Features of borderline personality disorder as a mediator of the relation between childhood traumatic experiences and psychosis-like experiences in patients with mood disorder

Baryshnikov, Ilya; Aaltonen, Kari; Suvisaari, Jaana; Koivisto, Maaria; Heikkinen, Martti; Joffe, Grigori; Isometsä, Erkki

doi:10.1016/j.eurpsy.2017.12.005

Cited by 5 publications

(4 citation statements)

References 84 publications

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“…In particular, we were interested in the mechanisms of the well-established relationship between exposure to childhood trauma and PLEs among non-psychotic adolescents seeking for psychiatric care. Based on the existing literature [39, 54–56] we hypothesized that borderline personality features may mediate the relationship. In addition, we considered also mediating role of other psychopathological symptoms – depression and anxiety.…”

Section: Discussionmentioning

confidence: 99%

The mediating role of borderline personality features in the relationship between childhood trauma and psychotic-like experiences in a sample of help-seeking non-psychotic adolescents and young adults

et al. 2018

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Objective:Psychotic-like experiences (PLEs) often occur across different non-psychotic disorders in adolescent and young adult population and are related to early trauma. However, the mechanisms of how exposure to early trauma shapes the risk of PLEs are unclear. In our study, we investigated whether borderline personality features and further non-psychotic symptoms, i.e. factors related to both PLEs and childhood trauma, may mediate the relationship between childhood trauma and PLEs.Methods:Two hundred inpatients aged 16–21 years who were treated due to non-psychotic disorders were included. PLEs were assessed with the Prodromal Questionnaire (PQ-16). Childhood Trauma was assessed with the Adverse Childhood Experience Questionnaire (ACE). Borderline personality features were assessed by using the Borderline-Symptom Checklist (BSL-23). Presence and frequency of depressive symptoms and anxiety were assessed by Patient Health Questionnaire (PHQ-9) and Generalized Anxiety Disorder Questionnaire (GAD-7).Table 1Clinical characteristics (n = 200).Mean (SD)Male/female67/133Age18.72 (1.85)Clinical diagnosisDepressive disorder (F32.1, F32.2, F33.0, F33.1, F33.2)167 (83.5%)Anxiety disorder (F40.1, F41.0, F41.1, F41.2)51 (25.5%)ComorbiditiesPTSD26 (13.0%)Personality disorders (F60.30, F60.31, F60.4, F60.6, F60.7, F60.8, F61)124 (66.5%)Eating disorder (F50.0, F50.1, F50.2)19 (9.5%)Others (F42.1, F42.2, F45.1, F44.5, F90.0)33 (16.5%)Measures: The Structured Clinical Interview for the Diagnostic and statistical manual of mental disorders, 4th edition (DSM-IV) (SCID-I) and the Structured Clinical Interview for DSM-IV Axis II Personality Disorders II (SCID-II) were used to identify the clinical diagnoses.Results:A significant relationship between childhood trauma (ACE total score) and PLEs was found (ß = 0.30, 95% CI 0.247--0.659). In particular, emotional neglect (r = 0.298, p < 0.001) and sexual abuse (r = 0.264, p < 0.001) were significantly associated with PLEs. Borderline personality features fully mediated the relationship of childhood trauma and PLEs (ß = 0.12, 95% CI: -0.019--0.370). Anxiety and Depression showed a significant, but partial mediation of the relationship.Conclusion:Borderline personality features seem to be an important mediator of the relationship between childhood trauma and PLEs in adolescent patients with different non-psychotic psychiatric disorders. Theoretical and clinical implications are discussed.

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Section: Discussionmentioning

confidence: 99%

The mediating role of borderline personality features in the relationship between childhood trauma and psychotic-like experiences in a sample of help-seeking non-psychotic adolescents and young adults

et al. 2018

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“…Not only are personality pathologies associated with mental illness, but childhood traumatic experiences (CTE) are also closely related to it 11 . More crucial is that the relationship between CTE and PD is extremely close, possibly together, they affected subsequent psychiatric disorders 12,13 . However, PD classifications remain remarkably heterogeneous and are often associated with multiple forms of childhood traumatic experiences (CTE) 14 .…”

Section: Introductionmentioning

confidence: 99%

“…However, PD classifications remain remarkably heterogeneous and are often associated with multiple forms of childhood traumatic experiences (CTE) 14 . Previous studies 12,13 have tended to focus on the correlational pattern between PD and CTE, but have not yet tended to use these correlation characteristics to construct subtypes of mental disorders or subgroups of psychiatric patients. The present study applied, for the first time, a canonical correlation analysis (CCA) method for defining subtypes by clustering psychiatric patients, with different clinical diagnoses, according to the patterns of the relationship (canonical variates) between PD traits and CTE.…”

Section: Introductionmentioning

confidence: 99%

Transdiagnostic Dimensions towards Personality Pathology and Childhood Traumatic Experience in a Clinical Sample: Subtype Classification by a Cross-sectional Analysis

Wang

Sun

Tang

et al. 2019

Sci Rep

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Psychiatric disorders are highly heterogeneous syndromes often explained by underlying and internalized personality disorder(PD) traits that are affected by externalized childhood trauma experiences(CTE). The present study investigated the differential subtype model by examining the association between PD traits and CTE in a clinical sample with transdiagnostic psychopathology. Outpatients(n = 2090) presenting for psychiatric treatment completed self-reported measures of PD traits(Personality Diagnostic Questionnaire) and the childhood adversity(Child Trauma Questionnaire). Canonical variates were generated by canonical correlation analysis(CCA) and then used for hierarchical cluster analysis to produce subtypes. A support vector machine(SVM) model was used and validated using a linear kernel to assess the utility of the extracted subtypes of outpatients in clinical diagnosis classifications. The CCA determined two linear combinations: emotional abuse related dissociality PD traits(antisocial and paranoid PD) and emotional neglect related sociality PD traits(schizoid, passive-aggressive, depressive, histrionic, and avoidant PD). A cluster analysis revealed three subtypes defined by distinct and relatively homogeneous patterns along two dimensions, and comprising 17.5%(cluster-1, n = 365), 34.8%(cluster-2, n = 727), and 47.8%(cluster-3, n = 998) of the sample, each with distinctive features of PD traits and CTE. These subtypes suggest more distinct PD trait correlates of CTE manifestations than were captured by clinical phenomenological diagnostic definitions. Our results highlight important subtypes of psychiatric patients that highlight PD traits and CTE that transcend current diagnostic boundaries. The three different subtypes reflect significant differences in PD and CTE characteristics and lend support to efforts to develop PD and childhood trauma targeted psychotherapy that extends to clinical diagnosis-based interventions.

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“…Некоторые зарубежные авторы [26,27], рассматривая вопросы этиопатогенеза пограничных расстройств личности, уделяют внимание изменением настроения у пациентов. Считается, что психические травмы у пациентов с пограничными расстройствами личности являются факторами риска для психических расстройств.…”

Section: особенности формирования пограничных состояний психической дunclassified

The role of typology and reactivity in initiation and development of disadaptive disorders

Артеменков¹

2019

Nauchno-Prakticheskii Zhurnal «Patogenez»

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В данном обзоре поднимается проблема переходных состояний, возникающих на грани нормы и патологии, которые принято называть пограничными психическими расстройствами (ППР). В работе высказана гипотеза о том, что в современных условиях жизни человека часто возникает дезинтеграция психической деятельности в связи со значительной информационной нагрузкой на интегративные системы головного мозга. В обобщении материала сделан акцент на описание внутренних (биологических) факторов, определяющих возникновение и развитие дезадаптивных состояний и сопровождающих их пограничных психических расстройств. Обсуждается вопрос о роли индивидуально-типологических свойств нервной системы и реактивности личности в формировании и развитии пограничной психической патологии. Рассматривается вопрос о лечебно-профилактических и коррекционных мероприятиях, направленных на снижение дезадаптивных проявлений у человека в процессе жизнедеятельности и минимизацию пограничных психических расстройств. This review focuses on the issue of transition states that occur on the edge of normal and pathological conditions and are called borderline mental disorders (BMD). The author hypothesized that in the modern life, disintegration of mental activity frequently develops in association with a significant informational load on brain integrative systems. In summarizing the material, an emphasis was made on description of internal (biological) factors that determine the emergence and development of disadaptive conditions and concurrent BMDs. The review discusses the role of individual typological features of the nervous system and individual reactivity in the formation and development of BMD and focuses on therapeutic, preventive, and correctional measures aimed at alleviating disadaptive signs in humans and minimizing BMDs.

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Features of borderline personality disorder as a mediator of the relation between childhood traumatic experiences and psychosis-like experiences in patients with mood disorder

Abstract: Self-reported cognitive-perceptual symptoms of BPD fully mediate, while affective, behavioural and interpersonal symptoms only partially mediate the relationships between CEs and PEs. Recognition of co-morbid features of BPD in patients with mood disorders reporting PEs is essential.

Cited by 5 publications

References 84 publications

The mediating role of borderline personality features in the relationship between childhood trauma and psychotic-like experiences in a sample of help-seeking non-psychotic adolescents and young adults

The mediating role of borderline personality features in the relationship between childhood trauma and psychotic-like experiences in a sample of help-seeking non-psychotic adolescents and young adults

Transdiagnostic Dimensions towards Personality Pathology and Childhood Traumatic Experience in a Clinical Sample: Subtype Classification by a Cross-sectional Analysis

The role of typology and reactivity in initiation and development of disadaptive disorders

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