Features of electron beam deposition of polymer coatings with the prolonged release of the drug component

Li, Beibei; Liu, Yiming; Rogachev, A.V.; Yarmolenko, V.A.; Рогачев, А.А.; Pyzh, A.E.; Jiang, Xiaohong; Yarmolenko, М.А.

doi:10.1016/j.msec.2020.110730

Cited by 12 publications

(4 citation statements)

References 37 publications

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“…The average distance from the electron gun to the target was 150 mm, and from the target to the sample was 200 mm. 38 In the "wet chemistry" method, samples of nonwoven materials with a size of 100 Â 100 mm were placed in a Schott filter, treated with an appropriate water-alcohol solution of ZnO, d < 100 nm (Sigma Aldrich) or OCT.…”

Section: Methodsmentioning

confidence: 99%

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Modification of nonwoven polymer materials for increasing of their filtration and antibacterial properties

Avdeeva,

Petkevich,

Mikhalko

et al. 2023

Polymer Engineering & Sci

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Polytetrafluoroethylene (PTFE), octenidine dihydrochloride (OCT), and zinc oxide (ZnO) were used to modify the polypropylene nonwoven material by the methods of “wet chemistry” and low‐energy electron beam deposition (EBD). The influence of nonwoven material modification on the morphology, chemical composition, filtration, and antibacterial properties was established. The modified material has antibacterial activity against the gram‐positive strain Staphylococcus aureus and against gram‐negative strains of Escherichia coli and Klebsiella pneumoniae (suppression of bacterial growth for materials with OCT was 100%, with ZnO—70%). PTFE application to Aquaspun leads to a significant increase in the contact angle (from 141.3° to 152.7°) and air filtration efficiency (from 78.3% to 83.4%), which provides the barrier properties of the material. It was established that the material obtained using low‐energy EBD demonstrated a more pronounced antimicrobial potential against the tested strains of St. aureus.Highlights The influence of polypropylene nonwoven materials surface modification methods is systematically investigated. Low‐energy electron beam deposition increases antibacterial and filtration properties of nonwoven materials. Surface modification methods increase barrier properties of polypropylene nonwoven materials.

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Section: Methodsmentioning

confidence: 99%

“…Coating was carried out at an initial pressure of residual gases in a vacuum chamber of ≈4 × 10 −3 Pa. The average distance from the electron gun to the target was 150 mm, and from the target to the sample was 200 mm 38 …”

Section: Methodsmentioning

confidence: 99%

Modification of nonwoven polymer materials for increasing of their filtration and antibacterial properties

Avdeeva,

Petkevich,

Mikhalko

et al. 2023

Polymer Engineering & Sci

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“…Besides, the height of the peak (C-O, C-N) decreases from 11263 to 7567 (average of double-layer films of different PU contents). It indicates there is a decrease in the content of nitrogen atoms as a result of an intense degradation process of both components which interact with each other tightly in the influence zone of the electron beam [22].…”

Section: Tablementioning

confidence: 99%

PCL Based CIP-Loaded Double-Layer Films Deposited by Low-Electron Beam Dispersion Method and its Antibacterial Properties

Zhou

et al. 2020

Eurasian Chem. Tech. J.

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In this paper, low-electron beam dispersion (EBD) method is used to prepare a kind of double-layer films on different substrates. The bottom layer is a mechanically stirred mixture of the degradable polycaprolactone (PCL) and ciprofloxacin (CIP), and the top layer is polyurethane (PU) film. The molecular structure, chemical composition and morphology of the double-layer films were investigated by FTIR, XPS and SEM. The results showed that the surfaces of the double-layer films are uniform and the thicknesses can reach micron level. In addition, the two layers are well bonded. Then the films were sliced and immersed in PBS solution, and the time-dependent variable was used to analyze the kinetic slow-release behavior of CIP in the double-layer films by agar diffusion antibacterial experiments. It can be seen that sustained release time of CIP in the double-layer films can be up to 7 days, which is due to fact that the upper PU film working as a sealing layer helps to realize the drug slow-release. Based on the above research, the comprehensive performance of the films with the composition of PCL:CIP/PU=1:1/1 is the best.

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“…One of the most successful approaches is by coating the surface with one (or more) molecules with recognized antimicrobial properties since this assures increased sterility of the material while preserving its bulk characteristics [11][12][13][14]. Polymeric coatings emerge in this context as particularly interesting considering the ability of polymers to form multivalent interactions to promote loading and, in some cases, also to allow the controlled release of drugs, including antifungals [6,15]. Although promising, two important obstacles to this approach are still recognized.…”

Section: Introductionmentioning

confidence: 99%

Bioactive Coatings with Ag-Camphorimine Complexes to Prevent Surface Colonization by the Pathogenic Yeast Candida albicans

et al. 2021

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Currently there is a gap between the rate of new antifungal development and the emergence of resistance among Candida clinical strains, particularly threatened by the extreme adhesiveness of C. albicans to indwelling medical devices. Two silver camphorimine complexes, [Ag(OH){OC10H14N(C6H4)2NC10H14O}] (compound P) and [{Ag(OC10H14NC6H4CH3-p)}2(μ-O)] (compound Q), are herein demonstrated as having high inhibiting activity towards the growth of Candida albicans and Candida glabrata clinical strains resistant to azoles, the frontline antifungals used in clinical practice. Compounds P and Q were also explored as bioactive coatings to prevent colonization by C. albicans and colonize the surface of indwelling medical devices, resulting in persistent infections. Functionalization of stainless steel with polycaprolactone (PCL) matrix embedded with compounds P or Q was reported for the first time to inhibit the colonization of C. albicans by 82% and 75%, respectively. The coating of PCL loaded with Q or P did not cause cytotoxic effects in mammalian cells, demonstrating the biocompatibility of the explored approach. The identification and further exploration of new approaches for surface engineering based on new molecules that can sensitize resistant strains, as herein demonstrated for complexes P and Q, is a significant step forward to improve the successful treatment of candidiasis.

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Features of electron beam deposition of polymer coatings with the prolonged release of the drug component

Cited by 12 publications

References 37 publications

Modification of nonwoven polymer materials for increasing of their filtration and antibacterial properties

Modification of nonwoven polymer materials for increasing of their filtration and antibacterial properties

PCL Based CIP-Loaded Double-Layer Films Deposited by Low-Electron Beam Dispersion Method and its Antibacterial Properties

Bioactive Coatings with Ag-Camphorimine Complexes to Prevent Surface Colonization by the Pathogenic Yeast Candida albicans

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