The sense of body ownership has been studied using rubber hand illusion (RHI) and full-body illusion (FBI). It has recently become clear that consciously interpreting a fake body as one’s own, in a top-down manner, also influences these body illusions. Furthermore, a study interestingly found that the influence of top-down interpretation is moderated by the degree of depersonalization, which is a symptom of a lack of sense of body ownership. In a case study of depersonalization, it has been suggested that a top-down interpretation of one’s own body as a negative physical state makes it difficult to feel a sense of body ownership, but this has not been examined. In the present study, we examined the influence of negative top-down interpretation using an FBI procedure in which a fake body was instructed to be viewed as a negative self-body (“View the virtual body’s back while regarding the virtual body as your own experiencing abdominal pain”). We used skin conductance responses to the fear stimulus presented after the visual-tactile stimuli presentation as the degree of FBI. The results indicated that no difference in skin conductance response was observed between the synchronous and asynchronous presentation of visual-tactile stimuli when the participants were instructed to interpret the virtual body as their own in a negative physical state (Z = -0.877, p = 0.381), and the degree of FBI was smaller than when the participants were instructed to interpret the virtual body top-down as a neutral self-body (Z = 2.159, p = 0.031). This study’s finding that the FBI was inhibited by manipulation of the top-down interpretation suggested that top-down interpretation can be a factor that inhibits the creation of a sense of body ownership.