2013
DOI: 10.4161/auto.23689
|View full text |Cite
|
Sign up to set email alerts
|

Features of autophagic cell death in Plasmodium liver-stage parasites

Abstract: Analyzing molecular determinants of Plasmodium parasite cell death is a promising approach for exploring new avenues in the fight against malaria. Three major forms of cell death (apoptosis, necrosis and autophagic cell death) have been described in multicellular organisms but which cell death processes exist in protozoa is still a matter of debate. Here we suggest that all three types of cell death occur in Plasmodium liver-stage parasites. Whereas typical molecular markers for apoptosis and necrosis have not… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
2

Citation Types

5
70
1

Year Published

2013
2013
2023
2023

Publication Types

Select...
5
2
1

Relationship

0
8

Authors

Journals

citations
Cited by 67 publications
(78 citation statements)
references
References 56 publications
5
70
1
Order By: Relevance
“…22,23 In this study, we demonstrated the unique molecular features of the protein and present for the first time, the spatial and temporal distribution of ATG8-containing organelles in intrahepatic parasites in both P. falciparum and P. berghei. Our findings highlight the potential of autophagy machinery as an emerging target for malaria therapy.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…22,23 In this study, we demonstrated the unique molecular features of the protein and present for the first time, the spatial and temporal distribution of ATG8-containing organelles in intrahepatic parasites in both P. falciparum and P. berghei. Our findings highlight the potential of autophagy machinery as an emerging target for malaria therapy.…”
Section: Introductionmentioning
confidence: 99%
“…[16][17][18][19][20] Plasmodium parasites contain a limited number of known autophagy-related genes compared with the large repertoire of orthologs in yeast and higher eukaryotes. [10][11][12][21][22][23] It remains an open question whether the malaria parasites have a primitive form of autophagy or if they contain specialized autophagyrelated genes that are absent from yeast and metazoan genomes. Among Atg proteins, the genome of Plasmodium falciparum and Plasmodium berghei encodes orthologs of the 4 components of the ATG8-conjugation pathway (ATG4, ATG3, ATG7, and ATG8).…”
Section: Introductionmentioning
confidence: 99%
“…This basal level of autophagy occurring throughout parasite development might be involved in remodeling of subcellular organelles during intra-erythrocytic growth, and such a role has also been proposed for microneme clearance following sporozoite invasion of hepatocytes 32 although a recent paper concludes that autophagy does not occur in liver stages of the parasite. 33 A higher level of autophagy is induced upon amino acid deprivation, with many larger structures including the food vacuole becoming labeled with both PfATG8 and PfRAB7. It appears that amino acid starvation does not result in an increased transcription of ATG8 and RAB7, 17 which is consistent with our finding that the parasites respond rapidly to amino acid starvation by generating increased numbers of autophagosomes.…”
mentioning
confidence: 99%
“…All the three forms of cell death: apoptosis (type I), autophagy (type II) and necrosis (type III) have been suggested to occur in P. falciparum [22]. However, if only we can identify and understand the molecular mechanisms behind these cell death pathways, it may be possible to trigger them to eliminate the parasite.…”
Section: Autophagy In Plasmodiummentioning
confidence: 99%
“…In case of organelle expulsion, it is known that during the morphological transformation of Plasmodium in the early liver stages, certain organelles used for liver cell invasion (rhoptries, micronemes and others) get expelled from parasite. The presence of double-membraned structures, morphologically similar to autophagosomes containing micronemes, indicates that exophagy might be important for parasite differentiation in liver stages [22]. Atg8 is an autophagy marker protein which remains attached with the pre-autophagosome and autophagosome during lysosomal fusion.…”
Section: Autophagy In Plasmodiummentioning
confidence: 99%