 2 diabetic patients with comorbid obesity exceeded by 175.9 % data of only T2DM patients. Moreover, it was established a significant direct relationship between serum uric acid level and BMI and dyslipidemia in both groups of type 2 diabetic patients - with comorbid obesity and with comorbid obesity and AH. At the same time, a significant direct association between serum uric acid level and albuminuria was established only in type 2 diabetic patients with comorbid obesity and AH. Conclusions. Our retrospective study indicates that serum uric acid level is markedly elevated and positively associated with albuminuria in type 2 diabetic patients with comorbid obesity and AH and can be used as a biomarker allowing further risk stratification for development and/or progress of diabetic nephropathy in this cohort of the patients.

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Features of Asymptomatic Hyperuricemia in Patients With Diabetes Mellitus Type 2 and Concomitant Essential Arterial Hypertension

Cited by 13 publications

References 0 publications

Optimization of Delirium Care in Adult Patients with Cancer: A Comprehensive and Integrative Review of Efficacy and Patient Outcomes

Optimization of Delirium Care in Adult Patients with Cancer: A Comprehensive and Integrative Review of Efficacy and Patient Outcomes

Sperm Parameters and Testicular Histology of Male Wistar Rats Treated with Phoenix Dactylifera after Consumption of Local Mmahi Salt

Association of serum uric acid with albuminuria in type 2 diabetic patients with comorbid obesity and/or essential arterial hypertension

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