Features of Clinical Manifestations, Free Radical, Coagulation and Aggregation Properties of Blood in Patients With Craniocerebral Trauma

Abstract

Introduction: In recent years in Ukraine, as in the entire world, there has been an increase in cases of domestic injuries with a raise in the number of patients with craniocerebral trauma and its consequences. The aim of our research was to study clinical symptoms, the state of free radical oxidation, aggregate and hemocoagulative properties of blood in patients with mild craniocerebral trauma. Materials and methods: We conducted comprehensive clinical and laboratory examination of 34 patients with mild craniocerebral trauma and 20 apparently healthy patients (the control group). The diagnosis was made under ICD-10. The verification of the diagnosis was based on data from clinical examination, neurological status of neuroimaging (computer tomography and magnetic resonance imaging). The study group included 24 men and 10 women aged from 19 to 40. In addition, 20 apparently healthy individuals of the same age were examined, who comprised the control group (14 men and 6 women). In the blood parameters of all patients, we examined free radical oxidation, hemostasis and aggregation properties of platelets. Results: The conducted study revealed clinical disturbances, changes in the parameters of free radical lipid oxidation, coagulation and microcirculatory hemostasis. Conclusions: All patients with mild craniocerebral trauma, develop disturbances in the form of symptoms of microorganic lesion of the central nervous system: convergence weakness in 100% of patients, Mann’s symptom (76.4%), disruption of the function of the cranial nerves (58.8%), signs of pyramidal insufficiency (68.4%), vestibular disorders (94.1%), autonomic vascular dysfunction (100%). Mild craniocerebral trauma is accompanied by the activation of free radical lipid oxidation processes, decreased activity of antioxidant enzymes, hypercoagulation, and increased aggregation properties of platelets.

[Retracted] Investigation of the Effects of Large Bone Flap Craniotomy on Cerebral Hemodynamics, Intracranial Infection Rate, and Nerve Function in Patients with Severe Craniocerebral Trauma

“…The injury of patients with craniocerebral trauma is related to hematoma, and the intracranial pressure can lead to the patient's disturbance of consciousness or coma [ 6 ]. The common complications of severe craniocerebral injury mainly refer to the complications of other parts except the craniocerebral injury itself.…”

Curative Effect of Early Full Nursing Combined with Postdischarge Continuation Nursing on Patients after Craniocerebral Trauma

“…Craniocerebral trauma is one of the common emergency departments of brain surgery, and its clinical symptoms are head trauma, hemorrhage, intracranial hypertension and disturbance of consciousness caused by trauma [ 1 , 2 ]. The brain tissue damage of the patient causes the nervous system function to be affected, which affects the cognitive ability, motor function, and inconvenience to daily life [ 3 , 4 ]. Early full nursing for some patients with dysfunction is helpful to accelerate the reorganization of central nervous system function and coordinate muscle and limb activities [ 5 , 6 ].…”

Dynamics of Anti-Antioxidant System Indicators in the Postoperative Period in Patients With Periodontitis Accompanied by Different Reactivaty of the Organism

“…In the clinic, it has been found out that in periodontitis in the blood of patients there is an accumulation of LPO products due to a significant increase in the level of malonic dialdehyde with a decrease in the concentration of superoxide dismutase and catalase [6,7]. The results of the study of total antioxidant activity showed that the values of this parameter in the tissues of the gums in cases of intact periodontitis and generalized periodontitis have significant differences [8,9].…”