Features of cancer in teenagers and young adults in primary care: a population-based nested case–control study

Dommett, Rachel; Redaniel, Maria Theresa; Stevens, Michaël C.G.; Hamilton, William; Martin, Richard M.

doi:10.1038/bjc.2013.191

Cited by 47 publications

(40 citation statements)

References 13 publications

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“…6,15,16 Abdominal pain, fatigue, stomach/bowel problems, infection, back pain, and pain on drinking alcohol have also been reported. 6,17 This study aimed to identify and quantify…”

Section: Introductionmentioning

confidence: 99%

Quantifying the risk of non-Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a large case–control study using electronic records

et al. 2015

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“…6,15,16 Abdominal pain, fatigue, stomach/bowel problems, infection, back pain, and pain on drinking alcohol have also been reported. 6,17 This study aimed to identify and quantify…”

Section: Introductionmentioning

confidence: 99%

Quantifying the risk of non-Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a large case–control study using electronic records

et al. 2015

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“…An overall malignant probability of 0·5% for lymphadeno pathy in someone aged 16-24 years is almost certainly much higher if the person has particular features suggesting a cancer diagnosis (eg, hard consistency and large size of masses, accompanying symptoms of fever, weight loss, or night sweats). 112 Similarly, fatigue, pallor, and bruising have very low absolute risks but, when supplemented by repeated consultations or parental anxiety, probably carry suffi ciently high risks to warrant blood tests.…”

mentioning

confidence: 99%

The expanding role of primary care in cancer control

Rubin

Berendsen

Crawford

et al. 2015

The Lancet Oncology

448

450

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The nature of cancer control is changing, with an increasing emphasis, fuelled by public and political demand, on prevention, early diagnosis, and patient experience during and after treatment. At the same time, primary care is increasingly promoted, by governments and health funders worldwide, as the preferred setting for most health care for reasons of increasing need, to stabilise health-care costs, and to accommodate patient preference for care close to home. It is timely, then, to consider how this expanding role for primary care can work for cancer control, which has long been dominated by highly technical interventions centred on treatment, and in which the contribution of primary care has been largely perceived as marginal. In this Commission, expert opinion from primary care and public health professionals with academic and clinical cancer expertise-from epidemiologists, psychologists, policy makers, and cancer specialists-has contributed to a detailed consideration of the evidence for cancer control provided in primary care and community care settings. Ranging from primary prevention to end-of-life care, the scope for new models of care is explored, and the actions needed to eff ect change are outlined. The strengths of primary care-its continuous, coordinated, and comprehensive care for individuals and families-are particularly evident in prevention and diagnosis, in shared follow-up and survivorship care, and in end-of-life care. A strong theme of integration of care runs throughout, and its elements (clinical, vertical, and functional) and the tools needed for integrated working are described in detail. All of this change, as it evolves, will need to be underpinned by new research and by continuing and shared multiprofessional development.

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“…Health services research should feature as a significant part in investigating and improving known differences in the TYA population such as delays to diagnosis [44] and participation in clinical trials to explain our findings, and improve survival.…”

Section: Discussionmentioning

confidence: 96%

Survival patterns in teenagers and young adults with cancer in the United Kingdom: Comparisons with younger and older age groups

Stark

Bowen

Dunwoodie

et al. 2015

European Journal of Cancer

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Aims: We aimed to describe and compare survival in teenagers and young adults (TYAs) with cancer to that of younger children and older adults, to identify sub-populations at greater or lesser risk of death. Methods: We compared survival in cancer patients diagnosed in the United Kingdom aged 13-24 years (TYAs) to those aged 0-12 (children) and 25-49 years (adults) using the National Cancer In pattern 1, the younger the age-group the better the 1-and 5-year survival (acute lymphoid leukaemia, carcinoma of ovary and melanoma). In pattern 2, TYAs had a worse 5-year survival than both children and young adults (bone and soft tissues sarcomas). In pattern 3, TYAs had a worse 1-year survival but no difference at 5-years (carcinoma of cervix and female breast). In pattern 4, TYAs had better 1-year survival than adults, but no difference at 5 years (carcinoma of liver and intrahepatic bile ducts, germ cell tumours of extra-gonadal sites). In pattern 5, the younger the age-group the better the 5-year survival, but the difference developed after 1-year (acute myeloid leukaemia, carcinoma of colon and rectum). In pattern 6, there was no difference in 1-and 5-year survival between TYAs and adults (testicular germ cell tumours, ovarian germ cell tumours and carcinoma of thyroid). Conclusion: TYAs with specific cancer diagnoses can be grouped according to 1-and 5-year survival patterns compared to children and young adults. To further improve survival for TYAs, age-specific biology, pharmacology, proteomics, genomics, clinician and patient behaviour studies embedded within clinical trials are required.3

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Features of cancer in teenagers and young adults in primary care: a population-based nested case–control study

Cited by 47 publications

References 13 publications

Quantifying the risk of non-Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a large case–control study using electronic records

Quantifying the risk of non-Hodgkin lymphoma in symptomatic primary care patients aged ≥40 years: a large case–control study using electronic records

The expanding role of primary care in cancer control

Survival patterns in teenagers and young adults with cancer in the United Kingdom: Comparisons with younger and older age groups

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